{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T15:51:24Z","timestamp":1768405884490,"version":"3.49.0"},"reference-count":54,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Adelaide Research Scholarship","award":["2021\u201325"],"award-info":[{"award-number":["2021\u201325"]}]},{"DOI":"10.13039\/501100011958","name":"Independent Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011958","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Health and Medical Research Council of Australia Senior Research Fellowship","award":["1103020"],"award-info":[{"award-number":["1103020"]}]},{"name":"National Health and Medical Research Council of Australia Senior Research Fellowship","award":["2016\u201322"],"award-info":[{"award-number":["2016\u201322"]}]},{"name":"Diabetes Australia Research Project Grant","award":["2022-23"],"award-info":[{"award-number":["2022-23"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>In males of normal weight, intraduodenal administration of calcium enhances the effects of the amino acid L-tryptophan (Trp) to suppress energy intake, associated with greater stimulation of cholecystokinin (CCK), glucagon-like peptide-1 (GLP-1), and peptide tyrosine-tyrosine (PYY) secretion (key mechanisms underlying the regulation of pyloric motility and gastric emptying) but not gastrin or glucose-dependent insulinotropic polypeptide (GIP).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Given the implications for the management of obesity, the current study evaluated the effects of calcium, when administered alone and in combination with Trp, on gut hormone secretion, antropyloroduodenal motility, and energy intake in males with obesity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Fifteen males with obesity and without type 2 diabetes (mean \u00b1 SD; age: 27 \u00b1 8 years; body mass index: 30 \u00b1 2\u2005kg\/m2; hemoglobin A1c: 5.3 \u00b1 0.2%), received 150-minute intraduodenal infusions of 0, 500, or 1000\u2005mg calcium, each combined with Trp (load: 0.1 kcal\/min, known to have submaximal energy-intake suppressant effects) from t = 75-150\u2005minutes, on 3 separate occasions, in a randomized, double-blind, cross-over order. Plasma concentrations of gastrin, CCK, GIP, GLP-1, PYY, and pyloric pressures were measured during the infusions. Immediately postinfusion (t = 150-180\u2005minutes), energy intake at a standardized buffet-style lunch was quantified.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Calcium, in a dose of 1000\u2005mg, stimulated GLP-1, PYY, and pyloric pressures alone (all P &amp;lt; .05) and enhanced the effects of Trp to stimulate CCK, GLP-1, and PYY (all P &amp;lt; .05), associated with greater suppression of energy intake (P = .01). Energy intake (R = \u22120.64; P = .001) was inversely related to the dose of calcium, while plasma concentrations of CCK (R = 0.44; P = .05), GLP-1 (R = 0.60; P = .01), and PYY (R = 0.83; P = .01) were directly related.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Intraduodenal calcium enhances the effect of intraduodenal Trp to stimulate CCK, GLP-1, and PYY and suppress energy intake in males with obesity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf008","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T09:53:46Z","timestamp":1736416426000},"page":"e2929-e2938","source":"Crossref","is-referenced-by-count":4,"title":["Dose-related Effects of Calcium to Enhance the Effects of L-tryptophan on Gut Hormones and Energy Intake in Obesity"],"prefix":"10.1210","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5138-0339","authenticated-orcid":false,"given":"Javad","family":"Anjom-Shoae","sequence":"first","affiliation":[{"name":"Adelaide Medical School, University of Adelaide , Adelaide, SA 5005 ,","place":["Australia"]},{"name":"Centre of Research Excellence in Translating Nutritional Science to Good Health, University of Adelaide , Adelaide, SA 5005 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2775-9776","authenticated-orcid":false,"given":"Penelope C E","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Adelaide Medical School, University of Adelaide , Adelaide, SA 5005 ,","place":["Australia"]},{"name":"Centre of Research Excellence in Translating Nutritional Science to Good Health, University of Adelaide , Adelaide, SA 5005 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0942-0306","authenticated-orcid":false,"given":"Michael","family":"Horowitz","sequence":"additional","affiliation":[{"name":"Adelaide Medical School, University of Adelaide , Adelaide, SA 5005 ,","place":["Australia"]},{"name":"Centre of Research Excellence in Translating Nutritional Science to Good Health, University of Adelaide , Adelaide, SA 5005 ,","place":["Australia"]},{"name":"Endocrine and Metabolic Unit, Royal Adelaide Hospital , Adelaide, SA 5005 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens J","family":"Holst","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Copenhagen , DK-2200 Copenhagen ,","place":["Denmark"]},{"name":"The Novo Nordisk Foundation Centre for Basic Metabolic Research, University of Copenhagen , DK-2200 Copenhagen 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