{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T14:17:27Z","timestamp":1754144247833,"version":"3.41.2"},"reference-count":22,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T00:00:00Z","timestamp":1733443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100008122","name":"Institute of Information & Communications Technology Planning & Evaluation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008122","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korean government","award":["RS-2022-II220621"],"award-info":[{"award-number":["RS-2022-II220621"]}]},{"name":"Korean government"},{"name":"Korea Health Technology R&D Project"},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Health & Welfare, Republic of Korea","award":["RS-2023-00262087"],"award-info":[{"award-number":["RS-2023-00262087"]}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korean government","award":["2023R1A2C2002783","2021R1A2C2003410"],"award-info":[{"award-number":["2023R1A2C2002783","2021R1A2C2003410"]}]},{"name":"Korea Health Technology R&D Project"},{"name":"Ministry of Health & Welfare, Republic of Korea","award":["HI22C1377"],"award-info":[{"award-number":["HI22C1377"]}]},{"DOI":"10.13039\/100016275","name":"Seoul National University Bundang Hospital","doi-asserted-by":"publisher","award":["02-2023-0038"],"award-info":[{"award-number":["02-2023-0038"]}],"id":[{"id":"10.13039\/100016275","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Fragility fractures in young adults present significant clinical challenges due to the limited evidence on the effectiveness of bisphosphonates in preventing subsequent fractures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To evaluate the effectiveness of bisphosphonate therapy in reducing the fracture risk among premenopausal women with a history of osteoporotic fractures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>A population-based retrospective cohort study was conducted using data from the National Health Insurance Service-National Sample Cohort in South Korea, covering the years 2003 to 2014.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>A nationwide healthcare setting utilizing a representative cohort database.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>Among 2087 premenopausal women with osteoporotic fractures, participants were propensity score-matched based on age and body mass index at a 1:3 ratio, resulting in 132 bisphosphonate users and 396 nonusers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Intervention<\/jats:title>\n                  <jats:p>Bisphosphonate treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures<\/jats:title>\n                  <jats:p>The incidence of osteoporotic fractures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Bisphosphonate users had a significantly lower risk of major osteoporotic fractures [hazard ratio (HR) 0.618, 95% confidence interval (CI) 0.396-0.963] compared to nonusers. Ibandronate users showed significant reductions in both major osteoporotic (HR 0.376, 95% CI 0.164-0.861) and nonvertebral fractures (HR 0.214, 95% CI 0.052-0.877). Also, longer duration of bisphosphonate use (\u2265180 days) was associated with a significantly lower risk of major osteoporotic and nonvertebral fractures (HR 0.528, 95% CI 0.300-0.929; HR 0.409, 95% CI 0.187-0.895, respectively).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Bisphosphonate therapy significantly reduces fracture risk in premenopausal women with previous osteoporotic fractures, especially at higher cumulative doses. These findings support considering bisphosphonates as a treatment option in premenopausal women at high risk of fractures.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgae850","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T17:36:39Z","timestamp":1733852199000},"page":"e2523-e2531","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of Bisphosphonates in Young Adults With Fragility Fractures: Representative Population-based Cohort Study"],"prefix":"10.1210","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8791-0909","authenticated-orcid":false,"given":"Sung Hye","family":"Kong","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Bundang Hospital , Seongnam, 13620 ,","place":["Republic of Korea"]},{"name":"Department of Internal Medicine, Seoul National University College of Medicine , Seoul, 03080 ,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju-young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Applied Statistics, Yonsei University , Seoul, 03722 ,","place":["Republic of Korea"]},{"name":"Department of Statistics and Data Science, Yonsei University , Seoul, 03722 ,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moon-Kyung","family":"Shin","sequence":"additional","affiliation":[{"name":"Medical Research Institute, Ewha Womans University, College of Medicine , Seoul, 07804 ,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo-Jung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Section of Dentistry, Seoul National University Bundang Hospital , Seongnam, 13620 ,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Research Institute for Intractable Osteonecrosis of the Jaw, Ewha Womans University College of Medicine , Seoul 07804 ,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Shin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Hospital , Seoul, 03080 ,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Wan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University College of Medicine , Seoul, 03080 ,","place":["Republic of Korea"]},{"name":"Department of Internal Medicine, Seoul National University Boramae Hospital , Seoul, 13620 ,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan Soo","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University College of Medicine , Seoul, 03080 ,","place":["Republic of Korea"]},{"name":"Department of Internal Medicine, Seoul National University Hospital , Seoul, 03080 ,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9937-762X","authenticated-orcid":false,"given":"Tae-Jin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurology, Seoul Hospital, Ewha Womans University College of Medicine , Seoul 07804 ,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2024,12,6]]},"reference":[{"key":"2025071507132099200_dgae850-B1","doi-asserted-by":"crossref","first-page":"882241","DOI":"10.3389\/fendo.2022.882241","article-title":"The global burden of osteoporosis, low bone mass, and its related fracture in 204 countries and territories, 1990-2019","volume":"13","author":"Shen","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"12","key":"2025071507132099200_dgae850-B2","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1007\/s00198-012-2030-x","article-title":"Osteoporosis in young adults: pathophysiology, diagnosis, and management","volume":"23","author":"Ferrari","year":"2012","journal-title":"Osteoporos Int"},{"issue":"3","key":"2025071507132099200_dgae850-B3","doi-asserted-by":"crossref","first-page":"101776","DOI":"10.1016\/j.berh.2022.101776","article-title":"Osteoporosis in children and young adults","volume":"36","author":"Sakka","year":"2022","journal-title":"Best Pract Res Clin Rheumatol"},{"issue":"1","key":"2025071507132099200_dgae850-B4","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/jbmr.2708","article-title":"Managing osteoporosis in patients on long-term bisphosphonate treatment: report of a task force of the American society for bone and mineral research","volume":"31","author":"Adler","year":"2016","journal-title":"J Bone Miner Res"},{"issue":"4","key":"2025071507132099200_dgae850-B5","first-page":"CD005324","article-title":"Bisphosphonate therapy for children and adolescents with secondary osteoporosis","volume":"2007","author":"Ward","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"issue":"12","key":"2025071507132099200_dgae850-B6","first-page":"e5222","article-title":"Zoledronic acid vs placebo in pediatric glucocorticoid-induced osteoporosis: a randomized, double-blind, phase 3 trial","volume":"106","author":"Ward","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2025071507132099200_dgae850-B7","first-page":"e15","article-title":"Cohort profile: the national health insurance service-national sample cohort (NHIS-NSC), South Korea","volume":"46","author":"Lee","year":"2017","journal-title":"Int J Epidemiol"},{"issue":"4","key":"2025071507132099200_dgae850-B8","first-page":"188","article-title":"Charlson comorbidity Index: iCD-9 update and ICD-10 translation","volume":"12","author":"Glasheen","year":"2019","journal-title":"Am Health Drug Benefits"},{"author":"Kong","key":"2025071507132099200_dgae850-B9","article-title":"Online Supplementary material"},{"issue":"10","key":"2025071507132099200_dgae850-B10","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1038\/s41591-019-0597-x","article-title":"Avoidable flaws in observational analyses: an application to statins and cancer","volume":"25","author":"Dickerman","year":"2019","journal-title":"Nat Med"},{"issue":"19","key":"2025071507132099200_dgae850-B11","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1056\/NEJM200105103441904","article-title":"Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis","volume":"344","author":"Neer","year":"2001","journal-title":"N Engl J Med"},{"issue":"19","key":"2025071507132099200_dgae850-B12","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1002\/(SICI)1097-0258(19981015)17:19<2265::AID-SIM918>3.0.CO;2-B","article-title":"Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group","volume":"17","author":"D'Agostino","year":"1998","journal-title":"Stat Med"},{"issue":"3","key":"2025071507132099200_dgae850-B13","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/biomet\/81.3.515","article-title":"Proportional hazards tests and diagnostics based on weighted residuals","volume":"81","author":"Grambsch","year":"1994","journal-title":"Biometrika"},{"issue":"1","key":"2025071507132099200_dgae850-B14","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/13697137.2021.1926974","article-title":"Premenopausal osteoporosis","volume":"25","author":"Conradie","year":"2022","journal-title":"Climacteric"},{"issue":"5","key":"2025071507132099200_dgae850-B15","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1159\/000365889","article-title":"The use of bisphosphonates in pediatrics","volume":"82","author":"Baroncelli","year":"2014","journal-title":"Horm Res Paediatr"},{"issue":"10","key":"2025071507132099200_dgae850-B16","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.eprac.2021.06.007","article-title":"Effect of bisphosphonates on fracture incidence in young adults with low bone density","volume":"27","author":"Choudhary","year":"2021","journal-title":"Endocr Pract"},{"key":"2025071507132099200_dgae850-B17","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.bone.2013.11.016","article-title":"Differing effects of denosumab and alendronate on cortical and trabecular bone","volume":"59","author":"Zebaze","year":"2014","journal-title":"Bone"},{"issue":"9","key":"2025071507132099200_dgae850-B18","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1177\/0091270004267594","article-title":"Ibandronate: a clinical pharmacological and pharmacokinetic update","volume":"44","author":"Barrett","year":"2004","journal-title":"J Clin Pharmacol"},{"issue":"1","key":"2025071507132099200_dgae850-B19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1359\/jbmr.0301202","article-title":"Oral daily ibandronate prevents bone loss in early postmenopausal women without osteoporosis","volume":"19","author":"McClung","year":"2004","journal-title":"J Bone Miner Res"},{"issue":"5","key":"2025071507132099200_dgae850-B20","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S2213-2600(13)70064-X","article-title":"Treatment of low bone density in young people with cystic fibrosis: a multicentre, prospective, open-label observational study of calcium and calcifediol followed by a randomised placebo-controlled trial of alendronate","volume":"1","author":"Bianchi","year":"2013","journal-title":"Lancet Respir Med"},{"issue":"1","key":"2025071507132099200_dgae850-B21","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s001980050010","article-title":"Randomized trial of the effects of risedronate on vertebral fractures in women with established postmenopausal osteoporosis. Vertebral Efficacy with Risedronate Therapy (VERT) Study Group","volume":"11","author":"Reginster","year":"2000","journal-title":"Osteoporos Int"},{"issue":"5","key":"2025071507132099200_dgae850-B22","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.ejca.2010.11.024","article-title":"Zoledronic acid preserves bone mineral density in premenopausal women who develop ovarian failure due to adjuvant chemotherapy: final results from CALGB trial 79809","volume":"47","author":"Shapiro","year":"2011","journal-title":"Eur J Cancer"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgae850\/61201749\/dgae850.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/110\/8\/e2523\/61201749\/dgae850.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/110\/8\/e2523\/61201749\/dgae850.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T11:14:14Z","timestamp":1752578054000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/110\/8\/e2523\/7918368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,6]]},"references-count":22,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,12,6]]},"published-print":{"date-parts":[[2025,7,15]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgae850","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"type":"print","value":"0021-972X"},{"type":"electronic","value":"1945-7197"}],"subject":[],"published-other":{"date-parts":[[2025,8]]},"published":{"date-parts":[[2024,12,6]]}}}