{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T03:46:18Z","timestamp":1790307978443,"version":"4.1.0"},"reference-count":74,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province, China","doi-asserted-by":"publisher","award":["2024JC-YBQN-0911"],"award-info":[{"award-number":["2024JC-YBQN-0911"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province, China","doi-asserted-by":"publisher","award":["2023-JC-YB-742"],"award-info":[{"award-number":["2023-JC-YB-742"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province, China","doi-asserted-by":"publisher","award":["2022JM-438"],"award-info":[{"award-number":["2022JM-438"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015401","name":"Key Research and Development Project of Shaanxi Province","doi-asserted-by":"publisher","award":["2023-ZDLSF-40"],"award-info":[{"award-number":["2023-ZDLSF-40"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Clinical Research Program of Air Force Medical University","award":["2023LC2320"],"award-info":[{"award-number":["2023LC2320"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Prevailing studies have shown the disruption effect of per- and polyfluoroalkyl substances (PFAS) on thyroid homeostasis. However, most studies have focused on individual thyroid hormones.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To explore the associations between PFAS exposures and thyroid homeostasis parameters.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 2386 adults from National Health and Nutrition Examination Survey (2007-2008 and 2011-2012) were included. Thyroid homeostasis parameters included central and peripheral thyroid hormone sensitivity, calculated by thyroid hormones. Multivariable survey-weighted linear regressions were performed to determine the association between PFAS exposure and thyroid homeostasis parameters. The weighted quantile sum (WQS) and the quantile g-computation (QGC) models were used to estimate the mixed effects of coexposures to PFAS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The ratio of free T3\/free T4 (FT3\/FT4) and the sum activity of peripheral deiodinases (SPINA-GD) were positively associated with perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid, perfluorononanoic acid, and perfluorohexane sulfonic acid, respectively. However, no significant associations were observed between PFAS exposure and central thyroid sensitivity parameters. PFAS coexposure was positively associated with FT3\/FT4 (\u03b2 = 0.013, P &amp;lt; .001) and SPINA-GD (\u03b2 = 1.230, P &amp;lt; .001) in WQS models. Consistently, PFAS concentrations per quantile were linked to an increase in FT3\/FT4 (\u03b2 = 0.004, P = .002) and SPINA-GD (\u03b2 = 0.392, P = .008) in QGC models, with PFOA having the highest weight in all models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This study revealed that PFAS exposures may affect peripheral thyroid hormone sensitivity instead of central among US general adults, enhancing our understanding of the correlation between PFAS exposure and thyroid hormones and providing insights into potential health implications.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgae798","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T12:39:53Z","timestamp":1731933593000},"page":"e2723-e2736","source":"Crossref","is-referenced-by-count":8,"title":["Association Between Per- and Polyfluoroalkyl Substance Exposures and Thyroid Homeostasis Parameters"],"prefix":"10.1210","volume":"110","author":[{"given":"Xinwen","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Endocrinology, The Second Affiliated Hospital of Air Force Medical University , Xi\u2019an 710038, Shaanxi ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Second Affiliated Hospital of Air Force Medical University , Xi\u2019an 710038, Shaanxi ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Second Affiliated Hospital of Air Force Medical University , Xi\u2019an 710038, Shaanxi ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Second Affiliated Hospital of Air Force Medical University , Xi\u2019an 710038, Shaanxi ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Second Affiliated Hospital of Air Force Medical University , Xi\u2019an 710038, Shaanxi ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Second Affiliated Hospital of Air Force Medical University , Xi\u2019an 710038, Shaanxi ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Second Affiliated Hospital of Air Force Medical University , Xi\u2019an 710038, Shaanxi ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Second Affiliated Hospital of Air Force Medical University , Xi\u2019an 710038, Shaanxi ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Shaanxi University of Chinese Medicine , Xianyang 712046, Shaanxi ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0313-1220","authenticated-orcid":false,"given":"Guohong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Second Affiliated Hospital of Air Force Medical University , Xi\u2019an 710038, Shaanxi 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