{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:02:28Z","timestamp":1791820948255,"version":"4.3.4"},"reference-count":38,"publisher":"The Endocrine Society","issue":"11","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001349","name":"Singapore National Medical Research Council","doi-asserted-by":"crossref","award":["000066"],"award-info":[{"award-number":["000066"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001349","name":"Singapore National Medical Research Council","doi-asserted-by":"crossref","award":["000714-01"],"award-info":[{"award-number":["000714-01"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001349","name":"Singapore National Medical Research Council","doi-asserted-by":"crossref","award":["001327-02"],"award-info":[{"award-number":["001327-02"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Khoo Teck Puat Hospital","award":["STAR23104"],"award-info":[{"award-number":["STAR23104"]}]},{"name":"Khoo Teck Puat Hospital","award":["AHFPG22001"],"award-info":[{"award-number":["AHFPG22001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The rate of decline in estimated glomerular filtration rate (eGFR) varies among patients with type 2 diabetes (T2D). We aimed to identify plasma proteins associated with diverse eGFR trajectories in T2D.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed latent class mixed models analysis among patients with T2D and relatively preserved kidney function (baseline eGFR \u226560 mL\/min\/1.73 m2) from the Singapore Study of Macro-angiopathy and Micro-Vascular Reactivity in Type 2 Diabetes (SMART2D) (n = 1285) and diabetic nephropathy (n = 798) cohorts to identify patterns of eGFR trajectories. Comprehensive proteomic association with eGFR trajectories was assessed using multivariable logistic regression in the SMART2D cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Three distinct eGFR trajectories groups\u2014slow decline (92.2%), progressive decline (4.0%), and accelerated decline (3.8%)\u2014were identified in SMART2D and validated in the diabetic nephropathy cohort. Participants in the accelerated decline group exhibited the highest risk of progression to end-stage kidney disease (log-rank test, P &amp;lt; .0001). Among 1448 proteins analyzed in the SMART2D cohort, 19 proteins, including KIM-1 (odds ratio [OR] = 2.95; 95% CI, 2.01-4.32; P = 2.95 \u00d7 10\u22128), MMP7 (OR = 16.5; 95% CI, 5.54-49.07; P = 4.61 \u00d7 10\u22127), and VSIG4 (OR = 7.38; 95% CI, 3.22-16.89; P = 2.24 \u00d7 10\u22126), were associated with accelerated decline and 1 protein (OR = 6.34; 95% CI, 2.77-14.52; P = 1.26 \u00d7 10\u22125) was associated with progressive decline, independent of traditional cardiorenal risk factors including baseline kidney function. Adding these proteins to clinical risk factors (age, sex, ethnicity, eGFR, urine albumin-to-creatinine ratio, HbA1c, diabetes duration, systolic blood pressure, triglyceride) improved area under the curve to 0.77 (delta 0.04, P = .057) for progressive decline and 0.93 (delta 0.09, P &amp;lt; .001) for accelerated decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Different plasma proteins are associated with progressive and accelerated eGFR decline, independent of traditional cardiorenal risk factors, some of which enhance eGFR trajectory prediction in patients with T2D.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf095","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T23:22:10Z","timestamp":1739402530000},"page":"3256-3263","source":"Crossref","is-referenced-by-count":6,"title":["Plasma Proteins Predict Kidney Function Trajectories in Type 2 Diabetes"],"prefix":"10.1210","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8772-4452","authenticated-orcid":false,"given":"Resham L","family":"Gurung","sequence":"first","affiliation":[{"name":"Clinical Research Unit, Khoo Teck Puat Hospital , Singapore 768828 , Singapore"},{"name":"Cardiovascular and Metabolic Disorders Signature Research Program, Duke-NUS Medical School , Singapore 169857, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huili","family":"Zheng","sequence":"additional","affiliation":[{"name":"Clinical Research Unit, Khoo Teck Puat Hospital , Singapore 768828 , Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia Le Ivan","family":"Tan","sequence":"additional","affiliation":[{"name":"Clinical Research Unit, Khoo Teck Puat Hospital , Singapore 768828 , 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Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1742-5817","authenticated-orcid":false,"given":"Su Chi","family":"Lim","sequence":"additional","affiliation":[{"name":"Clinical Research Unit, Khoo Teck Puat Hospital , Singapore 768828 , Singapore"},{"name":"Saw Swee Hock School of Public Health, National University of Singapore , Singapore 117549 , Singapore"},{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University , Singapore 308232 , Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2025,2,14]]},"reference":[{"issue":"4","key":"2025101519564085600_dgaf095-B1","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1053\/j.ajkd.2014.08.001","article-title":"Diabetic kidney disease: a report from an ADA consensus conference","volume":"64","author":"Tuttle","year":"2014","journal-title":"Am J Kidney 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