{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:17:01Z","timestamp":1785802621024,"version":"3.56.0"},"reference-count":48,"publisher":"The Endocrine Society","issue":"11","license":[{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1004602"],"award-info":[{"award-number":["2018YFC1004602"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82261128001"],"award-info":[{"award-number":["82261128001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974235"],"award-info":[{"award-number":["81974235"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Shenkang Program","award":["SHDC12022119"],"award-info":[{"award-number":["SHDC12022119"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>While the association between maternal thyroid peroxidase antibody (TPOAb) positivity and preterm birth (PTB) risk has been established, the association between thyroglobulin antibody (TgAb) and PTB remains unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This study aimed to explore the association between TgAb and PTB risk in euthyroid women.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This single-center, prospective cohort study enrolled euthyroid women in the first trimester. Data on serum concentrations of thyrotropin (TSH), free thyroxine (FT4), TgAb, and TPOAb were collected. Participants were categorized into 2 groups (TgAb-negative and TgAb-positive). PTB was subtyped into spontaneous PTB (S-PTB) and medically induced PTB (MI-PTB); and into early PTB (E-PTB) and late PTB (L-PTB). Logistic regression models examined the associations between TgAb and PTB and its subtypes, with stratification by first-trimester TSH levels (0.1-2.5 mIU\/L, 2.5-4.0 mIU\/L).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>This study comprised 58 247 euthyroid pregnant women. Adjusting for confounders, TgAb positivity was associated with a 16% increased risk of PTB (adjusted odds ratio (aOR) 1.16, 95% CI, 1.03-1.29; P = .01) compared to the TgAb-negative group. Specifically, TgAb positivity showed a higher risk of S-PTB and L-PTB, aOR 1.22 (95% CI, 1.06-1.39) and aOR 1.17 (95% CI, 1.04-1.32), respectively. Consistent results were observed when analyzing TgAb concentration as a continuous variable. TSH stratification analysis revealed that these associations were statistically significant only among women with TSH levels between 0.1 and 2.5 mIU\/L.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In euthyroid women, TgAb positivity was associated with a higher risk of PTB that mainly manifested as S-PTB and L-PTB. However, the clinical significance of these findings is limited.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf118","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T06:05:26Z","timestamp":1740463526000},"page":"e3841-e3849","source":"Crossref","is-referenced-by-count":5,"title":["Association of Maternal Thyroglobulin Antibody With Preterm Birth in Euthyroid Women"],"prefix":"10.1210","volume":"110","author":[{"given":"Shuai","family":"Yang","sequence":"first","affiliation":[{"name":"The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai 200030 ,","place":["China"]},{"name":"Shanghai Key Laboratory of Embryo Original Diseases , Shanghai 200030 ,","place":["China"]},{"name":"Shanghai Municipal Key Clinical Specialty , Shanghai 200030 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