{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:13:51Z","timestamp":1790874831474,"version":"4.1.0"},"reference-count":79,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK112262"],"award-info":[{"award-number":["R01DK112262"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK131529"],"award-info":[{"award-number":["R01DK131529"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL145372"],"award-info":[{"award-number":["R01HL145372"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23HL156759"],"award-info":[{"award-number":["K23HL156759"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23DK135414"],"award-info":[{"award-number":["K23DK135414"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["UL1RR024975"],"award-info":[{"award-number":["UL1RR024975"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["KL2TR002245"],"award-info":[{"award-number":["KL2TR002245"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tennessee Center for AIDS Research","award":["P30AI110527"],"award-info":[{"award-number":["P30AI110527"]}]},{"DOI":"10.13039\/100000862","name":"Doris Duke Charitable Foundation","doi-asserted-by":"publisher","award":["2021193"],"award-info":[{"award-number":["2021193"]}],"id":[{"id":"10.13039\/100000862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","award":["1021480"],"award-info":[{"award-number":["1021480"]}],"id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Cardiometabolic diseases are common in persons with HIV (PWH) on antiretroviral therapy (ART), which has been attributed to preferential lipid storage in visceral adipose tissue (VAT) compared with subcutaneous adipose tissue (SAT). However, the relationship of SAT-specific cellular and molecular programs with VAT volume is poorly understood in PWH.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We characterized SAT cell-type specific composition and transcriptional programs that are associated with greater VAT volume in PWH on contemporary ART.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We enrolled PWH on long-term ART with a spectrum of metabolic health. Ninety-two participants underwent SAT biopsy for bulk RNA sequencing and 43 had single-cell RNA sequencing. Computed tomography quantified VAT volume and insulin resistance was calculated using the Homeostasis Model Assessment 2 Insulin Resistance (HOMA2-IR).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>VAT volume was associated with HOMA2-IR (P &amp;lt; .001). Higher proportions of SAT intermediate macrophages (IMs), myofibroblasts, and MYOC+ fibroblasts were associated with greater VAT volume using partial Spearman's correlation adjusting for age, sex, and body mass index (r = 0.34-0.49, P &amp;lt; .05 for all). Whole SAT transcriptomics showed PWH with greater VAT volume have increased expression of extracellular matrix (ECM)\u2013 and inflammation-associated genes, and reduced expression of lipolysis- and fatty acid metabolism\u2013associated genes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In PWH, greater VAT volume is associated with a higher proportion of SAT IMs and fibroblasts, and a SAT ECM and inflammatory transcriptome, which is similar to findings in HIV-negative persons with obesity. These data identify SAT cell-type specific changes associated with VAT volume in PWH that could underlie the high rates of cardiometabolic diseases in PWH, though additional longitudinal studies are needed to define directionality and mechanisms.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgae369","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:43:01Z","timestamp":1717116181000},"page":"238-253","source":"Crossref","is-referenced-by-count":11,"title":["Single-Cell Analysis of Subcutaneous Fat Reveals Profibrotic Cells That Correlate With Visceral Adiposity in HIV"],"prefix":"10.1210","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4990-1013","authenticated-orcid":false,"given":"Samuel S","family":"Bailin","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis L","family":"Gabriel","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition , Nashville, Vanderbilt University Medical Center, TN 37232 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rama D","family":"Gangula","sequence":"additional","affiliation":[{"name":"Tennessee Center for AIDS Research, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LaToya","family":"Hannah","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangeeta","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Jeffrey","family":"Carr","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James G","family":"Terry","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi J","family":"Silver","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition , Nashville, Vanderbilt University Medical Center, TN 37232 ,","place":["USA"]},{"name":"Veterans Affairs Tennessee Valley Healthcare System , Nashville, TN 37232 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D","family":"Simmons","sequence":"additional","affiliation":[{"name":"Tennessee Center for AIDS Research, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Mashayekhi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spyros A","family":"Kalams","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]},{"name":"Tennessee Center for AIDS Research, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]},{"name":"Center for Translational Immunology and Infectious Diseases, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Mallal","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]},{"name":"Tennessee Center for AIDS Research, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]},{"name":"Center for Translational Immunology and Infectious Diseases, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]},{"name":"Insitute for Immunology and Infectious Diseases, Murdoch University , Perth, WA 6150 ,","place":["Australia"]},{"name":"Vanderbilt Technologies for Advanced Genomics, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A","family":"Kropski","sequence":"additional","affiliation":[{"name":"Veterans Affairs Tennessee Valley Healthcare System , Nashville, TN 37232 ,","place":["USA"]},{"name":"Department of Medicine, Division of Allergy and Pulmonology, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]},{"name":"Department of Cell and Developmental Biology, Vanderbilt University , Nashville, TN 37232 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9159-5414","authenticated-orcid":false,"given":"Celestine N","family":"Wanjalla","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]},{"name":"Center for Translational Immunology and Infectious Diseases, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R","family":"Koethe","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]},{"name":"Veterans Affairs Tennessee Valley Healthcare System , Nashville, TN 37232 ,","place":["USA"]},{"name":"Center for Translational Immunology and Infectious Diseases, Vanderbilt University Medical Center , Nashville, TN 37232 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2024,5,31]]},"reference":[{"issue":"11","key":"2024121723513759200_dgae369-B1","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1161\/CIRCULATIONAHA.117.033369","article-title":"Global 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