{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T22:29:56Z","timestamp":1785018596574,"version":"3.55.0"},"reference-count":57,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171692"],"award-info":[{"award-number":["82171692"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2022JQ33"],"award-info":[{"award-number":["ZR2022JQ33"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["2021-I2M-5-001"],"award-info":[{"award-number":["2021-I2M-5-001"]}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2700604"],"award-info":[{"award-number":["2021YFC2700604"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Special Support Program for High-level Talents"},{"name":"Taishan Scholars Program for Young Experts of Shandong Province","award":["tsqn201909195"],"award-info":[{"award-number":["tsqn201909195"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Embryo biopsy, which is necessary for preimplantation genetic testing (PGT), has not been fully investigated regarding its potential influences and safety. Previous studies of children born from biopsied embryos (PGT children) have primarily centered around their growth and neuropsychological development, while there remains limited knowledge concerning their endocrine and metabolic parameters.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This study aims to examine the effect of trophectoderm (TE) biopsy on metabolic outcomes for PGT children.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 1267 children from the Center for Reproductive Medicine, Shandong University, who were conceived through in vitro fertilization (IVF)\/intracytoplasmic sperm injection (ICSI) with and without PGT, were analyzed in this study. Three sets of measurements pertaining to growth and metabolism were taken at each predetermined follow-up time point. The linear regression models within a generalized estimating equation were employed to examine the associations between the PGT and each outcome measure and the approach of false discovery rate was used to correct for multiple comparisons.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>After controlling for confounding factors and correcting for multiple comparisons, no statistically significant difference was identified in any of the measured variables between the PGT children and children conceived by IVF alone (IVF children) and children conceived through IVF using ICSI (ICSI children). The same is true also for age- or sex-based subgroup analyses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Between the ages of 1 and 5 years, there are no clinically adverse metabolic outcomes observed in PGT children, and their metabolic profiles are essentially identical to those of IVF children and ICSI children.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgae315","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T19:34:54Z","timestamp":1716924894000},"page":"e980-e991","source":"Crossref","is-referenced-by-count":2,"title":["Metabolic Profiles of Offspring Born From Biopsied Embryos from Toddlerhood to Preschool Age"],"prefix":"10.1210","volume":"110","author":[{"given":"Jialin","family":"Zhao","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University , Jinan, Shandong 250012 ,","place":["China"]},{"name":"Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No.2021RU001) , Jinan, Shandong 250012 ,","place":["China"]},{"name":"Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University , Jinan, Shandong 250012 ,","place":["China"]},{"name":"Shandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University , Jinan, Shandong 250012 ,","place":["China"]},{"name":"Shandong Provincial Clinical Research Center for Reproductive Health , Shandong University, Jinan, Shandong 250012 ,","place":["China"]},{"name":"Shandong Technology Innovation Center for Reproductive Health , Shandong University, Jinan, Shandong 250012 ,","place":["China"]},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University , Jinan, Shandong 250012 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6530-8204","authenticated-orcid":false,"given":"Shuo","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University , Jinan, Shandong 250012 ,","place":["China"]},{"name":"Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No.2021RU001) , Jinan, Shandong 250012 ,","place":["China"]},{"name":"Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University , Jinan, Shandong 250012 ,","place":["China"]},{"name":"Shandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University , Jinan, Shandong 250012 ,","place":["China"]},{"name":"Shandong Provincial Clinical Research Center for Reproductive Health , Shandong University, Jinan, Shandong 250012 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Shandong University , Jinan, Shandong 250012 ,","place":["China"]},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics , Shanghai Jiao Tong University, Shanghai 200135 ,","place":["China"]},{"name":"Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai 200135 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2024,5,28]]},"reference":[{"key":"2025031717040215800_dgae315-B1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.rbms.2022.01.001","article-title":"Families formed through assisted reproductive technology: causes, experiences, and consequences in an international context","volume":"14","author":"Kuhnt","year":"2022","journal-title":"Reprod Biomed Soc 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