{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:03:33Z","timestamp":1791644613091,"version":"4.3.4"},"reference-count":38,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To describe the natural history of inhibin B throughout life according to sex, age, and pubertal development.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Based on serum samples from 2707 healthy controls aged 0 to 80 years, sex- and age-specific reference ranges of inhibin B concentrations were constructed. Concentrations were evaluated according to pubertal development and use of oral contraceptives (OCs). Also, measurements from 42 patients with Klinefelter syndrome were included.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In both sexes, inhibin B concentrations were high during minipuberty, decreased in childhood, and significantly increased from Tanner stages B1 to B3 (peak: B4) in females and from G1 to G3 (peak: G3) in males. Despite variations in menstruating females, inhibin B concentrations remained relatively constant after puberty until becoming unmeasurable at menopause. Despite a modest decrease, the inhibin B concentration in males remained relatively high from puberty onward. At any age, males had highest concentrations. Inhibin B SD scores were lower in OC users (median SD score = \u22120.88) than in nonusers (SD score = 0.35), P &amp;lt; .001. In patients with Klinefelter syndrome, inhibin B concentrations spanned the reference range until approximately 15 years of age, where they decreased to subnormal or unmeasurable levels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Valuable sex- and age-specific reference data for inhibin B concentrations were provided. In OC users, decreased concentrations of inhibin B underlined the ovaries as the only place of inhibin B production. In patients with Klinefelter syndrome, the decline in inhibin B concentrations at puberty underlined the shift in regulation of inhibin B production at pubertal onset.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgae439","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T11:49:52Z","timestamp":1719402592000},"page":"70-77","source":"Crossref","is-referenced-by-count":13,"title":["Serum Concentrations of Inhibin B in Healthy Females and Males Throughout Life"],"prefix":"10.1210","volume":"110","author":[{"given":"Anna","family":"Borelli-Kj\u00e6r","sequence":"first","affiliation":[{"name":"Department of Growth and Reproduction, Copenhagen University Hospital\u2014Rigshospitalet , DK-2100 Copenhagen ,","place":["Denmark"]},{"name":"International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen , DK-2100 Copenhagen 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