{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T14:26:20Z","timestamp":1779200780289,"version":"3.51.4"},"reference-count":53,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>As a novel parameter for risk prediction, artery stiffness may hold promise in refining risk assessment strategies, guiding therapeutic interventions, and ultimately improving cardiovascular outcomes in patients with primary aldosteronism (PA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective and Methods<\/jats:title>\n                  <jats:p>To investigate the correlation between brachial-ankle pulse wave velocity (baPWV), an indicator of arterial stiffness, and the occurrence of major adverse cardiovascular events (MACEs) in patients with PA under a primary prevention design.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among the 830 patients included in the final analysis, 113 (13.6%) developed incident MACEs over a median follow-up period of 5.8 years, with a crude rate of 23.2 per 1000 person-years. Multivariable Cox proportional hazards analyses revealed that baPWV was an independent risk factor for incident MACEs, with an adjusted hazard ratio (HR) of 1.01 (P = .028). The generalized additive model identified a cut-off value of 2000 cm\/s for baPWV, which was independently associated with incident MACEs, with a HR of 1.81 (P = .024), while accounting for mortality as a competing risk. Subgroup analyses revealed that PA patients who were mineralocorticoid receptor antagonist users and had high baPWV had a significantly higher risk of incident MACEs (HR = 3.34; P &amp;lt; .001), whereas the risk was not significant in patients who underwent adrenalectomy (P = .062). Furthermore, the addition of baPWV to the cardiovascular Framingham risk score significantly improved the category-free net reclassification index (0.308, P &amp;lt; .001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our study found that 13.6% of patients with PA developed MACEs after a median follow-up of 5.8 years. Our findings highlight the potential utility of baPWV as a tool for risk stratification in patients with PA in primary prevention, whereas adrenalectomy appears to mitigate this risk regardless of baPWV. The measurement of baPWV could be a valuable addition to hypertension screening programs for primary prevention, providing additional predictive information for the potential occurrence of MACEs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgae683","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T08:19:25Z","timestamp":1728634765000},"page":"1896-1905","source":"Crossref","is-referenced-by-count":7,"title":["Arterial Stiffness Associated With Long-term Major Adverse Cardiac Events in Patients With Primary Aldosteronism"],"prefix":"10.1210","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7935-0991","authenticated-orcid":false,"given":"Vin-Cent","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital , Taipei 100225 ,","place":["Taiwan"]},{"name":"Internal Medicine, Primary Aldosteronism Center (PAC) of National Taiwan University Hospital , 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Primary Aldosteronism Center (PAC) of National Taiwan University Hospital , Taipei 100225 ,","place":["Taiwan"]},{"name":"TAIPAI, Taiwan Primary Aldosteronism Investigation (TAIPAI) Study Group , Taipei 100225 ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2090-1757","authenticated-orcid":false,"given":"Shuo-Meng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology, College of Medicine, National Taiwan University , Taipei 100225 ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeff S","family":"Chueh","sequence":"additional","affiliation":[{"name":"TAIPAI, Taiwan Primary Aldosteronism Investigation (TAIPAI) Study Group , Taipei 100225 ,","place":["Taiwan"]},{"name":"Department of Urology, College of Medicine, National Taiwan University , Taipei 100225 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