{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:14:34Z","timestamp":1785431674208,"version":"3.56.0"},"reference-count":34,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T00:00:00Z","timestamp":1738627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Intraindividual body-weight variability or cycling is associated with increased risk of chronic kidney disease (CKD) in the general population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We conducted a retrospective analysis of data from the Diabetes Control and Complications Trial (DCCT)\/Epidemiology of Diabetes Interventions and Complications (EDIC) studies to assess association between body-weight cycling and the risk of renal events in type 1 diabetes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Four indices of intraindividual body-weight variability were calculated for 1432 participants of DCCT\/EDIC taking into account body-weight measurements during the DCCT follow-up (6 \u00b1 2 years). Variability independent of the mean (VIM) was the main index. Six criteria of progression to CKD were studied during DCCT\/EDIC follow-up (21 \u00b1 4 years). Hazard ratio (HR) with 95% confidence interval (CI) were computed in Cox analyses for 1 SD of the indices expressed as Z-score.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A high VIM was significantly associated with the incidence of a 40% decline in eGFR from baseline values (HR, 1.25; 95% CI, 1.09-1.41; P = .001), doubling of baseline serum creatinine (HR, 1.34; 95% CI, 1.13-1.57; P = .001), CKD stage 3 (HR, 1.36; 95% CI, 1.12-1.63; P = .002), and with a decline in eGFR &amp;gt; 3\u2005mL\/min\/m2 per year (all analyses adjusted for CKD risk factors at baseline and follow-up, and use of nephroprotective drugs). VIM was also associated with the incidence of moderately and severely increased albuminuria, but associations did not remain significant following adjustment for follow-up covariates. Similar results were observed for the other indices of body-weight cycling.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Body-weight cycling is significantly associated with an increased risk of kidney events in people with type 1 diabetes, regardless of body mass index and traditional risk factors.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgae852","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T09:01:36Z","timestamp":1738659696000},"page":"e3334-e3342","source":"Crossref","is-referenced-by-count":3,"title":["Body-weight Cycling and Risk of Diabetic Kidney Disease in People With Type 1 Diabetes in the DCCT\/EDIC Population"],"prefix":"10.1210","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1388-2482","authenticated-orcid":false,"given":"Marion","family":"Camoin","sequence":"first","affiliation":[{"name":"Department of Diabetology and Endocrinology, Assistance Publique\u2014H\u00f4pitaux de Paris, Bichat Hospital , Paris 75018 ,","place":["France"]},{"name":"Department of Endocrinology, Diabetes and Nutrition, Bordeaux University Hospital (H\u00f4pital Haut-L\u00e9v\u00eaque) , Pessac 33600 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6139-1197","authenticated-orcid":false,"given":"Kamel","family":"Mohammedi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Nutrition, Bordeaux University Hospital (H\u00f4pital Haut-L\u00e9v\u00eaque) , Pessac 33600 ,","place":["France"]},{"name":"Inserm U1034, Biologie des Maladies Cardiovasculaires , Pessac 33600 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