{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T01:25:44Z","timestamp":1783041944258,"version":"3.54.6"},"reference-count":34,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:00:00Z","timestamp":1728950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG005407"],"award-info":[{"award-number":["R01 AG005407"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AR35582"],"award-info":[{"award-number":["R01 AR35582"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AR35583"],"award-info":[{"award-number":["R01 AR35583"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AR35584"],"award-info":[{"award-number":["R01 AR35584"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG005394"],"award-info":[{"award-number":["R01 AG005394"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG027574"],"award-info":[{"award-number":["R01 AG027574"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG027576"],"award-info":[{"award-number":["R01 AG027576"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>It is unknown if isolated low bone mineral density (BMD) \u201costeoporosis\u201d at the radius is associated with increased fracture risk, not only at the wrist but elsewhere, and whether it reflects more generalized skeletal fragility.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This work aimed to review the association of radius BMD and fracture risk, the epidemiology of wrist fractures, isolated osteoporosis at the radius, and the concordance between radial BMD and femoral neck BMD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We completed a narrative literature review on radius BMD and fracture risk and current recommendations for measurement of radial BMD. We updated results of radial BMD and fracture results from the Study of Osteoporotic Fractures over 20 years and examined the concordance of BMD at the distal and proximal radius with femoral neck BMD T scores.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Radius BMD is a robust predictor of all types of fractures including hip and wrist but there is insufficient evidence to suggest that radius BMD predicts wrist fractures better than fractures at other sites. Fractures of the wrist tend to occur in younger, healthier women compared with hip and spine fractures. Nevertheless, wrist fractures are associated with an increased risk of future fractures and represent a missed opportunity for intervention. On a population level, the discordance between radius BMD and femoral neck BMD is small. But women with isolated osteoporosis at the radius had biochemical and microarchitecture deterioration that were similar to women with hip osteoporosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Future research should address the clinical implications of isolated osteoporosis at the radius and whether treatment is warranted.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgae726","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T10:17:35Z","timestamp":1728987455000},"page":"e1-e7","source":"Crossref","is-referenced-by-count":8,"title":["New Challenges: Use and Interpretation of Radius Bone Mineral Density"],"prefix":"10.1210","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0752-4408","authenticated-orcid":false,"given":"Jane A","family":"Cauley","sequence":"first","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Pittsburgh , Pittsburgh, PA 15261 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Yung","family":"Lui","sequence":"additional","affiliation":[{"name":"Research Institute, California Pacific Medical Center , San Francisco, CA 94143 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5797-4947","authenticated-orcid":false,"given":"Meryl S","family":"LeBoff","sequence":"additional","affiliation":[{"name":"Endocrinology, Diabetes and Hypertension Division, Harvard Medical School, Brigham and Women's Hospital , Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0719-9801","authenticated-orcid":false,"given":"Nelson B","family":"Watts","sequence":"additional","affiliation":[{"name":"Mercy Health Osteoporosis and Bone Health Services , Cincinnati, OH 45236 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2024,10,15]]},"reference":[{"issue":"2","key":"2024121723524707200_dgae726-B1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.hcl.2012.02.001","article-title":"The epidemiology of distal radius fractures","volume":"28","author":"Nellans","year":"2012","journal-title":"Hand Clin"},{"issue":"3","key":"2024121723524707200_dgae726-B2","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/jbmr.2072","article-title":"Trends in fracture incidence: a population-based study over 20 years","volume":"29","author":"Amin","year":"2014","journal-title":"J Bone Miner Res"},{"issue":"1","key":"2024121723524707200_dgae726-B3","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1046\/j.1532-5415.2002.50014.x","article-title":"Distal radius fractures in older women: a 10-year follow-up study of descriptive characteristics and risk factors. 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