{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T10:26:30Z","timestamp":1770891990098,"version":"3.50.1"},"reference-count":54,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473646"],"award-info":[{"award-number":["82473646"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Sichuan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024NSFSC0578"],"award-info":[{"award-number":["2024NSFSC0578"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["YJ202346"],"award-info":[{"award-number":["YJ202346"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"publisher","award":["2022YFC2702905"],"award-info":[{"award-number":["2022YFC2702905"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Renal function may play a crucial role in the development of gestational diabetes mellitus (GDM). However, prospective studies on this topic are scarce and the mechanisms remain unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This work aimed to assess the associations of early-pregnancy renal function with GDM and the mediating role of carnitine metabolites.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The study was based on the Tongji-Huaxi-Shuangliu Birth Cohort. Renal function was routinely assessed before 15 gestational weeks. Plasma carnitine metabolites in early pregnancy were quantified using ultrahigh-performance liquid chromatography\u2013tandem mass spectrometry. GDM was diagnosed at 24 to 28 gestational weeks by a 2-hour oral glucose tolerance test. Multivariable logistic regression was used to examine the associations of renal function indicators with GDM. Mediation analyses were applied to assess the mediating effects of carnitines.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The mean age of 6770 participants was 26.6 \u00b1 3.7 years. Serum uric acid, uric acid to creatinine ratio, and estimated glomerular filtration rate (eGFR) were positively associated with GDM, and the odds ratios (95% CIs) were 1.67 (95% CI, 1.25-2.23), 1.94 (1.47-2.57), and 1.53 (1.17-2.01) for the extreme-quartile comparison. Increased creatinine, cystatin C, and creatinine to weight ratio were associated with lower GDM risk, with ORs of 0.62 (0.47-0.82), 0.72 (0.52-0.99), and 0.69 (0.53-0.91) for the extreme-quartile comparison. Serum creatinine-, creatinine to weight ratio-, and eGFR-related carnitine scores played positive mediating roles, and the mediation proportions were 43.1%, 81.9%, and 56.7%, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Renal function should be monitored for GDM, and the potential roles of carnitine metabolites require further evaluation and validation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgae881","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T03:35:21Z","timestamp":1734492921000},"page":"e3052-e3062","source":"Crossref","is-referenced-by-count":3,"title":["Renal Function and Risk of Gestational Diabetes Mellitus: The Potential Mediating Role of Carnitine Metabolites"],"prefix":"10.1210","volume":"110","author":[{"given":"Xue","family":"Yang","sequence":"first","affiliation":[{"name":"Section of Epidemiology and Population Health & Department of Gynecology and Obstetrics, Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children & Children's Medicine Key Laboratory of Sichuan Province, West China Second University Hospital, Sichuan University , Chengdu, Sichuan 610041 ,","place":["China"]},{"name":"MED-X Institute, Center for Immunological and Metabolic Diseases, the First Affiliated Hospital of Xi\u2019an Jiaotong University , Xi\u2019an, Shaanxi 710061 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jieru","family":"Peng","sequence":"additional","affiliation":[{"name":"Section of Epidemiology and Population Health & Department of Gynecology and Obstetrics, Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children & Children's Medicine Key Laboratory of Sichuan Province, West China Second University Hospital, Sichuan University , Chengdu, Sichuan 610041 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengjiang","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Environment, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University , Guangzhou, Guangdong 510632 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5718-9922","authenticated-orcid":false,"given":"Ping","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, Hubei 430030 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health, Albert Einstein College of Medicine , Bronx, NY 10461 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Xu","sequence":"additional","affiliation":[{"name":"Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University , Hangzhou, Zhejiang 310003 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuwei","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, Hubei 430030 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaying","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Science and Education & Shuangliu Institute of Women's and Children's Health, Shuangliu Maternal and Child Health Hospital , Chengdu, Sichuan 610200 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Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Lab of Environment and Health, and State Key Laboratory of Environment Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, Hubei 430030 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunxia","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University , Chengdu, Sichuan 610041 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5563-0091","authenticated-orcid":false,"given":"Da","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Environment, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University , Guangzhou, Guangdong 510632 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