{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T18:16:40Z","timestamp":1782325000499,"version":"3.54.5"},"reference-count":38,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T00:00:00Z","timestamp":1735084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Korean ARPA-H Project through the Korea Health Industry Development Institute"},{"name":"Ministry of Health & Welfare, Republic of Korea","award":["RS-2024-00507256)"],"award-info":[{"award-number":["RS-2024-00507256)"]}]},{"name":"the Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea","award":["2024IL0013"],"award-info":[{"award-number":["2024IL0013"]}]},{"DOI":"10.13039\/501100003725","name":"the National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"South Korean government","award":["2021R1C1C2006842"],"award-info":[{"award-number":["2021R1C1C2006842"]}]},{"name":"Hallym University Medical Center Research Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,7]]},"abstract":"Abstract<\/jats:title>\n \n Context<\/jats:title>\n Experimental evidence indicates that resistin, an adipokine, negatively impacts muscle metabolism by hindering myogenesis.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To explore resistin's potential as a biomarker of muscle health in humans by examining the relationship between circulating resistin levels and sarcopenia in older adults.<\/jats:p>\n <\/jats:sec>\n \n Design and Setting<\/jats:title>\n A case-control study conducted in a geriatric clinical unit.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n The study included 247 individuals aged 65 and older who underwent comprehensive geriatric evaluations.<\/jats:p>\n <\/jats:sec>\n \n Main Outcome Measures<\/jats:title>\n Sarcopenia was defined based on Asian-specific thresholds, with serum resistin concentrations measured using an ELISA.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n After adjusting for sex, age, fat mass, smoking, osteoarthritis, and diabetes, participants with sarcopenia, low muscle mass, and weak muscle strength exhibited at least 27.0% higher circulating resistin concentrations than controls (P = .002-.003). Elevated serum resistin levels were inversely associated with skeletal muscle mass, gait speed, and the short physical performance battery score and positively associated with the time to complete 5 chair stands (P = .019-.048). Higher serum resistin levels were linked to an increased risk of sarcopenia, low muscle mass, and weak muscle strength (all P = .005). Finally, participants in the highest resistin quartile had at least 3 times higher odds of having adverse muscle outcomes compared to those in the lowest quartile (P = .007-.029).<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This study set out to establish a link between blood resistin levels and sarcopenia, suggesting that circulating resistin may serve as a potential biomarker reflecting poor muscle health in humans.<\/jats:p>\n <\/jats:sec>","DOI":"10.1210\/clinem\/dgae894","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T19:01:18Z","timestamp":1735066878000},"page":"e2994-e3001","source":"Crossref","is-referenced-by-count":10,"title":["Higher Circulating Resistin Levels Linked to Increased Sarcopenia Risk in Older Adults"],"prefix":"10.1210","volume":"110","author":[{"given":"Mi Kyung","family":"Kwak","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital , Gyeonggi-do 18450 ,","place":["South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Yeon","family":"Baek","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine , Seoul 05505 ,","place":["South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Jeong","family":"Park","sequence":"additional","affiliation":[{"name":"Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine , Seoul 05505 ,","place":["South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2583-3354","authenticated-orcid":false,"given":"Hee-Won","family":"Jung","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine , Seoul 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