{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T17:58:19Z","timestamp":1789235899812,"version":"build-2803163510"},"reference-count":37,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Ministry of Health's","award":["PI13\/01335"],"award-info":[{"award-number":["PI13\/01335"]}]},{"name":"Spanish Ministry of the Economy Industry and Competitiveness","award":["DEP2016-78377-R"],"award-info":[{"award-number":["DEP2016-78377-R"]}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Funds","doi-asserted-by":"publisher","award":["ERDF 2014-2020"],"award-info":[{"award-number":["ERDF 2014-2020"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Regional Government of Navarra's Department of Economic Development","award":["0011-1365-2019-000152"],"award-info":[{"award-number":["0011-1365-2019-000152"]}]},{"name":"Regional Government of Navarra's Department of Economic Development","award":["0011-1365-2020-000243"],"award-info":[{"award-number":["0011-1365-2020-000243"]}]},{"DOI":"10.13039\/501100004837","name":"Spanish Ministry of Science and Innovation","doi-asserted-by":"publisher","award":["FJC2018-037925-I"],"award-info":[{"award-number":["FJC2018-037925-I"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"name":"J.M.A.A.","award":["MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033"]}]},{"name":"European Union Next Generation","award":["FJC2020-044453-I"],"award-info":[{"award-number":["FJC2020-044453-I"]}]},{"name":"Spanish Ministry of Economy and Competitiveness","award":["BES-2017-080770"],"award-info":[{"award-number":["BES-2017-080770"]}]},{"name":"Margarita Salas","award":["RCMS-22-KIAO1C-24-GSMTDX"],"award-info":[{"award-number":["RCMS-22-KIAO1C-24-GSMTDX"]}]},{"name":"Margarita Salas","award":["MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033"]}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Exercise reduces adiposity, but its influence on bone marrow fat fraction (BMFF) is unknown; nor is it known whether a reduction in liver fat content mediates this reduction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This work aimed to determine whether incorporating exercise into a lifestyle program reduces the lumbar spine (LS) BMFF and to investigate whether changes in liver fat mediate any such effect.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Ancillary analysis of a 2-arm, parallel, nonrandomized clinical trial was conducted at primary care centers in Vitoria-Gasteiz, Spain. A total of 116 children with overweight\/obesity were assigned to a 22-week family-based lifestyle program (control group [n = 57]) or the same program plus an exercise intervention (exercise group [n = 59]). The compared interventions consisted of a family-based lifestyle program (two 90-minute sessions\/month) and the same program plus supervised exercise (three 90-minute sessions\/week). The primary outcome examined was the change in LS-BMFF between baseline and 22 weeks, as estimated by magnetic resonance imaging. The effect of changes in hepatic fat on LS-BMFF were also recorded.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Mean weight loss difference between groups was 1.4 \u00b1 0.5\u2005kg in favor of the exercise group. Only the children in the exercise group experienced a reduction in LS-BMFF (effect size [Cohen d] \u22120.42; CI, \u22120.86 to \u22120.01). Importantly, 40.9% of the reductions in LS-BMFF were mediated by changes in percentage hepatic fat (indirect effect: \u03b2=\u22120.104; 95% CI, \u22120.213 to \u22120.019). The effect of changes in hepatic fat on LS-BMFF was independent of weight loss.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The addition of exercise to a family-based lifestyle program designed to reduce cardiometabolic risk improves bone health by reducing LS-BMFF in children with overweight or obesity. This beneficial effect on bone marrow appears to be mediated by reductions in liver fat.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgae547","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T22:14:37Z","timestamp":1723068877000},"page":"847-854","source":"Crossref","is-referenced-by-count":7,"title":["Effects of Exercise on Bone Marrow Adipose Tissue in Children With Overweight\/Obesity: Role of Liver Fat"],"prefix":"10.1210","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4334-3287","authenticated-orcid":false,"given":"Idoia","family":"Labayen","sequence":"first","affiliation":[{"name":"Institute for Sustainability & Food Chain Innovation (IS-FOOD), Department of Health Sciences, Public University of Navarre , 31006 Pamplona, Navarre ,","place":["Spain"]},{"name":"IdiSNA, Navarra Institute for Health Research , 31006 Pamplona, Navarre ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERobn), Instituto de Salud Carlos III , 28029 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Cadenas-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Institute for Sustainability & Food Chain Innovation (IS-FOOD), Department of Health Sciences, Public University of Navarre , 31006 Pamplona, Navarre ,","place":["Spain"]},{"name":"IdiSNA, Navarra Institute for Health Research , 31006 Pamplona, Navarre ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERobn), Instituto de Salud Carlos III , 28029 Madrid ,","place":["Spain"]},{"name":"Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada , 18007 Granada ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Idoate","sequence":"additional","affiliation":[{"name":"Radiology Department, Mutua Navarra, Department of Health Sciences, Public University of Navarre , 31012 Pamplona, Navarre ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4020-0256","authenticated-orcid":false,"given":"Luis","family":"Gracia-Marco","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERobn), Instituto de Salud Carlos III , 28029 Madrid ,","place":["Spain"]},{"name":"Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada , 18007 Granada ,","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Biosanitaria, ibs.Granada , 18012 Granada ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Medrano","sequence":"additional","affiliation":[{"name":"Institute for Sustainability & Food Chain Innovation (IS-FOOD), Department of Health Sciences, Public University of Navarre , 31006 Pamplona, Navarre ,","place":["Spain"]},{"name":"IdiSNA, Navarra Institute for Health Research , 31006 Pamplona, Navarre ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERobn), Instituto de Salud Carlos III , 28029 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor Manuel","family":"Alfaro-Magallanes","sequence":"additional","affiliation":[{"name":"Institute for Sustainability & Food Chain Innovation (IS-FOOD), Department of Health Sciences, Public University of Navarre , 31006 Pamplona, Navarre ,","place":["Spain"]},{"name":"IdiSNA, Navarra Institute for Health Research , 31006 Pamplona, Navarre ,","place":["Spain"]},{"name":"Department of Health and Human Performance, Faculty of Physical Activity and Sport Sciences, LFE Research Group, Universidad Polit\u00e9cnica de Madrid , 28040 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan M A","family":"Alcantara","sequence":"additional","affiliation":[{"name":"Institute for Sustainability & Food Chain Innovation (IS-FOOD), Department of Health Sciences, Public University of Navarre , 31006 Pamplona, Navarre ,","place":["Spain"]},{"name":"IdiSNA, Navarra Institute for Health Research , 31006 Pamplona, Navarre ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERobn), Instituto de Salud Carlos III , 28029 Madrid 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