{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:02:58Z","timestamp":1792141378934,"version":"4.4.0"},"reference-count":39,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:00:00Z","timestamp":1739232000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Argentina"},{"DOI":"10.13039\/501100006668","name":"Fondo para la Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006668","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Agencia Nacional de Promoci\u00f3n de la Ciencia y Tecnolog\u00eda, Argentina","award":["R01 HD090071"],"award-info":[{"award-number":["R01 HD090071"]}]},{"name":"National Institute for Child Health and Human Development"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health, USA","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Delayed puberty is a frequent complaint in males. The differential diagnosis between self-limited delayed puberty (SLDP) and congenital hypogonadotropic hypogonadism (CHH) is challenging. Commonly used endocrine tests, focusing on stimulated levels of LH or testosterone, are not satisfactory in making a diagnosis. Because FSH action on Sertoli cells results in testis enlargement and anti-M\u00fcllerian hormone (AMH) and inhibin B increased secretion, and the FSH-Sertoli cell axis function is detectable during normal childhood and early puberty, we tested whether the assessment of serum FSH, AMH, and inhibin B would be informative to distinguish between SLDP and CHH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>We performed a prospective, nested case-control study in a cohort of male adolescents presenting with delayed puberty, comparing baseline serum reproductive hormone levels to identify predictive biomarkers of CHH, after having followed all participants prospectively until a final diagnosis was ascertained based on gold-standard criteria (age 18 years or \u22654 years after testis volume reached 4\u2005mL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 65 participants who completed follow-up, 33 had a final diagnosis of SLDP and 32 of CHH. Serum FSH, AMH, and inhibin B showed better diagnostic efficiency than LH and testosterone for these differential diagnoses. FSH (IU\/L)\u00d7inhibin B (pg\/mL) &amp;lt; 92 and FSH (IU\/L)\u00d7AMH (pmol\/L) &amp;lt; 537 showed high sensitivity (&amp;gt;93%), specificity (\u226592%), predictive values (&amp;gt;92%), and positive likelihood ratio (&amp;gt;12) for CHH. The diagnostic performance remained 89.7% and 88.2% for FSH \u00d7 inhibin B and FSH \u00d7 AMH, respectively, when analyzed in patients without red flags (micropenis, cryptorchidism, and\/or microorchidism).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Serum FSH combined with inhibin B or AMH is highly predictive to accurately distinguish between SLDP and CHH in adolescent males.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf062","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T15:18:36Z","timestamp":1739200716000},"page":"e3203-e3214","source":"Crossref","is-referenced-by-count":4,"title":["FSH and Sertoli Cell Biomarkers Accurately Distinguish Hypogonadotropic Hypogonadism From Self-limited Delayed Puberty"],"prefix":"10.1210","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8073-2046","authenticated-orcid":false,"given":"Sebasti\u00e1n","family":"Castro","sequence":"first","affiliation":[{"name":"Centro de Investigaciones Endocrinol\u00f3gicas \u201cDr. C\u00e9sar Bergad\u00e1\u201d (CEDIE), CONICET\u2014FEI\u2014Divisi\u00f3n de Endocrinolog\u00eda, Hospital de Ni\u00f1os Ricardo Guti\u00e9rrez , C1425EFD Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1583-1988","authenticated-orcid":false,"given":"Lourdes","family":"Correa Brito","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Endocrinol\u00f3gicas \u201cDr. C\u00e9sar Bergad\u00e1\u201d (CEDIE), CONICET\u2014FEI\u2014Divisi\u00f3n de Endocrinolog\u00eda, Hospital de Ni\u00f1os Ricardo Guti\u00e9rrez , C1425EFD Buenos Aires ,","place":["Argentina"]},{"name":"Unidad de Medicina Traslacional, Hospital de Ni\u00f1os Ricardo Guti\u00e9rrez , C1425EFD Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Bedecarr\u00e1s","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Endocrinol\u00f3gicas \u201cDr. C\u00e9sar Bergad\u00e1\u201d (CEDIE), CONICET\u2014FEI\u2014Divisi\u00f3n de Endocrinolog\u00eda, Hospital de Ni\u00f1os Ricardo Guti\u00e9rrez , C1425EFD Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0312-7421","authenticated-orcid":false,"given":"Mar\u00eda Gabriela","family":"Ballerini","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Endocrinol\u00f3gicas \u201cDr. C\u00e9sar Bergad\u00e1\u201d (CEDIE), CONICET\u2014FEI\u2014Divisi\u00f3n de Endocrinolog\u00eda, Hospital de Ni\u00f1os Ricardo Guti\u00e9rrez , C1425EFD Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Sans\u00f3","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Endocrinol\u00f3gicas \u201cDr. C\u00e9sar Bergad\u00e1\u201d (CEDIE), CONICET\u2014FEI\u2014Divisi\u00f3n de Endocrinolog\u00eda, Hospital de Ni\u00f1os Ricardo Guti\u00e9rrez , C1425EFD Buenos Aires ,","place":["Argentina"]},{"name":"Unidad de Medicina Traslacional, Hospital de Ni\u00f1os Ricardo Guti\u00e9rrez , C1425EFD Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Keselman","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Endocrinol\u00f3gicas \u201cDr. C\u00e9sar Bergad\u00e1\u201d (CEDIE), CONICET\u2014FEI\u2014Divisi\u00f3n de Endocrinolog\u00eda, Hospital de Ni\u00f1os Ricardo Guti\u00e9rrez , C1425EFD Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamilton","family":"Cassinelli","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Endocrinol\u00f3gicas \u201cDr. C\u00e9sar Bergad\u00e1\u201d (CEDIE), CONICET\u2014FEI\u2014Divisi\u00f3n de Endocrinolog\u00eda, Hospital de Ni\u00f1os Ricardo Guti\u00e9rrez , C1425EFD Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7618-1950","authenticated-orcid":false,"given":"Andrea Josefina","family":"Arcari","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Endocrinol\u00f3gicas \u201cDr. C\u00e9sar Bergad\u00e1\u201d (CEDIE), CONICET\u2014FEI\u2014Divisi\u00f3n de Endocrinolog\u00eda, Hospital de Ni\u00f1os Ricardo Guti\u00e9rrez , C1425EFD Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5780-7919","authenticated-orcid":false,"given":"Guillermo F","family":"Alonso","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Endocrinolog\u00eda Pedi\u00e1trica, Hospital Italiano de Buenos Aires , C1199ABB Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0554-8502","authenticated-orcid":false,"given":"Yee-Ming","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Pediatrics, Boston Children's Hospital , Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"He","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Pediatrics, Boston Children's Hospital , Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Gabriela","family":"Ropelato","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Endocrinol\u00f3gicas \u201cDr. C\u00e9sar Bergad\u00e1\u201d (CEDIE), CONICET\u2014FEI\u2014Divisi\u00f3n de Endocrinolog\u00eda, Hospital de Ni\u00f1os Ricardo Guti\u00e9rrez , C1425EFD Buenos Aires ,","place":["Argentina"]},{"name":"Unidad de Medicina Traslacional, Hospital de Ni\u00f1os Ricardo Guti\u00e9rrez , C1425EFD Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Bergad\u00e1","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Endocrinol\u00f3gicas \u201cDr. C\u00e9sar Bergad\u00e1\u201d (CEDIE), CONICET\u2014FEI\u2014Divisi\u00f3n de Endocrinolog\u00eda, Hospital de Ni\u00f1os Ricardo Guti\u00e9rrez , C1425EFD Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0958-5845","authenticated-orcid":false,"given":"Fernando","family":"Cassorla","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Materno Infantil (IDIM), Universidad de Chile , Santiago 8320000 ,","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1100-3843","authenticated-orcid":false,"given":"Rodolfo A","family":"Rey","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Endocrinol\u00f3gicas \u201cDr. C\u00e9sar Bergad\u00e1\u201d (CEDIE), CONICET\u2014FEI\u2014Divisi\u00f3n de Endocrinolog\u00eda, Hospital de Ni\u00f1os Ricardo Guti\u00e9rrez , C1425EFD Buenos Aires ,","place":["Argentina"]},{"name":"Unidad de Medicina Traslacional, Hospital de Ni\u00f1os Ricardo Guti\u00e9rrez , C1425EFD Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6291-1518","authenticated-orcid":false,"given":"Romina P","family":"Grinspon","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Endocrinol\u00f3gicas \u201cDr. C\u00e9sar Bergad\u00e1\u201d (CEDIE), CONICET\u2014FEI\u2014Divisi\u00f3n de Endocrinolog\u00eda, Hospital de Ni\u00f1os Ricardo Guti\u00e9rrez , C1425EFD Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2025,2,11]]},"reference":[{"issue":"5","key":"2026010810575266400_dgaf062-B1","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1210\/er.2018-00248","article-title":"Delayed puberty-phenotypic diversity, molecular genetic mechanisms, and recent discoveries","volume":"40","author":"Howard","year":"2019","journal-title":"Endocr Rev"},{"issue":"9","key":"2026010810575266400_dgaf062-B2","doi-asserted-by":"crossref","first-page":"e3693","DOI":"10.1210\/clinem\/dgab270","article-title":"Timing of pubertal onset in girls and boys with constitutional delay","volume":"106","author":"Jonsdottir-Lewis","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2026010810575266400_dgaf062-B3","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1210\/clinem\/dgac054","article-title":"An approach to the patient with delayed puberty","volume":"107","author":"Harrington","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2026010810575266400_dgaf062-B4","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S2213-8587(22)00339-4","article-title":"Molecular basis of normal and pathological puberty: from basic mechanisms to clinical implications","volume":"11","author":"Argente","year":"2023","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"2","key":"2026010810575266400_dgaf062-B5","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1210\/er.2018-00116","article-title":"Clinical management of congenital hypogonadotropic hypogonadism","volume":"40","author":"Young","year":"2019","journal-title":"Endocr Rev"},{"issue":"1","key":"2026010810575266400_dgaf062-B6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.2047-2927.2012.00008.x","article-title":"Male hypogonadism: an extended classification based on a developmental, endocrine physiology-based approach","volume":"1","author":"Rey","year":"2013","journal-title":"Andrology"},{"key":"2026010810575266400_dgaf062-B7","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.coemr.2020.07.007","article-title":"The importance of follicle-stimulating hormone in the prepubertal and pubertal testis","volume":"14","author":"Grinspon","year":"2020","journal-title":"Curr Opin Endocr Metab Res"},{"issue":"9","key":"2026010810575266400_dgaf062-B8","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1210\/jc.2012-1598","article-title":"Clinical review: distinguishing constitutional delay of growth and puberty from isolated hypogonadotropic hypogonadism: critical appraisal of available diagnostic tests","volume":"97","author":"Harrington","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"5pt2","key":"2026010810575266400_dgaf062-B9","doi-asserted-by":"crossref","first-page":"e487","DOI":"10.1111\/j.1365-2605.2011.01210.x","article-title":"Early onset of primary hypogonadism revealed by serum anti-M\u00fcllerian hormone determination during infancy and childhood in trisomy 21","volume":"34","author":"Grinspon","year":"2011","journal-title":"Int J Androl"},{"issue":"5","key":"2026010810575266400_dgaf062-B10","first-page":"401","article-title":"Longitud y di\u00e1metro del pene en ni\u00f1os de 0 a 14 a\u00f1os de edad","volume":"103","author":"Anigstein","year":"2005","journal-title":"Arch Argent Pediatr"},{"key":"2026010810575266400_dgaf062-B11","doi-asserted-by":"crossref","DOI":"10.1097\/00000441-195909000-00030","volume-title":"Radiographic Atlas of Skeletal Development of the Hand and Wrist","author":"Greulich","year":"1959"},{"issue":"5","key":"2026010810575266400_dgaf062-B12","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1159\/000439051","article-title":"Hypogonadotropic hypogonadism in infants with congenital hypopituitarism: a challenge to diagnose at an early stage","volume":"84","author":"Braslavsky","year":"2015","journal-title":"Horm Res Paediatr"},{"key":"2026010810575266400_dgaf062-B13","doi-asserted-by":"crossref","first-page":"1354715","DOI":"10.3389\/fgene.2024.1354715","article-title":"Case report: novel SIN3A loss-of-function variant as causative for hypogonadotropic hypogonadism in Witteveen-Kolk syndrome","volume":"15","author":"Correa Brito","year":"2024","journal-title":"Front Genet"},{"issue":"12","key":"2026010810575266400_dgaf062-B14","doi-asserted-by":"crossref","first-page":"e1580","DOI":"10.1210\/clinem\/dgad373","article-title":"Prevalence of deleterious variants in MC3R in patients with constitutional delay of growth and puberty","volume":"108","author":"Duckett","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2026010810575266400_dgaf062-B15","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"2026010810575266400_dgaf062-B16","doi-asserted-by":"crossref","first-page":"20","DOI":"10.12688\/wellcomeopenres.10069.1","article-title":"Accurate clinical detection of exon copy number variants in a targeted NGS panel using DECoN","volume":"1","author":"Fowler","year":"2016","journal-title":"Wellcome Open Res"},{"issue":"5","key":"2026010810575266400_dgaf062-B17","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/j.1365-2265.2011.04297.x","article-title":"Gonadotrophin secretion pattern in anorchid boys from birth to pubertal age: pathophysiological aspects and diagnostic usefulness","volume":"76","author":"Grinspon","year":"2012","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2026010810575266400_dgaf062-B18","doi-asserted-by":"crossref","first-page":"1135467","DOI":"10.3389\/fendo.2023.1135467","article-title":"Testicular dysfunction at diagnosis in children and teenagers with haematopoietic malignancies improves after initial chemotherapy","volume":"14","author":"Lopez Dacal","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2026010810575266400_dgaf062-B19","volume-title":"Hypogonadotropic Hypogonadism Versus Self-Limited Delayed Puberty","author":"Castro","year":"2024"},{"issue":"3","key":"2026010810575266400_dgaf062-B20","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s12020-021-02626-z","article-title":"ENDO-ERN expert opinion on the differential diagnosis of pubertal delay","volume":"71","author":"Persani","year":"2021","journal-title":"Endocrine"},{"issue":"6","key":"2026010810575266400_dgaf062-B21","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1210\/jc.2009-2732","article-title":"Basal follicle-stimulating hormone and peak gonadotropin levels after gonadotropin-releasing hormone infusion show high diagnostic accuracy in boys with suspicion of hypogonadotropic hypogonadism","volume":"95","author":"Grinspon","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"2026010810575266400_dgaf062-B22","first-page":"CR511","article-title":"Plasma inhibin B and antimullerian hormone concentrations in boys: discriminating between congenital hypogonadotropic hypogonadism and constitutional pubertal delay","volume":"16","author":"Adan","year":"2010","journal-title":"Med Sci Monit"},{"issue":"1","key":"2026010810575266400_dgaf062-B23","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/cen.12613","article-title":"Inhibin B plus LH vs GnRH agonist test for distinguishing constitutional delay of growth and puberty from isolated hypogonadotropic hypogonadism in boys","volume":"82","author":"Binder","year":"2015","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"5","key":"2026010810575266400_dgaf062-B24","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1111\/andr.12088","article-title":"AMH, but not INSL3, IGF1 or DHEAS support differentiation between constitutional delay of growth and puberty and hypogonadotropic hypogonadism","volume":"3","author":"Rohayem","year":"2015","journal-title":"Andrology"},{"issue":"1","key":"2026010810575266400_dgaf062-B25","first-page":"147","article-title":"Congenital hypogonadotropic hypogonadism, functional hypogonadotropism or constitutional delay of growth and puberty? An analysis of a large patient series from a single tertiary center","volume":"32","author":"Varimo","year":"2017","journal-title":"Hum Reprod"},{"issue":"9","key":"2026010810575266400_dgaf062-B26","doi-asserted-by":"crossref","first-page":"e3495","DOI":"10.1210\/clinem\/dgab357","article-title":"FSH stimulated inhibin B (FSH-iB): a novel marker for the accurate prediction of pubertal outcome in delayed puberty","volume":"106","author":"Chaudhary","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"2026010810575266400_dgaf062-B27","doi-asserted-by":"crossref","first-page":"5225","DOI":"10.1210\/jc.2010-1535","article-title":"Baseline inhibin B and anti-mullerian hormone measurements for diagnosis of hypogonadotropic hypogonadism (HH) in boys with delayed puberty","volume":"95","author":"Coutant","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"2026010810575266400_dgaf062-B28","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1210\/endrev\/bnae003","article-title":"Mini-Puberty, physiological and disordered: consequences, and potential for therapeutic replacement","volume":"45","author":"Rohayem","year":"2024","journal-title":"Endocr Rev"},{"key":"2026010810575266400_dgaf062-B29","doi-asserted-by":"crossref","first-page":"101619","DOI":"10.1016\/j.beem.2022.101619","article-title":"Genetics of cryptorchidism and testicular regression","volume":"36","author":"Elamo","year":"2022","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"2026010810575266400_dgaf062-B30","doi-asserted-by":"crossref","first-page":"1069741","DOI":"10.3389\/fendo.2022.1069741","article-title":"Genetic architecture of self-limited delayed puberty and congenital hypogonadotropic hypogonadism","volume":"13","author":"Vezzoli","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"4","key":"2026010810575266400_dgaf062-B31","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1530\/EJE-17-0568","article-title":"Congenital hypogonadotropic hypogonadism and constitutional delay of growth and puberty have distinct genetic architectures","volume":"178","author":"Cassatella","year":"2018","journal-title":"Eur J Endocrinol"},{"issue":"2","key":"2026010810575266400_dgaf062-B32","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1530\/EJE-18-0764","article-title":"New genetic findings in a large cohort of congenital hypogonadotropic hypogonadism","volume":"181","author":"Amato","year":"2019","journal-title":"Eur J Endocrinol"},{"issue":"4","key":"2026010810575266400_dgaf062-B33","first-page":"168","article-title":"Diagnostic utility of a low-dose gonadotropin-releasing hormone test in the context of puberty disorders","volume":"62","author":"Zevenhuijzen","year":"2004","journal-title":"Horm Res"},{"issue":"10","key":"2026010810575266400_dgaf062-B34","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1093\/humrep\/deaa185","article-title":"GnRH stimulation testing and serum inhibin B in males: insufficient specificity for discriminating between congenital hypogonadotropic hypogonadism from constitutional delay of growth and puberty","volume":"35","author":"Mosbah","year":"2020","journal-title":"Hum Reprod"},{"key":"2026010810575266400_dgaf062-B35","doi-asserted-by":"crossref","first-page":"1226839","DOI":"10.3389\/fendo.2023.1226839","article-title":"Key features of puberty onset and progression can help distinguish self-limited delayed puberty from congenital hypogonadotrophic hypogonadism","volume":"14","author":"Aung","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"2","key":"2026010810575266400_dgaf062-B36","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1530\/EJE-12-0191","article-title":"The pubertal transition in 179 healthy danish children: associations between pubarche, adrenarche, gonadarche, and body composition","volume":"168","author":"Mouritsen","year":"2013","journal-title":"Eur J Endocrinol"},{"issue":"2","key":"2026010810575266400_dgaf062-B37","doi-asserted-by":"crossref","first-page":"160","DOI":"10.4103\/ijem.ijem_448_21","article-title":"Accuracy of various tests alone and in combination to differentiate IHH from CDGP","volume":"26","author":"Mishra","year":"2022","journal-title":"Indian J Endocrinol Metab"},{"issue":"8","key":"2026010810575266400_dgaf062-B38","doi-asserted-by":"crossref","first-page":"e2717","DOI":"10.1210\/clinem\/dgaa162","article-title":"Using Kisspeptin to predict pubertal outcomes for youth with pubertal delay","volume":"105","author":"Chan","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2026010810575266400_dgaf062-B39","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1210\/jcem.87.4.8395","article-title":"Delayed puberty: analysis of a large case series from an academic center","volume":"87","author":"Sedlmeyer","year":"2002","journal-title":"J Clin Endocrinol Metab"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgaf062\/61839229\/dgaf062.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/110\/10\/e3203\/61839229\/dgaf062.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/110\/10\/e3203\/61839229\/dgaf062.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T15:58:05Z","timestamp":1767887885000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/110\/10\/e3203\/8008323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,11]]},"references-count":39,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,2,11]]},"published-print":{"date-parts":[[2025,9,16]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgaf062","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,10]]},"published":{"date-parts":[[2025,2,11]]}}}