{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:45:54Z","timestamp":1792788354894,"version":"4.5.0"},"reference-count":60,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Medical Science and Technology Project of Henan Province","award":["SBGJ202101014"],"award-info":[{"award-number":["SBGJ202101014"]}]},{"name":"Key Medical Science and Technology Project of Henan Province","award":["LHGJ20210322"],"award-info":[{"award-number":["LHGJ20210322"]}]},{"name":"Key Medical Science and Technology Project of Henan Province","award":["2023HYTP031"],"award-info":[{"award-number":["2023HYTP031"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>The use of glucagon-like peptide-1 receptor (GLP-1R) agonists such as semaglutide, a novel class of antidiabetic medications, has raised concerns about potential adverse effects, particularly a possible association with thyroid cancer (TC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to evaluate whether semaglutide influences the progression of TC by modulating tumor-associated macrophages (TAMs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Semaglutide was administered to human papillary thyroid carcinoma (PTC) xenograft mouse models, coculture systems consisting of human THP-1 macrophage cells and PTC cells, and primary murine peritoneal macrophages. Assessments included tumor size, M1\/M2 macrophage ratio, PTC cell proliferation, and polarization marker expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Semaglutide did not significantly impact the proliferation of PTC cells but reduced tumor size and inhibited the proliferation of PTC cells in coculture systems. It increased M1 and decreased M2 macrophages, reprogramming polarization by downregulating PPARG expression. Cotreatment with semaglutide and a PPARG agonist in the coculture system confirmed the upregulation of downstream genes RSAD2, ACSL1, and PLA2G7. Silencing ACSL1 inhibited lipid accumulation in THP-1 cells and promoted polarization toward the M2 macrophage phenotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Semaglutide modulates macrophage lipid metabolism through the GLP-1R\/PPARG\/ACSL1 signaling pathway. This modulation promotes the conversion of TAMs to the M1 macrophage phenotype, enhancing their anticancer activity. These findings suggest that semaglutide may improve therapeutic strategies, reduce unnecessary thyroid nodule screenings, and broaden its clinical applications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf053","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T12:52:31Z","timestamp":1738759951000},"page":"2777-2789","source":"Crossref","is-referenced-by-count":25,"title":["Semaglutide Reprograms Macrophages via the GLP-1R\/PPARG\/ACSL1 Pathway to Suppress Papillary Thyroid Carcinoma Growth"],"prefix":"10.1210","volume":"110","author":[{"given":"Longlong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Thyroid Surgery, the First Affiliated Hospital of Zhengzhou University, Engineering Research Center of Multidisciplinary Diagnosis and Treatment of Thyroid Cancer of Henan Province, Key Medicine Laboratory of Thyroid Cancer of Henan Province , Zhengzhou 450052 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lele","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Liver Transplantation, the First Affiliated Hospital of Zhengzhou University of Henan Province , Zhengzhou 450052 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runsheng","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Thyroid Surgery, the First Affiliated Hospital of Zhengzhou University, Engineering Research Center of Multidisciplinary Diagnosis and Treatment of Thyroid Cancer of Henan Province, Key Medicine Laboratory of Thyroid Cancer of Henan Province , Zhengzhou 450052 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Thyroid Surgery, the First Affiliated Hospital of Zhengzhou University, Engineering Research Center of Multidisciplinary Diagnosis and Treatment of Thyroid Cancer of Henan Province, Key Medicine Laboratory of Thyroid Cancer of Henan Province , Zhengzhou 450052 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qungang","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Thyroid Surgery, the First Affiliated Hospital of Zhengzhou University, Engineering Research Center of Multidisciplinary Diagnosis and Treatment of Thyroid Cancer of Henan Province, Key Medicine Laboratory of Thyroid Cancer of Henan Province , Zhengzhou 450052 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4349-6857","authenticated-orcid":false,"given":"Detao","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Thyroid Surgery, the First Affiliated Hospital of Zhengzhou University, Engineering Research Center of Multidisciplinary Diagnosis and Treatment of Thyroid Cancer of Henan Province, Key Medicine Laboratory of Thyroid Cancer of Henan Province , Zhengzhou 450052 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"issue":"1","key":"2025091917024729700_dgaf053-B1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12943-018-0786-0","article-title":"Novel targeted therapies and immunotherapy for advanced thyroid cancers","volume":"17","author":"Naoum","year":"2018","journal-title":"Mol Cancer"},{"issue":"10","key":"2025091917024729700_dgaf053-B2","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nrendo.2011.142","article-title":"Molecular genetics and diagnosis of thyroid cancer","volume":"7","author":"Nikiforov","year":"2011","journal-title":"Nat Rev Endocrinol"},{"issue":"4","key":"2025091917024729700_dgaf053-B3","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S2213-8587(22)00035-3","article-title":"The epidemiological landscape of thyroid cancer worldwide: GLOBOCAN estimates for incidence and mortality rates in 2020","volume":"10","author":"Pizzato","year":"2022","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"11","key":"2025091917024729700_dgaf053-B4","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1016\/j.mayocp.2021.04.028","article-title":"Incidence of clinically relevant thyroid cancers remains stable for almost a century: a population-based study","volume":"96","author":"Genere","year":"2021","journal-title":"Mayo Clin Proc"},{"issue":"24","key":"2025091917024729700_dgaf053-B5","doi-asserted-by":"crossref","first-page":"4808","DOI":"10.1002\/cncr.30943","article-title":"Changes in standardized mortality rates from thyroid cancer in Korea between 1985 and 2015: analysis of Korean national data","volume":"123","author":"Choi","year":"2017","journal-title":"Cancer"},{"issue":"24","key":"2025091917024729700_dgaf053-B6","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1161\/CIRCULATIONAHA.122.059595","article-title":"GLP-1 receptor agonists for the reduction of atherosclerotic cardiovascular risk in patients with type 2 diabetes","volume":"146","author":"Marx","year":"2022","journal-title":"Circulation"},{"issue":"2","key":"2025091917024729700_dgaf053-B7","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.tem.2016.10.001","article-title":"Glucagon-like peptide-1 and the central\/peripheral nervous system: crosstalk in diabetes","volume":"28","author":"Muscogiuri","year":"2017","journal-title":"Trends Endocrinol Metab"},{"key":"2025091917024729700_dgaf053-B8","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.atherosclerosis.2017.04.001","article-title":"Liraglutide, a GLP-1 receptor agonist, inhibits vascular smooth muscle cell proliferation by enhancing AMP-activated protein kinase and cell cycle regulation, and delays atherosclerosis in ApoE deficient mice","volume":"261","author":"Jojima","year":"2017","journal-title":"Atherosclerosis"},{"issue":"18","key":"2025091917024729700_dgaf053-B9","doi-asserted-by":"crossref","first-page":"7370","DOI":"10.1021\/acs.jmedchem.5b00726","article-title":"Discovery of the once-weekly glucagon-like peptide-1 (GLP-1) analogue semaglutide","volume":"58","author":"Lau","year":"2015","journal-title":"J Med Chem"},{"issue":"4","key":"2025091917024729700_dgaf053-B10","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1210\/en.2009-1272","article-title":"Glucagon-like peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation","volume":"151","author":"Bjerre Knudsen","year":"2010","journal-title":"Endocrinology"},{"issue":"4","key":"2025091917024729700_dgaf053-B11","first-page":"403","article-title":"Glucagon-like peptide-1 receptor agonists and thyroid cancer: a narrative review","volume":"34","author":"Espinosa De Ycaza","year":"2024","journal-title":"Thyroid"},{"issue":"2","key":"2025091917024729700_dgaf053-B12","doi-asserted-by":"crossref","first-page":"384","DOI":"10.2337\/dc22-1148","article-title":"GLP-1 receptor agonists and the risk of thyroid cancer","volume":"46","author":"Bezin","year":"2023","journal-title":"Diabetes Care"},{"issue":"7","key":"2025091917024729700_dgaf053-B13","doi-asserted-by":"crossref","first-page":"e2421305","DOI":"10.1001\/jamanetworkopen.2024.21305","article-title":"Glucagon-like peptide 1 receptor agonists and 13 obesity-associated cancers in patients with type 2 diabetes","volume":"7","author":"Wang","year":"2024","journal-title":"JAMA Netw Open"},{"issue":"2","key":"2025091917024729700_dgaf053-B14","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2337\/dci22-0052","article-title":"Putting GLP-1 RAs and thyroid cancer in context: additional evidence and remaining doubts","volume":"46","author":"Thompson","year":"2023","journal-title":"Diabetes Care"},{"issue":"1","key":"2025091917024729700_dgaf053-B15","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.immuni.2019.06.025","article-title":"Inflammation and cancer: triggers, mechanisms, and consequences","volume":"51","author":"Greten","year":"2019","journal-title":"Immunity"},{"issue":"9","key":"2025091917024729700_dgaf053-B16","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1007\/s00125-017-4330-3","article-title":"The GLP-1 analogue lixisenatide decreases atherosclerosis in insulin-resistant mice by modulating macrophage phenotype","volume":"60","author":"Vinu\u00e9","year":"2017","journal-title":"Diabetologia"},{"issue":"9","key":"2025091917024729700_dgaf053-B17","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1007\/s00125-012-2592-3","article-title":"Glucagon-like peptide-1 inhibits adipose tissue macrophage infiltration and inflammation in an obese mouse model of diabetes","volume":"55","author":"Lee","year":"2012","journal-title":"Diabetologia"},{"issue":"2","key":"2025091917024729700_dgaf053-B18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.metabol.2015.10.009","article-title":"Differential effects of GLP-1 receptor agonist on foam cell formation in monocytes between non-obese and obese subjects","volume":"65","author":"Tanaka","year":"2016","journal-title":"Metabolism"},{"issue":"4","key":"2025091917024729700_dgaf053-B19","doi-asserted-by":"crossref","first-page":"536","DOI":"10.3803\/EnM.2014.29.4.536","article-title":"Expression of glucagon-like peptide-1 receptor in papillary thyroid carcinoma and its clinicopathologic significance","volume":"29","author":"Jung","year":"2014","journal-title":"Endocrinol Metab (Seoul)"},{"key":"2025091917024729700_dgaf053-B20","doi-asserted-by":"crossref","first-page":"5621","DOI":"10.2147\/OTT.S150701","article-title":"Effects of insulin analogs and glucagon-like peptide-1 receptor agonists on proliferation and cellular energy metabolism in papillary thyroid cancer","volume":"10","author":"He","year":"2017","journal-title":"Onco Targets Ther"},{"key":"2025091917024729700_dgaf053-B21","doi-asserted-by":"crossref","unstructured":"Wang L, Zhang L, Ma R, Zhang Y, Chang Q, Yin D. \u00a0Data from: semaglutide reprograms macrophages via the GLP-1R\/PPARG\/ACSL1 pathway to suppress papillary thyroid carcinoma growth. Harvard Dataverse. 2025. Deposited 10 January 2025. 10.7910\/DVN\/HSPEW7","DOI":"10.1210\/clinem\/dgaf053"},{"issue":"12","key":"2025091917024729700_dgaf053-B22","doi-asserted-by":"crossref","first-page":"E1431","DOI":"10.1152\/ajpendo.00017.2014","article-title":"Activation of glucagon-like peptide-1 receptor inhibits growth and promotes apoptosis of human pancreatic cancer cells in a cAMP-dependent manner","volume":"306","author":"Zhao","year":"2014","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2025091917024729700_dgaf053-B23","doi-asserted-by":"crossref","first-page":"121137","DOI":"10.1016\/j.biomaterials.2021.121137","article-title":"M1 macrophage exosomes engineered to foster M1 polarization and target the IL-4 receptor inhibit tumor growth by reprogramming tumor-associated macrophages into M1-like macrophages","volume":"278","author":"Gunassekaran","year":"2021","journal-title":"Biomaterials"},{"issue":"5","key":"2025091917024729700_dgaf053-B24","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.jcmgh.2023.01.002","article-title":"Targeting notch1-YAP circuit reprograms macrophage polarization and alleviates acute liver injury in mice","volume":"15","author":"Yang","year":"2023","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"1","key":"2025091917024729700_dgaf053-B25","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/s41420-023-01621-9","article-title":"SCARB1 in extracellular vesicles promotes NPC metastasis by co-regulating M1 and M2 macrophage function","volume":"9","author":"Chen","year":"2023","journal-title":"Cell Death Discov"},{"issue":"14","key":"2025091917024729700_dgaf053-B26","doi-asserted-by":"crossref","first-page":"4802","DOI":"10.7150\/thno.83163","article-title":"5-aminolevulinate and CHIL3\/CHI3L1 treatment amid ischemia aids liver metabolism and reduces ischemia-reperfusion injury","volume":"13","author":"Jin","year":"2023","journal-title":"Theranostics"},{"key":"2025091917024729700_dgaf053-B27","doi-asserted-by":"crossref","first-page":"109505","DOI":"10.1016\/j.intimp.2022.109505","article-title":"Huc-MSCs-derived exosomes attenuate neuropathic pain by inhibiting activation of the TLR2\/MyD88\/NF-\u03baB signaling pathway in the spinal microglia by targeting rsad2","volume":"114","author":"Gao","year":"2023","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"2025091917024729700_dgaf053-B28","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1186\/s12885-024-11985-5","article-title":"PPARG activation promotes the proliferation of colorectal cancer cell lines and enhances the antiproliferative effect of 5-fluorouracil","volume":"24","author":"Sch\u00f6ckel","year":"2024","journal-title":"BMC Cancer"},{"issue":"1","key":"2025091917024729700_dgaf053-B29","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1038\/s41467-023-38233-x","article-title":"PPAR-\u03b3 regulates the effector function of human T helper 9 cells by promoting glycolysis","volume":"14","author":"Bertschi","year":"2023","journal-title":"Nat Commun"},{"issue":"24","key":"2025091917024729700_dgaf053-B30","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1161\/CIRCULATIONAHA.119.039610","article-title":"Preservation of acyl coenzyme A attenuates pathological and metabolic cardiac remodeling through selective lipid trafficking","volume":"139","author":"Goldenberg","year":"2019","journal-title":"Circulation"},{"issue":"9","key":"2025091917024729700_dgaf053-B31","doi-asserted-by":"crossref","first-page":"3988","DOI":"10.1111\/dom.15746","article-title":"The interaction effect between BMI, diabetes and age at diabetes onset on the risk of thyroid cancer: a population-based cohort study in Shanghai, China","volume":"26","author":"Hou","year":"2024","journal-title":"Diabetes Obes Metab"},{"issue":"3","key":"2025091917024729700_dgaf053-B32","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1158\/1055-9965.EPI-10-1220","article-title":"Obesity and thyroid cancer risk among U.S. Men and women: a pooled analysis of five prospective studies","volume":"20","author":"Kitahara","year":"2011","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"1","key":"2025091917024729700_dgaf053-B33","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s11154-023-09849-7","article-title":"Thyroid cancer and insulin resistance","volume":"25","author":"Brenta","year":"2024","journal-title":"Rev Endocr Metab Disord"},{"key":"2025091917024729700_dgaf053-B34","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-024-09141-7","article-title":"Outcomes and effectiveness of active surveillance for low-risk papillary thyroid carcinoma: a systematic review and meta-analysis","author":"Nguyen","year":"2024","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"8","key":"2025091917024729700_dgaf053-B35","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1210\/jc.2013-2118","article-title":"Differences in the recurrence and mortality outcomes rates of incidental and nonincidental papillary thyroid microcarcinoma: a systematic review and meta-analysis of 21 329 person-years of follow-up","volume":"99","author":"Mehanna","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2025091917024729700_dgaf053-B36","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1210\/clinem\/dgae575","article-title":"Molecular profiling of low-risk papillary thyroid carcinoma (mPTC) on active surveillance","volume":"110","author":"Ramone","year":"2025","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2025091917024729700_dgaf053-B37","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1210\/clinem\/dgac646","article-title":"Current controversies in low-risk differentiated thyroid cancer: reducing overtreatment in an era of overdiagnosis","volume":"108","author":"Ullmann","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2025091917024729700_dgaf053-B38","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/s41420-022-01214-y","article-title":"Pyruvate carboxylase promotes malignant transformation of papillary thyroid carcinoma and reduces iodine uptake","volume":"8","author":"Liu","year":"2022","journal-title":"Cell Death Discov"},{"key":"2025091917024729700_dgaf053-B39","doi-asserted-by":"crossref","first-page":"100939","DOI":"10.1016\/j.drup.2023.100939","article-title":"Radioiodine therapy in advanced differentiated thyroid cancer: resistance and overcoming strategy","volume":"68","author":"Liu","year":"2023","journal-title":"Drug Resist Updat"},{"issue":"1","key":"2025091917024729700_dgaf053-B40","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/dom.15292","article-title":"Risk of thyroid cancer associated with glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in patients with type 2 diabetes: a population-based cohort study","volume":"26","author":"Bea","year":"2024","journal-title":"Diabetes Obes Metab"},{"issue":"11","key":"2025091917024729700_dgaf053-B41","doi-asserted-by":"crossref","first-page":"5222","DOI":"10.1111\/dom.15869","article-title":"Long-term safety and efficacy of glucagon-like peptide-1 receptor agonists in individuals with obesity and without type 2 diabetes: a global retrospective cohort study","volume":"26","author":"Huang","year":"2024","journal-title":"Diabetes Obes Metab"},{"issue":"6","key":"2025091917024729700_dgaf053-B42","doi-asserted-by":"crossref","first-page":"e2080","DOI":"10.1210\/clinem\/dgae722","article-title":"Approach to the patient with thyroid nodules: considering GLP-1 receptor agonists","volume":"110","author":"Kelly","year":"2025","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"2025091917024729700_dgaf053-B43","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.1007\/s00262-023-03549-6","article-title":"Tumor-associated macrophages as a potential therapeutic target in thyroid cancers","volume":"72","author":"Zhu","year":"2023","journal-title":"Cancer Immunol Immunother"},{"issue":"7","key":"2025091917024729700_dgaf053-B44","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nrclinonc.2016.217","article-title":"Tumour-associated macrophages as treatment targets in oncology","volume":"14","author":"Mantovani","year":"2017","journal-title":"Nat Rev Clin Oncol"},{"issue":"11","key":"2025091917024729700_dgaf053-B45","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/s41573-022-00520-5","article-title":"Macrophages as tools and targets in cancer therapy","volume":"21","author":"Mantovani","year":"2022","journal-title":"Nat Rev Drug Discov"},{"issue":"6","key":"2025091917024729700_dgaf053-B46","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.jacbts.2018.09.004","article-title":"The GLP-1 analogs liraglutide and semaglutide reduce atherosclerosis in ApoE(-\/-) and LDLr(-\/-) mice by a mechanism that includes inflammatory pathways","volume":"3","author":"Rakipovski","year":"2018","journal-title":"JACC Basic Transl Sci"},{"issue":"1","key":"2025091917024729700_dgaf053-B47","doi-asserted-by":"crossref","first-page":"4589","DOI":"10.1038\/s41467-019-12332-0","article-title":"Pparg promotes differentiation and regulates mitochondrial gene expression in bladder epithelial cells","volume":"10","author":"Liu","year":"2019","journal-title":"Nat Commun"},{"issue":"5","key":"2025091917024729700_dgaf053-B48","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1158\/0008-5472.CAN-20-0652","article-title":"A transcriptional regulatory loop of master regulator transcription factors, PPARG, and fatty acid synthesis promotes esophageal adenocarcinoma","volume":"81","author":"Ma","year":"2021","journal-title":"Cancer Res"},{"key":"2025091917024729700_dgaf053-B49","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.micpath.2017.12.048","article-title":"Killing of S. aureus in murine peritoneal macrophages by ascorbic acid along with antibiotics chloramphenicol or ofloxacin: correlation with inflammation","volume":"115","author":"Dey","year":"2018","journal-title":"Microb Pathog"},{"key":"2025091917024729700_dgaf053-B50","doi-asserted-by":"crossref","first-page":"103214","DOI":"10.1016\/j.jaut.2024.103214","article-title":"PPARG-mediated autophagy activation alleviates inflammation in rheumatoid arthritis","volume":"146","author":"Geng","year":"2024","journal-title":"J Autoimmun"},{"key":"2025091917024729700_dgaf053-B51","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.intimp.2019.01.026","article-title":"S-allyl cysteine protects against lipopolysaccharide-induced acute kidney injury in the C57BL\/6 mouse strain: involvement of oxidative stress and inflammation","volume":"69","author":"Khajevand-Khazaei","year":"2019","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"2025091917024729700_dgaf053-B52","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13045-023-01478-6","article-title":"Metabolism, metabolites, and macrophages in cancer","volume":"16","author":"Li","year":"2023","journal-title":"J Hematol Oncol"},{"key":"2025091917024729700_dgaf053-B53","doi-asserted-by":"crossref","first-page":"155334","DOI":"10.1016\/j.metabol.2022.155334","article-title":"Loss of long-chain acyl-CoA synthetase 1 promotes hepatocyte death in alcohol-induced steatohepatitis","volume":"138","author":"Dong","year":"2023","journal-title":"Metabolism"},{"issue":"6","key":"2025091917024729700_dgaf053-B54","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1128\/MCB.01085-10","article-title":"Mouse cardiac acyl coenzyme a synthetase 1 deficiency impairs fatty acid oxidation and induces cardiac hypertrophy","volume":"31","author":"Ellis","year":"2011","journal-title":"Mol Cell Biol"},{"issue":"1","key":"2025091917024729700_dgaf053-B55","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.cmet.2010.05.012","article-title":"Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis","volume":"12","author":"Ellis","year":"2010","journal-title":"Cell Metab"},{"key":"2025091917024729700_dgaf053-B56","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.3389\/fimmu.2019.02410","article-title":"Long-chain acyl-CoA synthetase 1 role in sepsis and immunity: perspectives from a parallel review of public transcriptome datasets and of the literature","volume":"10","author":"Roelands","year":"2019","journal-title":"Front Immunol"},{"issue":"10","key":"2025091917024729700_dgaf053-B57","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1038\/s41388-021-01667-y","article-title":"Long-chain fatty acyl-CoA synthetase 1 promotes prostate cancer progression by elevation of lipogenesis and fatty acid beta-oxidation","volume":"40","author":"Ma","year":"2021","journal-title":"Oncogene"},{"issue":"10","key":"2025091917024729700_dgaf053-B58","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.1002\/jcb.29569","article-title":"The function of SNHG7\/miR-449a\/ACSL1 axis in thyroid cancer","volume":"121","author":"Guo","year":"2020","journal-title":"J Cell Biochem"},{"key":"2025091917024729700_dgaf053-B59","first-page":"82","article-title":"Adoptive transfer of metabolically reprogrammed macrophages for atherosclerosis treatment in diabetic ApoE (-\/-) mice","volume":"16","author":"Wang","year":"2022","journal-title":"Bioact Mater"},{"issue":"12","key":"2025091917024729700_dgaf053-B60","doi-asserted-by":"crossref","first-page":"E715","DOI":"10.1073\/pnas.1111600109","article-title":"Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1","volume":"109","author":"Kanter","year":"2012","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgaf053\/61770513\/dgaf053.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/110\/10\/2777\/61770513\/dgaf053.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/110\/10\/2777\/61770513\/dgaf053.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T21:03:02Z","timestamp":1758315782000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/110\/10\/2777\/8002732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,5]]},"references-count":60,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,2,5]]},"published-print":{"date-parts":[[2025,9,16]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgaf053","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,10]]},"published":{"date-parts":[[2025,2,5]]}}}