{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T13:34:30Z","timestamp":1773322470732,"version":"3.50.1"},"reference-count":40,"publisher":"The Endocrine Society","issue":"3","funder":[{"DOI":"10.13039\/100030692","name":"Intramural Research Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH R01 HD27503"],"award-info":[{"award-number":["NIH R01 HD27503"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH K24 HD\/DK01357"],"award-info":[{"award-number":["NIH K24 HD\/DK01357"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH UL1TR001857"],"award-info":[{"award-number":["NIH UL1TR001857"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RR024153"],"award-info":[{"award-number":["RR024153"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"a dkNET New Investigator Pilot Program in Bioinformatics"},{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2022H1D3A2A01063552"],"award-info":[{"award-number":["2022H1D3A2A01063552"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Graduate Research Fellowship Program","award":["DGE 1840340"],"award-info":[{"award-number":["DGE 1840340"]}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DGE 1840340"],"award-info":[{"award-number":["DGE 1840340"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006143","name":"Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006143","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>The gold-standard clamp measurements for insulin sensitivity (cSI), \u03b2-cell function (cBCF), and disposition index (cDI = cSI\u2005\u00d7\u2005cBCF) are not practical in large-scale studies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We sought to 1) validate a mathematical model-derived DI from oral glucose tolerance tests (OGTT) with insulin (mDI) and without (mDI-woI) against cDI and oral disposition index (oDI) and 2) evaluate the ability of the novel indices to detect prediabetes and type 2 diabetes (T2D).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We carried out a secondary analysis of previously reported cross-sectional observational studies. The Insulin Sensitivity and Secretion mathematical model for glucose-insulin dynamics was applied to 5-point and 3-point OGTTs synchronized with hyperinsulinemic-euglycemic and hyperglycemic clamps from 130 youth with obesity (68 normal glucose tolerance [NGT], 33 impaired glucose tolerance [IGT], 29 T2D).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Model-derived DI correlated well with clamp DI (R = 0.76 [logged]). Between NGT and IGT, mDI and mDI-woI decreased more than oDI and cDI, (60% and 59% vs 29% and 27%), and by receiver operating characteristic analysis were superior at detecting IGT compared with oDI and cDI (area under the curve [AUC] 0.88-0.87 vs 0.68-0.65), as was mean glucose (AUC 0.87).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>mDI-woI is better than oDI or the labor-intensive cDI for detecting dysglycemia in obese youth. Bypassing insulin measurements with mDI-woI from the OGTT provides a cost-effective approach for large-scale epidemiological studies of dysglycemia in youth.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgae582","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T23:28:39Z","timestamp":1724369319000},"page":"706-714","source":"Crossref","is-referenced-by-count":3,"title":["A Mathematical Model-Derived Disposition Index Without Insulin Validated in Youth With Obesity"],"prefix":"10.1210","volume":"110","author":[{"given":"Joon","family":"Ha","sequence":"first","affiliation":[{"name":"Department of Mathematics, Howard University , Washington, DC 20059 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Exercise Science, David B. Falk College of Sport and Human Dynamics, Syracuse University , Syracuse, NY 13244 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9291-6574","authenticated-orcid":false,"given":"Max","family":"Springer","sequence":"additional","affiliation":[{"name":"Department of Mathematics, University of Maryland , College Park, MD 20742 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaryan","family":"Chhabra","sequence":"additional","affiliation":[{"name":"Department of Biology, Indian Institute of Science Education and Research , Pune, Maharashtra 411008 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie T","family":"Chung","sequence":"additional","affiliation":[{"name":"Section on Pediatric Diabetes, Obesity, and Metabolism, NIDDK, NIH , Bethesda, MD 20892 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne E","family":"Sumner","sequence":"additional","affiliation":[{"name":"Intramural Research Program, National Institute on Minority Health and Health Disparities (NIMHD), National Institutes of Health , Bethesda, MD 20892 ,","place":["USA"]},{"name":"Section on Ethnicity and Health, Diabetes Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health , Bethesda, MD 20892 ,","place":["USA"]},{"name":"Hypertension in Africa Research Team, North-West University, Potchefstroom , North-West 2520 ,","place":["South Africa"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8372-5941","authenticated-orcid":false,"given":"Arthur S","family":"Sherman","sequence":"additional","affiliation":[{"name":"Laboratory of Biological Modeling, NIDDK, NIH , Bethesda, MD 20892 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1528-9324","authenticated-orcid":false,"given":"Silva","family":"Arslanian","sequence":"additional","affiliation":[{"name":"Center for Pediatric Research in Obesity and Metabolism, UPMC Children's Hospital of Pittsburgh , Pittsburgh, PA 15224 ,","place":["USA"]},{"name":"Division of Pediatric Endocrinology and Metabolism, UPMC Children's Hospital of Pittsburgh , Pittsburgh, PA 15224 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"issue":"11","key":"2025021815503906400_dgae582-B1","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.2337\/diab.42.11.1663","article-title":"Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. 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