{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:47:01Z","timestamp":1787021221917,"version":"build-2736575974"},"reference-count":38,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2019\/15873-6"],"award-info":[{"award-number":["2019\/15873-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"FAPESP fellowship","award":["2021\/09879-1"],"award-info":[{"award-number":["2021\/09879-1"]}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["304091\/2021-9"],"award-info":[{"award-number":["304091\/2021-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>The role of plasma metanephrine in adrenal venous sampling (AVS) for assessing lateralization in primary aldosteronism (PA) requires further clarification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the performance of plasma metanephrine in AVS for determining aldosterone lateralization in PA, with or without mild autonomous cortisol secretion (MACS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sequential AVS under cosyntropin stimulation was conducted in 58 consecutive patients with PA and indication for AVS. The selectivity index (SI) was assessed using plasma metanephrine (SIMN) and cortisol (SIC). The lateralization index (LI) for aldosterone was calculated using metanephrine (LIA\/MN) and cortisol (LIA\/C).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Right SIMN was significantly higher than left SIMN (127.91\u2005nmol\/L [78.12, 239.12] vs 46.16\u2005nmol\/L [26, 73.87]; P &amp;lt; .001). SIMN and SIC were strongly correlated in both the right adrenal vein (r = 0.518, P &amp;lt; .001) and the left adrenal vein (r = 0.435, P &amp;lt; .001). A SIMN &amp;gt; 6.45 demonstrated a sensitivity and specificity of 100%, outperforming the cut-off of 12 for identifying successful catheterization. Six cases with SIMN &amp;gt; 12 and SIC between 3 and 5 indicated that a SIC &amp;gt; 3 is sufficient for 4-confirming successful cannulation. LIA\/MN and LIA\/C were significantly correlated (r = 0.752, P &amp;lt; .001), with PA lateralization concordant in 93.1% of cases. Two discordant cases (unilateral PA by cortisol, bilateral by metanephrine) exhibited nonclassical histology, which is associated with a higher risk of PA recurrence. MACS was identified in 15 out of 58 patients (25.86%) and generally did not influence AVS lateralization, except when aldosterone and cortisol were secreted by different adrenal lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Metanephrine was superior to cortisol after cosyntropin for assessing selectivity and equivalent to cortisol for lateralization. Moreover, MACS did not impact lateralization in AVS under cosyntropin in most cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgae896","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T23:24:11Z","timestamp":1735082651000},"page":"e2985-e2993","source":"Crossref","is-referenced-by-count":8,"title":["Adrenal Venous Sampling Using Metanephrine in Primary Aldosteronism With or Without Cortisol Cosecretion"],"prefix":"10.1210","volume":"110","author":[{"given":"Eduardo Z","family":"Kawahara","sequence":"first","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Endocrinologia Molecular e Celular LIM25, Divis\u00e3o de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo 01246-903 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Okubo","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Endocrinologia Molecular e Celular LIM25, Divis\u00e3o de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo 01246-903 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline C B S","family":"Cavalcante","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Radiologia Intervencionista, Instituto de Radiologia InRAD, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo 05403-000 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna","family":"Pilan","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Radiologia Intervencionista, Instituto de Radiologia InRAD, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo 05403-000 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Frudit","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Endocrinologia Molecular e Celular LIM25, Divis\u00e3o de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo 01246-903 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caio A A","family":"Pereira","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Endocrinologia Molecular e Celular LIM25, Divis\u00e3o de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo 01246-903 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Basmage","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Endocrinologia Molecular e Celular LIM25, Divis\u00e3o de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo 01246-903 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline M","family":"Viel","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Endocrinologia Molecular e Celular LIM25, Divis\u00e3o de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo 01246-903 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Alice W","family":"Maciel","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Endocrinologia Molecular e Celular LIM25, Divis\u00e3o de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo 01246-903 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais C","family":"Freitas","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Endocrinologia Molecular e Celular LIM25, Divis\u00e3o de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo 01246-903 ,","place":["Brazil"]},{"name":"Departmento de Medicina Interna, Divis\u00e3o de Endocrinologia, Faculdade de Medicina, Universidade Federal de Goi\u00e1s , Goi\u00e2nia 74605-050 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo F C","family":"Fagundes","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Endocrinologia Molecular e Celular LIM25, Divis\u00e3o de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo 01246-903 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana S","family":"Goldbaum","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Endocrinologia Molecular e Celular LIM25, Divis\u00e3o de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo 01246-903 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana P","family":"Brito","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular LIM\/42 e Laborat\u00f3rio de Sequenciamento em Larga Escala, Divis\u00e3o de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo 01246-903 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalia L","family":"Gomes","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Endocrinologia, Santa Casa de Belo Horizonte , Belo Horizonte 30150-221 ,","place":["Brazil"]},{"name":"Departmento de Medicina Interna, Faculdade de Medicina, Universidade Federal de Minas Gerais , Belo Horizonte 30130-100 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Adelaide A","family":"Pereira","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Endocrinologia Molecular e Celular LIM25, Divis\u00e3o de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo 01246-903 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando M A","family":"Coelho","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Radiologia, Instituto de Radiologia InRAD, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo 05403-000 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe L","family":"Ledesma","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Anatomia Patol\u00f3gica, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo 05403-000 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose L","family":"Chambo","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Urologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo 05403-000 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz A","family":"Bortolotto","sequence":"additional","affiliation":[{"name":"Unidade de Hipertens\u00e3o, Instituto do Cora\u00e7\u00e3o (InCOR), Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo 05403-900 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Pio-Abreu","sequence":"additional","affiliation":[{"name":"Unidade de Hipertens\u00e3o, Divis\u00e3o de Nefrologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo 05403-000 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanio V","family":"Silva","sequence":"additional","affiliation":[{"name":"Unidade de Hipertens\u00e3o, Divis\u00e3o de Nefrologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo 05403-000 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano F","family":"Drager","sequence":"additional","affiliation":[{"name":"Unidade de Hipertens\u00e3o, Instituto do Cora\u00e7\u00e3o (InCOR), Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo 05403-900 ,","place":["Brazil"]},{"name":"Unidade de Hipertens\u00e3o, Divis\u00e3o de Nefrologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo 05403-000 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Candida B V","family":"Fragoso","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular LIM\/42 e Laborat\u00f3rio de Sequenciamento em Larga Escala, Divis\u00e3o de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo 01246-903 ,","place":["Brazil"]},{"name":"Unidade de Oncologia End\u00f3crina, Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo (ICESP), Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo 01246-000 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C","family":"Nahas","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Urologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo 05403-000 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco C","family":"Carnevale","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Radiologia Intervencionista, Instituto de Radiologia InRAD, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo 05403-000 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Claudia","family":"Latronico","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Endocrinologia Molecular e Celular LIM25, Divis\u00e3o de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo 01246-903 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berenice B","family":"Mendonca","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular LIM\/42 e Laborat\u00f3rio de Sequenciamento em Larga Escala, Divis\u00e3o de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo 01246-903 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2957-6148","authenticated-orcid":false,"given":"Madson Q","family":"Almeida","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Endocrinologia Molecular e Celular LIM25, Divis\u00e3o de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo 01246-903 ,","place":["Brazil"]},{"name":"Unidade de Oncologia End\u00f3crina, Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo (ICESP), Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo 01246-000 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2024,12,26]]},"reference":[{"issue":"10304","key":"2026041420192329500_dgae896-B1","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0140-6736(21)01330-1","article-title":"Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants","volume":"398","author":"(NCD-RisC) NRFC","year":"2021","journal-title":"Lancet"},{"issue":"5","key":"2026041420192329500_dgae896-B2","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1210\/jc.2015-4061","article-title":"The management of primary aldosteronism: case detection, diagnosis, and treatment: an endocrine society clinical practice guideline","volume":"101","author":"Funder","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"14","key":"2026041420192329500_dgae896-B3","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/j.jacc.2017.01.052","article-title":"Prevalence and clinical manifestations of primary aldosteronism encountered in primary care practice","volume":"69","author":"Monticone","year":"2017","journal-title":"J Am Coll Cardiol"},{"issue":"11","key":"2026041420192329500_dgae896-B4","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1016\/j.jacc.2006.07.059","article-title":"A prospective study of the prevalence of primary aldosteronism in 1,125 hypertensive patients","volume":"48","author":"Rossi","year":"2006","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"2026041420192329500_dgae896-B5","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S2213-8587(17)30319-4","article-title":"Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta-analysis","volume":"6","author":"Monticone","year":"2018","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"10","key":"2026041420192329500_dgae896-B6","doi-asserted-by":"crossref","first-page":"4695","DOI":"10.1210\/jc.2019-00531","article-title":"KCNJ5 somatic mutation is a predictor of hypertension remission after adrenalectomy for unilateral primary aldosteronism","volume":"104","author":"Vilela","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"2026041420192329500_dgae896-B7","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1210\/jc.2013-4146","article-title":"Accuracy of adrenal imaging and adrenal venous sampling in predicting surgical cure of primary aldosteronism","volume":"99","author":"Lim","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"2026041420192329500_dgae896-B8","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1210\/clinem\/dgae142","article-title":"Contralateral suppression in adrenal venous sampling predicts clinical and biochemical outcome in primary aldosteronism","volume":"109","author":"Okubo","year":"2024","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2026041420192329500_dgae896-B9","doi-asserted-by":"crossref","first-page":"dgz017","DOI":"10.1210\/clinem\/dgz017","article-title":"Subtyping of primary aldosteronism in the AVIS-2 study: assessment of selectivity and lateralization","volume":"105","author":"Rossitto","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"key":"2026041420192329500_dgae896-B10","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1210\/jc.2018-01324","article-title":"Adrenal venous sampling with or without adrenocorticotropic hormone stimulation: a meta-analysis","volume":"104","author":"Laurent","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2026041420192329500_dgae896-B11","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1161\/HYPERTENSIONAHA.113.01601","article-title":"Plasma metanephrine for assessing the selectivity of adrenal venous sampling","volume":"62","author":"Dekkers","year":"2013","journal-title":"Hypertension"},{"issue":"20","key":"2026041420192329500_dgae896-B12","doi-asserted-by":"crossref","first-page":"4755","DOI":"10.3390\/jcm10204755","article-title":"Comparison of cortisol, androstenedione and metanephrines to assess selectivity and lateralization of adrenal vein sampling in primary aldosteronism","volume":"10","author":"Ceolotto","year":"2021","journal-title":"J Clin Med"},{"issue":"3","key":"2026041420192329500_dgae896-B13","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1055\/a-1756-4937","article-title":"Application of metanephrine and normetanephrine in evaluating the selectivity of adrenal vein sampling","volume":"54","author":"Liu","year":"2022","journal-title":"Horm Metab Res"},{"issue":"9","key":"2026041420192329500_dgae896-B14","doi-asserted-by":"crossref","first-page":"e720","DOI":"10.1210\/clinem\/dgad179","article-title":"Prevalence of cortisol cosecretion in patients with primary aldosteronism: role of metanephrine in adrenal vein sampling","volume":"108","author":"Buffolo","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"2026041420192329500_dgae896-B15","doi-asserted-by":"crossref","first-page":"e93136","DOI":"10.1172\/jci.insight.93136","article-title":"Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism","volume":"2","author":"Arlt","year":"2017","journal-title":"JCI Insight"},{"issue":"10","key":"2026041420192329500_dgae896-B16","doi-asserted-by":"crossref","first-page":"e3776","DOI":"10.1210\/clinem\/dgaa519","article-title":"Low-grade cortisol cosecretion has limited impact on ACTH-stimulated AVS parameters in primary aldosteronism","volume":"105","author":"O'Toole","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2026041420192329500_dgae896-B17","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1530\/EJE-21-0541","article-title":"Influence of cortisol cosecretion on non-ACTH-stimulated adrenal venous sampling in primary aldosteronism: a retrospective cohort study","volume":"187","author":"Heinrich","year":"2022","journal-title":"Eur J Endocrinol"},{"issue":"5","key":"2026041420192329500_dgae896-B18","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1210\/clinem\/dgac679","article-title":"Intra-individual variability of Serum aldosterone and implications for primary aldosteronism screening","volume":"108","author":"Maciel","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2026041420192329500_dgae896-B19","first-page":"350","article-title":"Renal function evolution and hypoaldosteronism risk after unilateral adrenalectomy for primary aldosteronism","volume":"56","author":"Queiroz","year":"2023","journal-title":"Horm Metab Res"},{"issue":"5","key":"2026041420192329500_dgae896-B20","doi-asserted-by":"crossref","first-page":"e2027","DOI":"10.1210\/clinem\/dgab924","article-title":"The saline infusion test for primary aldosteronism: implications of immunoassay inaccuracy","volume":"107","author":"Eisenhofer","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2026041420192329500_dgae896-B21","doi-asserted-by":"crossref","first-page":"bvad147","DOI":"10.1210\/jendso\/bvad147","article-title":"Efficacy of oral furosemide test for primary aldosteronism diagnosis","volume":"8","author":"Freitas","year":"2023","journal-title":"J Endocr Soc"},{"issue":"3","key":"2026041420192329500_dgae896-B22","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1590\/2359-3997000000274","article-title":"Diagnosis and management of primary aldosteronism","volume":"61","author":"Vilela","year":"2017","journal-title":"Arch Endocrinol Metab"},{"issue":"11","key":"2026041420192329500_dgae896-B23","doi-asserted-by":"crossref","first-page":"e4340","DOI":"10.1210\/clinem\/dgab482","article-title":"Identification of surgically curable primary aldosteronism by imaging in a large, multiethnic international study","volume":"106","author":"Rossi","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"2026041420192329500_dgae896-B24","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S2213-8587(17)30135-3","article-title":"Outcomes after adrenalectomy for unilateral primary aldosteronism: an international consensus on outcome measures and analysis of remission rates in an international cohort","volume":"5","author":"Williams","year":"2017","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"5","key":"2026041420192329500_dgae896-B25","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1210\/jc.2011-2830","article-title":"The adrenal vein sampling international study (AVIS) for identifying the major subtypes of primary aldosteronism","volume":"97","author":"Rossi","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2026041420192329500_dgae896-B26","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1093\/ejendo\/lvad066","article-title":"European Society of Endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in collaboration with the European network for the study of adrenal tumors","volume":"189","author":"Fassnacht","year":"2023","journal-title":"Eur J Endocrinol"},{"key":"2026041420192329500_dgae896-B27","unstructured":"Kawahara EZ, Okubo J, Cavalcante ACBS, et al \u00a0Adrenal Venous Sampling Using Metanephrine in Primary Aldosteronism With or Without Cortisol Co-Secretion. Mendeley Data. Online supplementary data available at: https:\/\/data.mendeley.com\/datasets\/45pzwvn7p4\/1. doi:10.17632\/45pzwvn7p4.1. Deposited 16 November 2024."},{"issue":"1","key":"2026041420192329500_dgae896-B28","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1210\/clinem\/dgaa484","article-title":"International histopathology consensus for unilateral primary aldosteronism","volume":"106","author":"Williams","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2026041420192329500_dgae896-B29","first-page":"e230300","article-title":"The value of plasma metanephrine measurements during adrenal vein sampling","volume":"13","author":"Carroll","year":"2024","journal-title":"Endocr Connect"},{"key":"2026041420192329500_dgae896-B30","doi-asserted-by":"crossref","first-page":"842968","DOI":"10.3389\/fendo.2022.842968","article-title":"Accurate location of catheter tip with the free-to-total metanephrine ratio during adrenal vein sampling","volume":"13","author":"Christou","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"3","key":"2026041420192329500_dgae896-B31","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1161\/HYPERTENSIONAHA.123.21910","article-title":"Multifocal, asymmetric bilateral primary aldosteronism cannot be excluded by strong adrenal vein sampling lateralization: an international retrospective cohort study","volume":"81","author":"Turcu","year":"2024","journal-title":"Hypertension"},{"issue":"4","key":"2026041420192329500_dgae896-B32","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1161\/HYPERTENSIONAHA.123.22281","article-title":"Unilateral primary aldosteronism: long-term disease recurrence after adrenalectomy","volume":"81","author":"Tetti","year":"2024","journal-title":"Hypertension"},{"issue":"12","key":"2026041420192329500_dgae896-B33","doi-asserted-by":"crossref","first-page":"e230121","DOI":"10.1530\/EC-23-0121","article-title":"Influence of autonomous cortisol secretion in patients with primary aldosteronism: subtype analysis and postoperative outcome","volume":"12","author":"Hung","year":"2023","journal-title":"Endocr Connect"},{"issue":"8","key":"2026041420192329500_dgae896-B34","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1210\/jc.2010-2743","article-title":"Cardiovascular complications of patients with aldosteronism associated with autonomous cortisol secretion","volume":"96","author":"Nakajima","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"2026041420192329500_dgae896-B35","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1210\/jc.2019-00299","article-title":"Impaired glucose metabolism in primary aldosteronism is associated with cortisol co-secretion","volume":"104","author":"Gerards","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"2026041420192329500_dgae896-B36","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.1210\/jc.2018-00617","article-title":"Cortisol excess in patients with primary aldosteronism impacts left ventricular hypertrophy","volume":"103","author":"Adolf","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"2026041420192329500_dgae896-B37","doi-asserted-by":"crossref","first-page":"5867","DOI":"10.1210\/jc.2019-01182","article-title":"Three discrete patterns of primary aldosteronism lateralization in response to cosyntropin during adrenal vein sampling","volume":"104","author":"Wannachalee","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"2026041420192329500_dgae896-B38","doi-asserted-by":"crossref","first-page":"e2338209","DOI":"10.1001\/jamanetworkopen.2023.38209","article-title":"Corticotropin stimulation in adrenal venous sampling for patients with primary aldosteronism: the ADOPA randomized clinical trial","volume":"6","author":"Yang","year":"2023","journal-title":"JAMA Netw Open"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgae896\/61281362\/dgae896.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/110\/9\/e2985\/61281362\/dgae896.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/110\/9\/e2985\/61281362\/dgae896.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:38:21Z","timestamp":1776213501000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/110\/9\/e2985\/7933259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,26]]},"references-count":38,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,12,26]]},"published-print":{"date-parts":[[2025,8,7]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgae896","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,9]]},"published":{"date-parts":[[2024,12,26]]}}}