{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:38:21Z","timestamp":1790257101666,"version":"4.1.0"},"reference-count":25,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T00:00:00Z","timestamp":1714780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Women with polycystic ovary syndrome (PCOS), which is the most common endocrine disorder in women of reproductive age, have a potentially increased risk of gestational diabetes mellitus (GDM).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To examine the impact of PCOS on GDM based on maternal body mass index (BMI) using data from a large birth cohort study in Japan.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Prospective observational study using data from the Japan Environment and Children's Study (JECS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>Singleton pregnancies in the JECS during 2011-2014 were included. Mothers with HbA1c levels of \u22656.5% in the first trimester and history of diabetes mellitus or steroid use during pregnancy were excluded.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures<\/jats:title>\n                  <jats:p>Participants were categorized according to their prepregnancy BMIs: G1 (&amp;lt;18.5 kg\/m2), G2 (18.5-19.99 kg\/m2), G3 (20.0-22.99 kg\/m2), G4 (23.0-24.99 kg\/m2), and G5 (\u226525.0 kg\/m2). The impact of PCOS on early(Ed) and late-onset(Ld) GDM for each group was estimated using a multiple logistic regression model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We included 92 774 participants, comprising 2012 PCOS(+) cases. GDM occurrence was higher in women with PCOS (P &amp;lt; .001). PCOS had no effect on GDM in G1, G2, and G3. In G4, PCOS increased the risk of Ed GDM (adjusted odds ratio [aOR]: 3.27; 95% confidence interval [CI], 1.29-8.29). In G5, PCOS increased the risk of both Ed (aOR: 2.48; 95% CI, 1.53-4.02) and Ld GDM (aOR: 1.94; 95% CI, 1.23-3.07).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The impact of PCOS on GDM occurrence depended on the prepregnancy BMIs, which may facilitate personalized preconception counseling among women with PCOS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgae293","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T04:47:08Z","timestamp":1714711628000},"page":"e1167-e1172","source":"Crossref","is-referenced-by-count":3,"title":["Risk of Gestational Diabetes in Women With PCOS Based on Body Mass Index: The Japan Environment and Children's Study"],"prefix":"10.1210","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7538-1084","authenticated-orcid":false,"given":"Chihiro","family":"Okoshi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine , Fukushima 960-1295 ,","place":["Japan"]},{"name":"Fukushima Regional Center for the Japan Environmental and Children's Study , Fukushima 960-1295 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo","family":"Kyozuka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine , Fukushima 960-1295 ,","place":["Japan"]},{"name":"Fukushima Regional Center for the Japan Environmental and Children's Study , Fukushima 960-1295 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toma","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine , Fukushima 960-1295 ,","place":["Japan"]},{"name":"Fukushima Regional Center for the Japan Environmental and Children's Study , Fukushima 960-1295 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine , Fukushima 960-1295 ,","place":["Japan"]},{"name":"Fukushima Regional Center for the Japan Environmental and Children's Study , Fukushima 960-1295 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Murata","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environmental and Children's Study , Fukushima 960-1295 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Isogami","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine , Fukushima 960-1295 ,","place":["Japan"]},{"name":"Fukushima Regional Center for the Japan Environmental and Children's Study , Fukushima 960-1295 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Sato","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environmental and Children's Study , Fukushima 960-1295 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Ogata","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environmental and Children's Study , Fukushima 960-1295 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuaki","family":"Hosoya","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environmental and Children's Study , Fukushima 960-1295 ,","place":["Japan"]},{"name":"Department of Pediatrics, Fukushima Medical University School of Medicine , Fukushima 960-1295 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4715-2840","authenticated-orcid":false,"given":"Seiji","family":"Yasumura","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environmental and Children's Study , Fukushima 960-1295 ,","place":["Japan"]},{"name":"Department of Public Health, Fukushima Medical University School of Medicine , Fukushima 960-1295 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environmental and Children's Study , Fukushima 960-1295 ,","place":["Japan"]},{"name":"Department of Pediatrics, Fukushima Medical University School of Medicine , Fukushima 960-1295 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekazu","family":"Nishigori","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environmental and Children's Study , Fukushima 960-1295 ,","place":["Japan"]},{"name":"Fukushima Medical Center for Children and Women, Fukushima Medical University , Fukushima 960-1295 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michihiro","family":"Kamijima","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Nagoya City University Graduate School of Medical Sciences , Nagoya 467-8601 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"National Institute for Environmental Studies, Programme Office of the Japan Environment and Children's Study , Tsukuba 305-8506 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiro","family":"Ohya","sequence":"additional","affiliation":[{"name":"Allergy Center, National Center for Child Health and Development , Tokyo 157-0074 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiko","family":"Kishi","sequence":"additional","affiliation":[{"name":"Center for Environmental and Health Sciences, Hokkaido University , Sapporo 060-0812 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