{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:23:43Z","timestamp":1787635423910,"version":"build-2736575974"},"reference-count":40,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University Research Institute of Maternal and Child Health and Precision Medicine"},{"name":"National and Kapodistrian University of Athens, Athens, Greece, by Osteofit Hellas, Inc"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Osteoporosis is characterized by reduced bone mineral density (BMD) and disrupted microarchitecture estimated by trabecular bone score (TBS). Osteostrong\u00ae is a bone-strengthening system implementing 4 devices and incorporating brief (10-minute), weekly, low-impact, high-intensity osteogenic loading exercises. The aim of this study was to assess changes in BMD and TBS in the lumbar spine and\/or hip over 12 months in peri-\/post menopausal women with Osteoporosis following Osteostrong\u00ae intervention and to compare these outcomes with women who did not receive such intervention.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and Subjects<\/jats:title>\n                  <jats:p>A quasi-experimental case-series study in which 147 participants were separated into 2 groups, following informed consent: 75 in group A receiving Osteostrong\u00ae (subgroup G1 without and G2 with antiresorptive medication); and 72 in group B without Osteostrong\u00ae (subgroup G3 without and G4 with antiresorptive medication). Changes in lumbar spine and hip BMD and\/or TBS were assessed at inclusion and 12 months later. Bonferroni-adjusted non-parametric paired tests examined for significant paired mean differences within each subgroup.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>After Bonferroni adjustment, significant increases were observed in lumbar spine BMD in G2 (mean paired change: 0.029 g\/cm2; Bonferroni-adjusted p &amp;lt; 0.001), and G4 (mean paired change: 0.025 g\/cm2; Bonferroni-adjusted p = 0.05) as well as BMD-total hip left in G2 (mean paired change: 0.028 g\/cm2; Bonferroni-adjusted p = 0.05). Other within-group changes in femoral neck BMD, total hip BMD, and TBS did not retain significance following Bonferroni correction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The Osteostrong\u00ae intervention showed modest lumbar spine BMD improvements over 12 months; some subgroup effects were significant but not when Bonferroni-adjusted, warranting cautious interpretation and further randomized trials.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf077","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T06:51:26Z","timestamp":1738911086000},"page":"e2878-e2887","source":"Crossref","is-referenced-by-count":7,"title":["Brief, Low-impact, High-intensity Osteogenic Loading in Postmenopausal Osteoporosis: A Quasi-experimental Case-series 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