{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T01:29:51Z","timestamp":1789003791959,"version":"build-2803163510"},"reference-count":35,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U21A20355"],"award-info":[{"award-number":["U21A20355"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Joint Medical Research Project of Chongqing Science and Technology Commission & Chongqing Health and Family Planning Commission","award":["2022ZDXM003"],"award-info":[{"award-number":["2022ZDXM003"]}]},{"name":"National Key Research & Development Plan of China, Major Project of Prevention and Treatment for Common Diseases","award":["2021YFC2501600"],"award-info":[{"award-number":["2021YFC2501600"]}]},{"name":"National Key Research & Development Plan of China, Major Project of Prevention and Treatment for Common Diseases","award":["2021YFC2501603"],"award-info":[{"award-number":["2021YFC2501603"]}]},{"name":"The National Key Research and Development Project","award":["2022YFC2505300"],"award-info":[{"award-number":["2022YFC2505300"]}]},{"name":"The National Key Research and Development Project","award":["2022YFC2505301"],"award-info":[{"award-number":["2022YFC2505301"]}]},{"name":"The National Key Research and Development Project","award":["2022YFC2505302"],"award-info":[{"award-number":["2022YFC2505302"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Adrenal venous sampling (AVS) is recommended for subtyping primary aldosteronism (PA); however, it is unreliable when apparent bilateral aldosterone suppression (ABAS) occurs, defined as aldosterone\/cortisol ratio in the adrenal vein being bilaterally lower than that in the inferior vena cava. The value of liquid chromatography\u2013tandem mass spectrometry (LC-MS\/MS) in PA subtyping when ABAS occurs is unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This work aimed to determine whether LC-MS\/MS can reduce the occurrence of ABAS and misdiagnosis of PA subtyping.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Aldosterone and cortisol in AVS samples from 219 patients with PA were measured by LC-MS\/MS and immunoassay (IA). Then ABAS occurrence and misdiagnosis rate of PA subtyping were calculated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 219 patients with PA, 111 and 60 received nonadrenocorticotropin (non-ACTH) and ACTH-stimulated AVS, respectively, and 48 received both. In unstimulated AVS, LC-MS\/MS reduced the ABAS occurrence compared to IA (10.7% [17\/159] vs 3.1% [5\/159]). Among 159 patients with unstimulated AVS, there were 77 patients who had final subtyping diagnosis based on postoperative outcomes. The misdiagnosis rate of IA and LC-MS\/MS was 10.4% (8\/77) and 9.1% (7\/77), respectively. However, misdiagnosis was more common in patients with ABAS than in those without ABAS. For IA, 5 out of 6 ABAS patients were misdiagnosed, while 3\/71 non-ABAS patients were misdiagnosed. For LC MS\/MS, only one ABAS patient had follow-up outcome and he was misdiagnosed, while 6 of 76 non-ABAS patients were misdiagnosed. Similar results were found in ACTH-stimulated AVS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>LC-MS\/MS measurement of aldosterone and cortisol is a new resolution when ABAS occurs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgae891","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T14:37:53Z","timestamp":1734964673000},"page":"e3011-e3020","source":"Crossref","is-referenced-by-count":7,"title":["The Value of LC-MS\/MS in Apparent Bilateral Aldosterone Suppression in Adrenal Venous Sampling for Primary Aldosteronism"],"prefix":"10.1210","volume":"110","author":[{"given":"Wei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University , Chongqing 400016 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qixin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University , Chongqing 400016 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University , Chongqing 400016 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"He","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University , Chongqing 400016 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University , Chongqing 400016 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2925-0583","authenticated-orcid":false,"given":"Jinbo","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University , Chongqing 400016 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University , Chongqing 400016 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University , Chongqing 400016 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