{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:23:09Z","timestamp":1792012989196,"version":"4.4.0"},"reference-count":49,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Shenzhen Second People's Hospital Clinical Research Fund of Guangdong Province High-level Hospital Construction Project","award":["20213357018"],"award-info":[{"award-number":["20213357018"]}]},{"name":"Shenzhen Key Medical Discipline Construction Fund","award":["SZXK009"],"award-info":[{"award-number":["SZXK009"]}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["SZSM202211013"],"award-info":[{"award-number":["SZSM202211013"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"publisher","award":["2021YFC2500200"],"award-info":[{"award-number":["2021YFC2500200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangdong Key Program of Precision Medicine","award":["2022"],"award-info":[{"award-number":["2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Thyroid dysfunction is prevalent in chronic kidney disease (CKD) patients and significantly impacts renal outcomes and mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This study investigated the associations between thyroid function and clinical outcomes, and also the therapeutic effects of thyroid hormone replacement therapy (THRT) in CKD patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a retrospective cohort study using data from the China Renal Data System. The primary endpoints were composite renal failure and all-cause mortality. The secondary endpoint was the impact of THRT on renal outcomes. Associations were analyzed using multivariable Cox proportional hazards regression models and Kaplan-Meier survival analyses, with adjustment for relevant clinical and demographic covariates.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 30 804 CKD patients enrolled, 26 673 (86.6%) had normal thyroid function, 2291 (7.4%) had hypothyroidism, and 1840 (6.0%) had hyperthyroidism. Hypothyroidism independently predicted increased risk of renal failure (adjusted HR = 1.29; 95% CI, 1.15-1.45; P &amp;lt; .001). Both hypothyroidism (adjusted HR = 1.24; 95% CI, 1.11-1.39; P &amp;lt; .001) and hyperthyroidism (adjusted HR = 1.20; 95% CI, 1.07-1.33; P &amp;lt; .01) were associated with increased all-cause mortality. Notably, THRT was associated with significantly reduced risk of renal failure (adjusted HR = 0.65; 95% CI, 0.52-0.82; P &amp;lt; .001) in hypothyroid patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This large-scale cohort study demonstrates that hypothyroidism accelerates CKD progression, while both hypo- and hyperthyroidism increase mortality risk in CKD patients. THRT appears to attenuate the adverse effects of hypothyroidism on renal function. Regular thyroid function monitoring and appropriate THRT should be considered in CKD management.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgae841","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T19:54:04Z","timestamp":1733860444000},"page":"e2446-e2455","source":"Crossref","is-referenced-by-count":12,"title":["Chronic Kidney Disease and Thyroid Hormones"],"prefix":"10.1210","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2677-0698","authenticated-orcid":false,"given":"Yuan","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Nephrology, The Second People's Hospital of Shenzhen, The First Affiliated Hospital of Shenzhen University , Shenzhen 518000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haofei","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Second People's Hospital of Shenzhen, The First Affiliated Hospital of Shenzhen University , Shenzhen 518000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9793-3902","authenticated-orcid":false,"given":"Wangyang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Second People's Hospital of Shenzhen, The First Affiliated Hospital of Shenzhen University , Shenzhen 518000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8267-7909","authenticated-orcid":false,"given":"Sheng","family":"Nie","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Nanfang Hospital, Southern Medical University , Guangzhou 510515 ,","place":["China"]},{"name":"National Clinical Research Center for Kidney Disease , Guangzhou 510515 ,","place":["China"]},{"name":"State Key Laboratory of Organ Failure Research , Southern Medical University, Guangzhou 510515 ,","place":["China"]},{"name":"Guangdong Provincial Key Laboratory of Renal Failure Research, Guangdong Provincial Institute of Nephrology , Guangzhou 510515 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Nanfang Hospital, Southern Medical University , Guangzhou 510515 ,","place":["China"]},{"name":"National Clinical Research Center for Kidney Disease , Guangzhou 510515 ,","place":["China"]},{"name":"State Key Laboratory of Organ Failure Research , Southern Medical University, Guangzhou 510515 ,","place":["China"]},{"name":"Guangdong Provincial Key Laboratory of Renal Failure Research, Guangdong Provincial Institute of Nephrology , Guangzhou 510515 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuna","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Second People's Hospital of Shenzhen, The First Affiliated Hospital of Shenzhen University , Shenzhen 518000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Second People's Hospital of Shenzhen, The First Affiliated Hospital of Shenzhen University , Shenzhen 518000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Children's Hospital of Fudan University , Shanghai 201102 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bicheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Nephrology, Zhongda Hospital, Southeast University School of Medicine , Nanjing 210009 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,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zha","sequence":"additional","affiliation":[{"name":"Guizhou Provincial People's Hospital, Guizhou University , Guiyang 550002 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Second Affiliated Hospital of Zhejiang University School of Medicine , Hangzhou 310009 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Xu","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjun","family":"Shi","sequence":"additional","affiliation":[{"name":"Huizhou Municipal Central Hospital, Sun Yat-Sen University , 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