{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:01:58Z","timestamp":1790218918152,"version":"4.1.0"},"reference-count":44,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Association Fran\u00e7aise des Lipodystrophies"},{"name":"Association Robert-Debr\u00e9 pour la Recherche M\u00e9dicale"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Lipodystrophy syndromes are rare diseases characterized by a generalized or partial lipoatrophic morphotype and metabolic complications. Data on health-related quality of life and impact of genetic lipodystrophy on social or psychological well-being are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Patients with genetic lipodystrophy were recruited throughout the French national reference network for rare diseases of insulin secretion and insulin sensitivity. Patients completed a self-reported questionnaire exploring their physical, psychological, and social well-being and perceived impact of the disease. Descriptive analyses and comparison with general population norms were conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 175 eligible patients, 109 (84% of women) were included, either with familial partial (n = 93) or congenital generalized (n = 16) lipodystrophy. Health-related quality of life based on physical and mental scores was significantly decreased compared to the French general population of similar age and gender (P &amp;lt; .001 for both). Forty-one percent of patients reported moderate or severe depression and 69% dealt with chronic pain. Half of respondents had taken tranquilizers, sleeping pills, or antidepressants over their life. Female participants with genetic lipodystrophy were more frequently unemployed due to health issues as compared to the general population. Social discrimination was highly prevalent (73%), coming, in 34% of cases, from health professionals. More than half of affected women reported a very negative impact of lipodystrophy on body image, significantly associated with depressive symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study highlights the need of psychosocial support in patients with lipodystrophy. An integrated approach and evaluation of psychological and physical symptoms by physicians should be made available to organize specialized care and set up specific therapeutic educational programs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgae837","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T23:22:57Z","timestamp":1733268177000},"page":"e2532-e2543","source":"Crossref","is-referenced-by-count":4,"title":["Health-related Quality of Life, Social, and Psychological Well-Being of 109 Adult Patients With Genetic Lipodystrophy"],"prefix":"10.1210","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7360-4209","authenticated-orcid":false,"given":"H\u00e9l\u00e9na","family":"Mosbah","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, ECEVE UMR 1123, INSERM , 75014 Paris ,","place":["France"]},{"name":"Service Endocrinologie, Diab\u00e9tologie, Nutrition, CHU La Mil\u00e9trie , 86000 Poitiers ,","place":["France"]},{"name":"H\u00f4pital Saint-Antoine, Centre de R\u00e9f\u00e9rence des Maladies Rares de l\u2019Insulino-S\u00e9cr\u00e9tion et de l\u2019Insulino-Sensibilit\u00e9 (PRISIS), Service d\u2019Endocrinologie, Assistance Publique-H\u00f4pitaux de Paris (AP-HP) , 75012 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8342-1596","authenticated-orcid":false,"given":"Camille","family":"Vatier","sequence":"additional","affiliation":[{"name":"H\u00f4pital Saint-Antoine, Centre de R\u00e9f\u00e9rence des Maladies Rares de l\u2019Insulino-S\u00e9cr\u00e9tion et de l\u2019Insulino-Sensibilit\u00e9 (PRISIS), Service d\u2019Endocrinologie, Assistance Publique-H\u00f4pitaux de Paris (AP-HP) , 75012 Paris ,","place":["France"]},{"name":"Sorbonne Universit\u00e9, Inserm U938, Centre de Recherche Saint-Antoine et Institut de Cardio-M\u00e9tabolisme et Nutrition (ICAN) , 75012 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Andriss","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'Epid\u00e9miologie Clinique, APHP, H\u00f4pital Universitaire Robert Debr\u00e9 , 75019 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e8s","family":"Belalem","sequence":"additional","affiliation":[{"name":"H\u00f4pital Saint-Antoine, Centre de R\u00e9f\u00e9rence des Maladies Rares de l\u2019Insulino-S\u00e9cr\u00e9tion et de l\u2019Insulino-Sensibilit\u00e9 (PRISIS), Service d\u2019Endocrinologie, Assistance Publique-H\u00f4pitaux de Paris (AP-HP) , 75012 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4320-2601","authenticated-orcid":false,"given":"Brigitte","family":"Delemer","sequence":"additional","affiliation":[{"name":"Service d'endocrinologie diab\u00e8te nutrition, CHU de Reims, H\u00f4pital Robert-Debr\u00e9 , 51100 Reims ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Janmaat","sequence":"additional","affiliation":[{"name":"H\u00f4pital Saint-Antoine, Centre de R\u00e9f\u00e9rence des Maladies Rares de l\u2019Insulino-S\u00e9cr\u00e9tion et de l\u2019Insulino-Sensibilit\u00e9 (PRISIS), Service d\u2019Endocrinologie, Assistance Publique-H\u00f4pitaux de Paris (AP-HP) , 75012 Paris ,","place":["France"]},{"name":"Sorbonne Universit\u00e9, Inserm U938, Centre de Recherche Saint-Antoine et Institut de Cardio-M\u00e9tabolisme et Nutrition (ICAN) , 75012 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Deborah","family":"Bouhnik","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, INSERM, IRD, ISSPAM, SESSTIM, Sciences Economiques & Sociales de la Sant\u00e9 & Traitement de l\u2019Information M\u00e9dicale, Equipe CALIPSO , 13284 Marseille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauriane","family":"Le Collen","sequence":"additional","affiliation":[{"name":"Univ. 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