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Increased oxidative stress in T2D induces diabetic complications and may affect T2D bone fragility.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To investigate whether the levels of plasma F2-isoprostanes, a reliable oxidative stress marker, are associated with incident clinical fracture risk in older adults with diabetes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>An observational cohort study was conducted in a well-characterized cohort from Health, Aging, and Body Composition study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>Older Black and White ambulatory adults with baseline plasma F2-isoprostanes measurements (baseline age 70-79 years, T2D: N = 132; nondiabetes: N = 571) were selected from the study cohort of 3075 individuals. Risk of incident clinical fractures was assessed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In the Cox proportional hazard model with multivariate adjustments (including BMD, medications, and other risk factors), a 93% increase in incident clinical fracture risk was significantly associated with each SD increase in log plasma F2-isoprostanes in the T2D group (hazard ratio [HR] = 1.93 [95% CI, 1.26-2.9] P = .002), but there was no evidence of an association in the nondiabetes group (HR = 0.98 [95% CI 0.81-1.18] P = .79, P for interaction &amp;lt;.001). Log plasma F2-isoprostanes were moderately correlated with a decline in baseline total hip BMD (r = \u22120.25, P = .003), and with a 4-year decrease in total hip BMD (r = \u22120.28, P = .008) in T2D. There was no evidence of correlation between log plasma F2-isoprostanes and circulating glycoxidation markers or bone turnover markers in either group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Plasma F2-isoprostanes levels in individuals with diabetes are associated with increased incident clinical fracture risk independently of baseline BMD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgae788","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T04:20:38Z","timestamp":1731039638000},"page":"2299-2306","source":"Crossref","is-referenced-by-count":1,"title":["F2-Isoprostanes Are Associated With Increased Fracture Risk in Type 2 Diabetes"],"prefix":"10.1210","volume":"110","author":[{"given":"Bowen","family":"Wang","sequence":"first","affiliation":[{"name":"Rensselaer\u2013Icahn School of Medicine at Mount Sinai Center for 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