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Several micro (mi)RNAs have been shown to promote TED progression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This study aims to explore the regulatory effects of miRNAs on CD34+ OFs and to find potential therapeutic targets.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this case-control study, orbital connective tissues (OCTs) and OFs were obtained from 25 TED patients and 24 healthy donors. MiRNA-seq was performed to examine differential expression of miRNAs in OCTs, and miR-182-5p was selected for subsequent experiments. MiR-182-5p was detected both in CD34+ and CD34\u2212 OFs. The upstream regulators of miR-182-5p were studied. Downstream targets of miR-182-5p were analyzed. The functionality of miR-182-5p in CD34+ OFs was evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>MiR-182-5p was highly expressed in TED OCTs and their derived CD34+ OFs. TED OCTs displayed increased expression of interleukin (IL)-6, IL-17A, CD34, and phosphorylated STAT3 at Ser727 and Tyr705. Activation of IL-6\/STAT3 signaling promoted the expression of miR-182-5p in CD34+ OFs. MiR-182-5p enhanced wound repair ability, proliferation, and RANTES expression while inhibiting apoptosis in CD34+ OFs. CD34+ OFs transfected with miR-182-5p were susceptible to TGF-\u03b2-initiated myofibroblast differentiation. Luciferase reporter and pull-down assays revealed Smad7 as the downstream target of miR-182-5p, which modulated the proliferation, migration, fibrosis, and apoptosis of CD34+ OFs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The IL-6\/STAT3\/miR-182-5p pathway led to activation of CD34+ OFs. MiR-182-5p promoted the proliferation, migration, fibrosis, and anti-apoptosis of CD34+ OFs via targeting Smad7. Our findings suggest that miR-182-5p may potentially serve as a therapeutic target for TED.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgae876","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T12:44:33Z","timestamp":1734525873000},"page":"2631-2644","source":"Crossref","is-referenced-by-count":9,"title":["CD34+ Orbital Fibroblasts Contribute to the Pathogenesis of Thyroid Eye Disease via miR-182-5p"],"prefix":"10.1210","volume":"110","author":[{"given":"Baiguang","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, and Center for Basic Medical Research and Innovation in Visual System Diseases of Ministry of Education, Shanghai Jiao Tong University School of Medicine , Shanghai 200001 ,","place":["China"]},{"name":"Center for Immune-Related Diseases at Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine , Shanghai 200023 ,","place":["China"]},{"name":"Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine , Shanghai 200023 ,","place":["China"]},{"name":"Chinese Consortium for Thyroid Eye Disease (CCTED) , Shanghai 200001 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, and Center for Basic Medical Research and Innovation in Visual System Diseases of Ministry of Education, Shanghai Jiao Tong University School of Medicine , Shanghai 200001 ,","place":["China"]},{"name":"Center for Immune-Related Diseases at Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine , Shanghai 200023 ,","place":["China"]},{"name":"Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine , Shanghai 200023 ,","place":["China"]},{"name":"Chinese Consortium for Thyroid Eye Disease (CCTED) , Shanghai 200001 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, and Center for Basic Medical Research and Innovation in Visual System Diseases of Ministry of Education, Shanghai Jiao Tong University School of Medicine , Shanghai 200001 ,","place":["China"]},{"name":"Center for Immune-Related Diseases at Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine , Shanghai 200023 ,","place":["China"]},{"name":"Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine , Shanghai 200023 ,","place":["China"]},{"name":"Chinese Consortium for Thyroid Eye Disease (CCTED) , Shanghai 200001 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, and Center for Basic Medical Research and Innovation in Visual System Diseases of Ministry of Education, Shanghai Jiao Tong University School of Medicine , Shanghai 200001 ,","place":["China"]},{"name":"Center for Immune-Related Diseases at Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine , Shanghai 200023 ,","place":["China"]},{"name":"Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine , Shanghai 200023 ,","place":["China"]},{"name":"Chinese Consortium for Thyroid Eye Disease (CCTED) , Shanghai 200001 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