{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:09:22Z","timestamp":1790874562350,"version":"4.1.0"},"reference-count":64,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Immunohistochemistry (IHC) of cell lineage-specific transcription factors (TFs) has been added to the histopathological classification of pituitary adenomas since 2017, resulting in new histopathological subtypes of TF+\/hormone\u2212non-functioning pituitary adenomas (NFPAs) and a reduction in the prevalence of null cell adenomas (NCAs).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This work aimed to evaluate associations between expression of cell lineage-specific TFs by IHC and radiological invasion and prognosis of NFPAs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data sources<\/jats:title>\n                  <jats:p>A literature search in Medline, Embase, and CENTRAL was performed from inception up to July 11, 2023.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study selection<\/jats:title>\n                  <jats:p>Eligible studies were cohort studies reporting on radiological invasion, recurrence, and\/or radiotherapy in patients with NFPAs who tested positive for one cell lineage-specific TF or negative for all 3. Finally, 27 out of 1985 studies were included.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data extraction<\/jats:title>\n                  <jats:p>Two authors independently extracted data and critically appraised risk of bias using the Quality In Prognostic Studies (QUIPS) tool.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data synthesis<\/jats:title>\n                  <jats:p>Random-effects inverse variance models were used to pool effect sizes. Prevalence rate ratios (PRRs) were calculated using the Mantel-Haenszel method. Cavernous sinus invasion was more prevalent in NCAs and TPIT+ NFPAs compared with SF1+ NFPAs (PRR 1.60; 95% CI, 1.22-2.08, I2 10%, 95% prediction interval [PrI] 1.23-2.06; P = .0036, and PRR 1.43; 95% CI, 1.21-1.70, I2 0%, 95% PrI 1.17-1.76; P = .0017, respectively), and in NCAs compared with PIT1+ (PRR 1.44; 95% CI, 1.01-2.06, I2 0%, 95% PrI 0.83-2.50; P = .0454). A limited number of studies precluded data syntheses of recurrence and radiotherapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The use of cell lineage-specific TFs by IHC enables to detect histopathological subtypes of NFPAs with distinct clinical behavior.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf112","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T17:32:52Z","timestamp":1740159172000},"page":"e2362-e2382","source":"Crossref","is-referenced-by-count":5,"title":["Cell Lineage-Specific Differences in Clinical Behavior of Non-Functioning Pituitary Adenomas"],"prefix":"10.1210","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4912-3616","authenticated-orcid":false,"given":"Loren S","family":"van der Hoeven","sequence":"first","affiliation":[{"name":"Amsterdam UMC, University of Amsterdam, Department of 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Department of Endocrinology and Metabolism , 1105 AZ, Amsterdam , the","place":["Netherlands"]},{"name":"Amsterdam UMC, University of Amsterdam, Department of Neurosurgery , 1105 AZ, Amsterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2758-2509","authenticated-orcid":false,"given":"Madeleine L","family":"Drent","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, University of Amsterdam, Department of Endocrinology and Metabolism, Pituitary Center Amsterdam , 1105 AZ, Amsterdam ,","place":["the Netherlands"]},{"name":"European Reference Network on Rare Endocrine Conditions (Endo-ERN), Coordinated from Amsterdam UMC, University of Amsterdam, Department of Endocrinology and Metabolism, 1105 AZ, Amsterdam, the \u00a0","place":["Netherlands"]},{"name":"Amsterdam UMC, Vrije Univerisiteit Amsterdam, Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology and Metabolism (AGEM) , 1084 HV, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3542-3770","authenticated-orcid":false,"given":"Eleonora","family":"Aronica","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, University of Amsterdam, Department of Endocrinology and Metabolism, Pituitary Center Amsterdam , 1105 AZ, Amsterdam ,","place":["the Netherlands"]},{"name":"Amsterdam UMC, University of Amsterdam, Department of (Neuro)Pathology , 1105 AZ, Amsterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9519-5140","authenticated-orcid":false,"given":"Dirk Jan","family":"Stenvers","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, University of Amsterdam, Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology and Metabolism (AGEM), 1105 AZ, Amsterdam, the \u00a0","place":["Netherlands"]},{"name":"Amsterdam UMC, University of Amsterdam, Department of Endocrinology and Metabolism, Pituitary Center Amsterdam , 1105 AZ, Amsterdam ,","place":["the Netherlands"]},{"name":"European Reference Network on Rare Endocrine Conditions (Endo-ERN), Coordinated from Amsterdam UMC, University of Amsterdam, Department of Endocrinology and Metabolism, 1105 AZ, Amsterdam, the \u00a0","place":["Netherlands"]},{"name":"Amsterdam UMC, Vrije Univerisiteit Amsterdam, Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology and Metabolism (AGEM) , 1084 HV, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1194-9866","authenticated-orcid":false,"given":"Alberto M","family":"Pereira","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, University of Amsterdam, Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology and 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