{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T22:40:06Z","timestamp":1750804806943,"version":"3.41.0"},"reference-count":32,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T00:00:00Z","timestamp":1728086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Radius quantitative ultrasound measurement utilizing portable low-frequency (VLF) axial transmission ultrasound for assessing properties of radius cortical bone revealed a possible role as a screening tool prior to dual-energy x-ray absorptiometry (DXA) to evaluate fragility fracture in some studies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To evaluate this portable ultrasound device as a screening tool of skeletal fragility in patients with primary hyperparathyroidism (PHPT).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We enrolled 117 postmenopausal women with PHPT. Every subject had a DXA of femur, lumbar spine, nondominant distal one-third radius section, trabecular bone score (TBS) measurement, VLF with a portable device, and spine x-ray.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The mean age of the patients was 68 \u00b1 10 years. The measurement of agreement between radius DXA and VLF was: K = 0.43, P &amp;lt; .001. A lower radius ultrasound T-score, also adjusted for years since menopause and body mass index, was associated with DXA-identified osteoporosis at lumbar and\/or femoral neck sites: odds ratio (OR) = 1.852 (CI 1.08, 3.18). All fractures were associated with femoral neck T-score: OR = 1.89 (95% CI 1.24, 2.89), as well as with total hip T-score: OR = 1.65 (95% CI 1.09, 2.50), and years since menopause: OR = 1.25 (95% CI 1.02, 1.54).<\/jats:p>\n                  <jats:p>Morphometric vertebral fractures were associated with years since menopause: OR = 1.28 (95% CI 1.02, 1.61), femoral neck T-score OR = 1.96 (95% CI 1.227, 3.135), total hip T-score OR = 1.64 (95% CI 1.04, 2.60), TBS OR = 0.779 (95% CI 0.60-0.99), both ultradistal radius T-score: OR = 1.50 (95% CI 1.05, 2.156), and radius ultrasound T-score: OR = 1.67 (95% CI 1.09, 2.56).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>VLF could be used for screening purposes prior to DXA to evaluate PHPT fracture risk, only in conditions in which DXA measurement cannot be performed.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgae695","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T12:12:36Z","timestamp":1728043956000},"page":"1974-1979","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Radius Axial Low-Frequency Ultrasound Velocity and Bone Fragility in Primary Hyperparathyroidism"],"prefix":"10.1210","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3088-0673","authenticated-orcid":false,"given":"Jessica","family":"Pepe","sequence":"first","affiliation":[{"name":"Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, \u201cSapienza\u201d University of Rome , 00161 Rome ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano","family":"Colangelo","sequence":"additional","affiliation":[{"name":"Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, \u201cSapienza\u201d University of Rome , 00161 Rome 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