{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T17:02:52Z","timestamp":1785603772611,"version":"3.56.0"},"reference-count":12,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T00:00:00Z","timestamp":1718236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Primary hyperparathyroidism (PHPT) has initially been implicated in adverse maternal and neonatal outcomes, while subsequent population studies have failed to show an association.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This work aimed to compare maternal, pregnancy, and neonatal outcomes in patients with and without PHPT.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective matched-cohort study (2005-2020) was conducted at an integrated health-care delivery system in Southern California. Women aged 18 to 44 years were included. Patients with a biochemical diagnosis of PHPT were matched 1:3 with eucalcemic controls (non-PHPT). Main outcome measures included achievement of pregnancy, pregnancy outcomes (including rates of abortion, maternal complications), and neonatal outcomes (including hypocalcemia, need for intensive care).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The cohort comprised 386 women with PHPT and 1158 age-matched controls. Pregnancy rates between PHPT and control groups were similar (10.6% vs 12.8%). The adjusted rate ratio of pregnancy was 0.89 (95% CI, 0.64-1.24) (PHPT vs non-PHPT). Twenty-nine pregnancies occurred in women with coexisting PHPT and 191 pregnancies occurred in controls, resulting in 23 (79.3%) and 168 (88.0%) live births, respectively (P = .023). Neonatal outcomes were similar. Live birth rates were similar (86.4%, 80%, 79.2%) for those undergoing parathyroidectomy prior (n = 22), during (n = 5), or after pregnancy\/never (n = 24). Among patients who underwent parathyroidectomy during pregnancy, no spontaneous abortions occurred in women entering pregnancy with peak calcium less than 11.5 mg\/dL (2.9 mmol\/L).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>We observed no difference in pregnancy rates between women with or without PHPT. Performing parathyroidectomy before pregnancy or during the second trimester appears to be a safe and successful strategy, and adherence to this strategy may be most critical for patients with higher calcium levels (\u226511.5 mg\/dL [2.9 mmol\/L]).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgae409","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T10:23:14Z","timestamp":1718274194000},"page":"1427-1433","source":"Crossref","is-referenced-by-count":4,"title":["Fertility and Pregnancy Outcomes in Primary Hyperparathyroidism: Observations From a Large Insured Population"],"prefix":"10.1210","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7688-7790","authenticated-orcid":false,"given":"Vivek R","family":"Sant","sequence":"first","affiliation":[{"name":"Division of Endocrine Surgery, UT Southwestern Medical Center , Dallas, TX 75390 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Research and Evaluation, Kaiser Permanente Southern California , Pasadena, CA 91101 ,","place":["USA"]},{"name":"Kaiser Permanente Bernard J. Tyson School of Medicine , Pasadena, CA 91101 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengnan M","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Research and Evaluation, Kaiser Permanente Southern California , Pasadena, CA 91101 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette L","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Research and Evaluation, Kaiser Permanente Southern California , Pasadena, CA 91101 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denison S","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Research and Evaluation, Kaiser Permanente Southern California , Pasadena, CA 91101 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel K","family":"Case","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Bernard J. Tyson School of Medicine , Pasadena, CA 91101 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Ji","family":"Seo","sequence":"additional","affiliation":[{"name":"Section of Endocrine Surgery, UCLA David Geffen School of Medicine , Los Angeles, CA 90095 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip I","family":"Haigh","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kaiser Permanente Los Angeles Medical Center , Los Angeles, CA 90027 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Janzen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, UCLA David Geffen School of Medicine , Los Angeles, CA 90095 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7907-4245","authenticated-orcid":false,"given":"Michael W","family":"Yeh","sequence":"additional","affiliation":[{"name":"Section of Endocrine Surgery, UCLA David Geffen School of Medicine , Los Angeles, CA 90095 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2024,6,13]]},"reference":[{"issue":"1","key":"2025042208270664300_dgae409-B1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1530\/EJE-13-0966","article-title":"Pregnancy outcomes in women with primary hyperparathyroidism","volume":"171","author":"Abood","year":"2014","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"2025042208270664300_dgae409-B2","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1210\/jc.2012-4022","article-title":"Incidence and prevalence of primary hyperparathyroidism in a racially mixed population","volume":"98","author":"Yeh","year":"2013","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"issue":"5","key":"2025042208270664300_dgae409-B3","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1210\/jc.2015-1110","article-title":"Pregnancy outcomes in women with primary Hyperparathyroidism","volume":"100","author":"Hirsch","year":"2015","journal-title":"J Clin Endocrinol Metabol"},{"issue":"1","key":"2025042208270664300_dgae409-B4","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0002-9610(98)00302-X","article-title":"Hyperparathyroidism and pregnancy","volume":"177","author":"Kort","year":"1999","journal-title":"Am J Surg"},{"issue":"1","key":"2025042208270664300_dgae409-B5","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1365-2265.2008.03495.x","article-title":"Hyperparathyroidism during pregnancy and the effect of rising calcium on pregnancy loss: a call for earlier intervention","volume":"71","author":"Norman","year":"2009","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"3","key":"2025042208270664300_dgae409-B6","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/0002-9610(76)90127-6","article-title":"Hyperparathyroidism during pregnancy","volume":"131","author":"Delmonico","year":"1976","journal-title":"Am J Surg"},{"issue":"6","key":"2025042208270664300_dgae409-B7","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/00006254-200206000-00022","article-title":"Primary hyperparathyroidism in pregnancy: evidence-based management","volume":"57","author":"Schnatz","year":"2002","journal-title":"Obstet Gynecol Surv"},{"issue":"3","key":"2025042208270664300_dgae409-B8","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1097\/AOG.0b013e3181660c1b","article-title":"Prevalence and co-occurrence of pelvic floor disorders in community-dwelling women","volume":"111","author":"Lawrence","year":"2008","journal-title":"Obstetrics & Gynecology"},{"issue":"6","key":"2025042208270664300_dgae409-B9","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.surg.2011.09.025","article-title":"Population-level predictors of persistent hyperparathyroidism","volume":"150","author":"Yeh","year":"2011","journal-title":"Surgery"},{"key":"2025042208270664300_dgae409-B10","doi-asserted-by":"publisher","DOI":"10.18738\/T8\/826CRK","article-title":"Supplementary material for manuscript (From Fertility and Pregnancy Outcomes in Primary Hyperparathyroidism: Observations From a Large Insured Population)","author":"Sant","year":"2024","journal-title":"Texas Data Repository, V1"},{"issue":"6","key":"2025042208270664300_dgae409-B11","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.7326\/0003-4819-61-6-1109","article-title":"Neonatal tetany","volume":"61","author":"Hutghin","year":"1964","journal-title":"Ann Intern Med"},{"issue":"13","key":"2025042208270664300_dgae409-B12","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1056\/NEJM196209272671302","article-title":"Hyperparathyroidism in relation to pregnancy","volume":"267","author":"Ludwig","year":"1962","journal-title":"N Engl J Med"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgae409\/58319414\/dgae409.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/110\/5\/1427\/58319414\/dgae409.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/110\/5\/1427\/58319414\/dgae409.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T12:27:22Z","timestamp":1745324842000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/110\/5\/1427\/7692186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,13]]},"references-count":12,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,6,13]]},"published-print":{"date-parts":[[2025,4,22]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgae409","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,5]]},"published":{"date-parts":[[2024,6,13]]}}}