{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:26:15Z","timestamp":1791347175189,"version":"4.3.1"},"reference-count":25,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Rigshospitalets Research Counsil","award":["E-22717-21"],"award-info":[{"award-number":["E-22717-21"]}]},{"DOI":"10.13039\/501100008269","name":"L\u00e6ge Sofus Carl Emil Friis og hustru","doi-asserted-by":"publisher","award":["F-23936-01"],"award-info":[{"award-number":["F-23936-01"]}],"id":[{"id":"10.13039\/501100008269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003035","name":"Aase og Ejnar Danielsens","doi-asserted-by":"publisher","award":["20-10-0367"],"award-info":[{"award-number":["20-10-0367"]}],"id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Danish Centre for Endocrine Disrupting"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Female minipuberty is characterized by complex dynamics of circulating reproductive hormones, while the relationship between ovarian and uterine morphology and reproductive hormones remains to be elucidated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This work aimed to investigate the association between reproductive hormones and ovarian as well as uterine morphology by transabdominal ultrasound scan (TAUS) at minipuberty.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A secondary analysis was conducted from The Copenhagen Analgesic Study (COPANA) (ClinicalTrials.gov NCT04369222) of healthy infant girls (n = 302, aged 3.4 months [0.4] mean [\u00b1SD]: mamma tissue diameter [mm], n = 300). TAUS: uterine volume (n = 230), endometrial thickness (n = 255), ovarian volume, antral follicle count (total\/2-4\u2005mm\/\u22655\u2005mm) (n = 203). Blood samples (n = 269\/302 = 89%): antim\u00fcllerian hormone (AMH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), inhibin B (immunoassays), progesterone (PROG), androstenedione (Adione), testosterone (T), estrone (E1), estradiol (E2) (liquid chromatography\u2013tandem mass spectrometry). Statistics: Pearson\/Spearman correlation coefficient (parametric\/nonparametric data).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Total follicle count correlated positively with ovarian volume (r = 0.606; P &amp;lt; .001), AMH (r = 0.378; P &amp;lt; .001), inhibin B (r = 0.251; P &amp;lt; .001), and negatively with FSH concentrations (r = \u22120.327; P &amp;lt; .001). Larger follicles (\u22655\u2005mm) correlated positively with AMH (r = 0.264; P &amp;lt; .001), inhibin B (r = 0.230; P = .002), E1 (r = 0.209; P = .004), E2 (r = 0.269; P &amp;lt; .001), PROG (r = 0.160; P = .031), and T (r = 0.210; P = .004) and negatively with FSH (r = \u22120.183; P = .015). Circulating E1 and E2 levels correlated with the size of estrogen-responsive tissue sizes: E2 vs uterine volume (r = 0.134; P = .054), E2 vs endometrial thickness (r = 0.155; P = .020), E1 and E2 vs mammary tissue diameter (r = 0.213 and r = 0.198, respectively; both P &amp;lt; .001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Correlations between reproductive hormones and the number of antral follicles suggest that negative feedback in the female hypothalamic-pituitary-gonadal axis is established during minipuberty, with ovarian activity promoting uterine and glandular breast tissue growth. We provide normative data of infant ovarian and uterine morphology directly implementable to a clinical setting.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgae678","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T11:29:06Z","timestamp":1727436546000},"page":"1015-1022","source":"Crossref","is-referenced-by-count":16,"title":["Ovarian and Uterine Morphology in Minipuberty: Associations With Reproductive Hormones: a COPANA Study of 302 Girls"],"prefix":"10.1210","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7999-548X","authenticated-orcid":false,"given":"Margit Bistrup","family":"Fischer","sequence":"first","affiliation":[{"name":"Department of Growth and Reproduction, Copenhagen University Hospital \u2013 Rigshospitalet , 2100 Copenhagen \u00d8 ,","place":["Denmark"]},{"name":"International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital \u2013 Rigshospitalet , 2100 Copenhagen \u00d8 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gylli","family":"Mola","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction, Copenhagen University Hospital \u2013 Rigshospitalet , 2100 Copenhagen \u00d8 ,","place":["Denmark"]},{"name":"International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital \u2013 Rigshospitalet , 2100 Copenhagen \u00d8 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ane Lille\u00f8re","family":"Rom","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Copenhagen University Hospital \u2013 Rigshospitalet , 2100 Copenhagen \u00d8 ,","place":["Denmark"]},{"name":"Research Unit of Gynecology and Obstetrics, Department of Clinical Research, University of Southern Denmark , 5000 Odense ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3180-9879","authenticated-orcid":false,"given":"Hanne","family":"Frederiksen","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction, Copenhagen University Hospital \u2013 Rigshospitalet , 2100 Copenhagen \u00d8 ,","place":["Denmark"]},{"name":"International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital \u2013 Rigshospitalet , 2100 Copenhagen \u00d8 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trine Holm","family":"Johannsen","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction, Copenhagen University Hospital \u2013 Rigshospitalet , 2100 Copenhagen \u00d8 ,","place":["Denmark"]},{"name":"International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital \u2013 Rigshospitalet , 2100 Copenhagen \u00d8 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5598-5773","authenticated-orcid":false,"given":"Karin","family":"Sundberg","sequence":"additional","affiliation":[{"name":"Center of Fetal Medicine and Pregnancy, Department of Obstetrics, Copenhagen University Hospital \u2013 Rigshospitalet , 2100 Copenhagen \u00d8 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne Kristine","family":"Hegaard","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Copenhagen University Hospital \u2013 Rigshospitalet , 2100 Copenhagen \u00d8 ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, University of Copenhagen , 2200 Copenhagen N 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