{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:12:32Z","timestamp":1753888352529,"version":"3.41.0"},"reference-count":46,"publisher":"The Endocrine Society","issue":"6","license":[{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"National Institutes of Health\u2019s National Research Service Award","award":["T32 HD 104612"],"award-info":[{"award-number":["T32 HD 104612"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD034568","R24ES030894","R01HD096032","R01ES031065","P30 ES000002"],"award-info":[{"award-number":["R01HD034568","R24ES030894","R01HD096032","R01ES031065","P30 ES000002"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Evidence suggests that exposure to per- and polyfluoroalkyl substances (PFAS) increases the risk of developing cardiometabolic disease risk factors. Limited research has evaluated associations between PFAS, assessed during pregnancy, a sensitive window for maternal endocrine effects, and long-term maternal adiposity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Estimate associations of early pregnancy measures of individual PFAS, and PFAS mixtures, with maternal adiposity in midlife.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We studied 547 Project Viva participants with measures of early pregnancy (mean gestation 10.0 weeks; mean age 32.5 years) plasma concentrations of 6 PFAS and midlife adiposity outcomes (mean follow-up 17.7 years; mean age 50.7 years), including weight, waist circumference (WC), trunk fat mass (TFM), and total body fat mass (TBFM). We used linear regression and Bayesian Kernel Machine Regression (BKMR).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Linear regression estimated higher midlife weight per doubling of perfluorooctane sulfonate (PFOS) (3.8\u2005kg [95% CI: 1.6, 5.9]) and 2-(N-ethyl-perfluorooctane sulfonamido) acetate (2.3\u2005kg [95% CI: 0.9, 3.7]). BKMR analyses of single PFAS plasma concentrations (comparing the 25th percentile concentration to the 75th percentile) showed a positive association between PFOS and midlife adiposity (weight: 7.7\u2005kg [95% CI: 4.0, 11.5]; TFM: 1.2\u2005kg [95% CI: 0.0, 2.3]; TBFM: 3.0\u2005kg [95% CI: 0.8, 5.2]), but inverse associations with perfluorononanoate (weight: \u22126.0\u2005kg [95% CI: \u22128.5, \u22123.5]; WC: \u22121.8\u2005cm [95% CI: \u22123.2, \u22120.3]; TFM: \u22120.8\u2005kg [95% CI: \u22121.5, \u22120.1]; TBFM: \u22121.4\u2005kg [95% CI: \u22122.7, \u22120.3]) and perfluorohexane sulfonate (TFM: \u22120.8\u2005kg [95% CI: \u22121.5, \u22120.1]; TBFM: \u22121.4\u2005kg [95% CI: \u22122.6, \u22120.2]). No associations were observed with the overall PFAS mixture.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Select PFAS, assessed in pregnancy, may differentially affect maternal midlife adiposity, influencing later-life maternal cardiometabolic health.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgae542","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T23:51:19Z","timestamp":1725580279000},"page":"e1966-e1974","source":"Crossref","is-referenced-by-count":3,"title":["Early Pregnancy Plasma Per- and Polyfluoroalkyl Substances (PFAS) and Maternal Midlife Adiposity"],"prefix":"10.1210","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8835-6997","authenticated-orcid":false,"given":"Jordan A","family":"Burdeau","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Harvard T.H. 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Chan School of Public Health , Boston, MA 02215 ,","place":["USA"]},{"name":"Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Massachusetts General Hospital , Boston, MA 02114 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma V","family":"Preston","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Harvard T.H. Chan School of Public Health , Boston, MA 02215 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-France","family":"Hivert","sequence":"additional","affiliation":[{"name":"Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute , Boston, MA 02215 ,","place":["USA"]},{"name":"Diabetes Unit, Massachusetts General Hospital , Boston, MA 02114 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Oken","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Harvard T.H. Chan School of Public Health , Boston, MA 02215 ,","place":["USA"]},{"name":"Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute , Boston, MA 02215 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9796-7482","authenticated-orcid":false,"given":"Antonia M","family":"Calafat","sequence":"additional","affiliation":[{"name":"Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention , Atlanta, GA 30341 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheryl L","family":"Rifas-Shiman","sequence":"additional","affiliation":[{"name":"Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute , Boston, MA 02215 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ami R","family":"Zota","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, Columbia University Mailman School of Public Health , New York, NY 10032 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3589-5169","authenticated-orcid":false,"given":"Tamarra","family":"James-Todd","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard T.H. 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