{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:47:20Z","timestamp":1787021240721,"version":"build-2736575974"},"reference-count":61,"publisher":"The Endocrine Society","issue":"11","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Societ\u00e0 Italiana dell\u2019Osteoporosi"},{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"publisher","award":["PNRR-MAD-2022-12376632"],"award-info":[{"award-number":["PNRR-MAD-2022-12376632"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"publisher","award":["PRIN-2020YRETTX"],"award-info":[{"award-number":["PRIN-2020YRETTX"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"publisher","award":["PNRR-MAD-2022-12376779"],"award-info":[{"award-number":["PNRR-MAD-2022-12376779"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Both primary hyperparathyroidism (PHPT) and chronic hypoparathyroidism (HypoPT) are associated with the onset and development of cardiovascular diseases (CVDs). However, the molecular mechanisms underlying the effects of parathyroid disorders on endothelial dysfunction and platelet aggregation, two main determinants of CVDs, are not completely understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This work aimed to evaluate the effects of PHPT and HypoPT on oxidative stress and endothelial and platelet function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This monocentric cross-sectional study at an outpatient clinic included 40 individuals with HypoPT, 40 with PHPT, and 40 age- and sex-matched control participants. Main outcome measures included circulating levels of markers of oxidative stress, endothelial function, and platelet activation, calcium metabolism parameters, flow-mediated vasodilation (FMD), and carotid intimal-media thickness (IMT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HypoPT and PHPT patients showed increased oxidative stress markers as compared to control participants (P &amp;lt; .001). Among patients with parathyroid disorders, those with PHPT demonstrated the highest reduction of nitric oxide (P &amp;lt; .001 vs HypoPT and controls) and FMD (P &amp;lt; .001 and P = .001) and a marked increase of IMT (P &amp;lt; .001 and P = .001). We also observed an increased platelet aggregation in patients with parathyroid disorders, with the highest values in PHPT patients (P &amp;lt; .001, PHPT vs controls; P = .006, HypoPT vs controls; P &amp;lt; .001, PHPT vs HypoPT), along with increased levels of soluble P selectin and thromboxane B2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PHPT and HypoPT patients have increased markers of atherothrombotic risk due to endothelial and platelet function alterations. Our results suggests that parathyroid hormone may influence platelet reactivity. Further research is needed to determine if personalized antiplatelet therapy is necessary in individuals with parathyroid disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf138","type":"journal-article","created":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T15:18:01Z","timestamp":1740842281000},"page":"e3745-e3755","source":"Crossref","is-referenced-by-count":8,"title":["Platelet Function and Markers of Atherothrombotic Risk in Individuals With Parathyroid Disorders"],"prefix":"10.1210","volume":"110","author":[{"given":"Anda Mihaela","family":"Naciu","sequence":"first","affiliation":[{"name":"Unit of Metabolic Bone and Thyroid Disorders, Fondazione Policlinico Universitario Campus Bio-Medico , Rome 00128 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5616-3197","authenticated-orcid":false,"given":"Annunziata","family":"Nusca","sequence":"additional","affiliation":[{"name":"Department of Medicine, Unit of Cardiac Sciences, Campus Bio-Medico University of Rome , Rome 00128 ,","place":["Italy"]},{"name":"Cardiology Unit, Fondazione Policlinico Universitario Campus Bio-Medico of Rome , Rome 00128 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1143-4926","authenticated-orcid":false,"given":"Andrea","family":"Palermo","sequence":"additional","affiliation":[{"name":"Unit of Metabolic Bone and Thyroid Disorders, Fondazione Policlinico Universitario Campus Bio-Medico , Rome 00128 ,","place":["Italy"]},{"name":"Unit of Endocrinology and Diabetes, Campus Bio-Medico University , Rome 00128 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Piccirillo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Unit of Cardiac Sciences, Campus Bio-Medico University of Rome , Rome 00128 ,","place":["Italy"]},{"name":"Cardiology Unit, Fondazione Policlinico Universitario Campus Bio-Medico of Rome , Rome 00128 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia","family":"Tabacco","sequence":"additional","affiliation":[{"name":"Unit of Metabolic Bone and Thyroid Disorders, Fondazione Policlinico Universitario Campus Bio-Medico , Rome 00128 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"D\u2019Amico","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome , Latina 04100 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso Maria","family":"Di Tommaso","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology and Diabetes, Campus Bio-Medico University , Rome 00128 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Sterpetti","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology and Diabetes, Campus Bio-Medico University , Rome 00128 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele Mattia","family":"Viscusi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Unit of Cardiac Sciences, Campus Bio-Medico University of Rome , Rome 00128 ,","place":["Italy"]},{"name":"Cardiology Unit, Fondazione Policlinico Universitario Campus Bio-Medico of Rome , Rome 00128 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Bernardini","sequence":"additional","affiliation":[{"name":"Department of Medicine, Unit of Cardiac Sciences, Campus Bio-Medico University of Rome , Rome 00128 ,","place":["Italy"]},{"name":"Cardiology Unit, Fondazione Policlinico Universitario Campus Bio-Medico of Rome , Rome 00128 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Forte","sequence":"additional","affiliation":[{"name":"IRCCS Neuromed , Pozzilli 86077 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"D\u2019Ambrosio","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome , Latina 04100 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Frati","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome , Latina 04100 ,","place":["Italy"]},{"name":"IRCCS Neuromed , Pozzilli 86077 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Nocella","sequence":"additional","affiliation":[{"name":"Department of Clinical Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome , Rome 00161 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Napoli","sequence":"additional","affiliation":[{"name":"Unit of Metabolic Bone and Thyroid Disorders, Fondazione Policlinico Universitario Campus Bio-Medico , Rome 00128 ,","place":["Italy"]},{"name":"Unit of Endocrinology and Diabetes, Campus Bio-Medico University , Rome 00128 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6216-9595","authenticated-orcid":false,"given":"Roberto","family":"Carnevale","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome , Latina 04100 ,","place":["Italy"]},{"name":"IRCCS Neuromed , Pozzilli 86077 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiano","family":"Sciarretta","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome , Latina 04100 ,","place":["Italy"]},{"name":"IRCCS Neuromed , Pozzilli 86077 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4767-7073","authenticated-orcid":false,"given":"Francesco","family":"Grigioni","sequence":"additional","affiliation":[{"name":"Department of Medicine, Unit of Cardiac Sciences, Campus Bio-Medico University of Rome , Rome 00128 ,","place":["Italy"]},{"name":"Cardiology Unit, Fondazione Policlinico Universitario Campus Bio-Medico of Rome , Rome 00128 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2025,3,4]]},"reference":[{"issue":"11","key":"2025101519574824900_dgaf138-B1","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1002\/jbmr.4677","article-title":"Evaluation and management of primary hyperparathyroidism: summary statement and guidelines from the fifth international workshop","volume":"37","author":"Bilezikian","year":"2022","journal-title":"J Bone Miner Res"},{"issue":"12","key":"2025101519574824900_dgaf138-B2","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1002\/jbmr.4716","article-title":"Management of hypoparathyroidism","volume":"37","author":"Khan","year":"2022","journal-title":"J Bone Miner Res"},{"issue":"11","key":"2025101519574824900_dgaf138-B3","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1002\/jbmr.4665","article-title":"Epidemiology, pathophysiology and genetics of primary hyperparathyroidism","volume":"37","author":"Minisola","year":"2022","journal-title":"J Bone Miner Res"},{"issue":"11","key":"2025101519574824900_dgaf138-B4","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1007\/s40618-018-0879-z","article-title":"Clinical presentation and management of patients with primary hyperparathyroidism in Italy","volume":"41","author":"Saponaro","year":"2018","journal-title":"J Endocrinol Invest"},{"issue":"2","key":"2025101519574824900_dgaf138-B5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.14797\/mdcj-13-2-49","article-title":"The parathyroid gland and heart disease","volume":"13","author":"Brown","year":"2017","journal-title":"Methodist Debakey Cardiovasc J"},{"issue":"6","key":"2025101519574824900_dgaf138-B6","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.beem.2018.06.006","article-title":"Non classical complications of primary hyperparathyroidism","volume":"32","author":"Chiodini","year":"2018","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"2025101519574824900_dgaf138-B7","doi-asserted-by":"crossref","first-page":"1113913","DOI":"10.3389\/fneur.2023.1113913","article-title":"Leg restlessness and hyperparathyroidism in Parkinson's disease, a further clue to RLS pathogenesis?","volume":"14","author":"Marano","year":"2023","journal-title":"Front Neurol"},{"issue":"7","key":"2025101519574824900_dgaf138-B8","doi-asserted-by":"crossref","first-page":"e2609","DOI":"10.1210\/clinem\/dgaa174","article-title":"Clinical, biochemical, and radiological profile of normocalcemic primary hyperparathyroidism","volume":"105","author":"Palermo","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2025101519574824900_dgaf138-B9","doi-asserted-by":"crossref","first-page":"R297","DOI":"10.1530\/EJE-17-0485","article-title":"Cardiovascular manifestations of primary hyperparathyroidism: a narrative review","volume":"177","author":"Pepe","year":"2017","journal-title":"Eur J Endocrinol"},{"issue":"11","key":"2025101519574824900_dgaf138-B10","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1002\/jbmr.4679","article-title":"Classical and nonclassical manifestations of primary hyperparathyroidism","volume":"37","author":"El-Hajj Fuleihan","year":"2022","journal-title":"J Bone Miner Res"},{"issue":"3-4","key":"2025101519574824900_dgaf138-B11","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ando.2020.02.003","article-title":"Cardiovascular consequences of parathyroid disorders in adults","volume":"82","author":"Bollerslev","year":"2021","journal-title":"Ann Endocrinol (Paris)"},{"issue":"8","key":"2025101519574824900_dgaf138-B12","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.1007\/s12325-021-01787-7","article-title":"Risk of cardiovascular conditions in patients with chronic hypoparathyroidism: a retrospective cohort study","volume":"38","author":"Gosmanova","year":"2021","journal-title":"Adv Ther"},{"issue":"1","key":"2025101519574824900_dgaf138-B13","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s12020-019-02101-w","article-title":"Cardiovascular autonomic neuropathy as a cause of fatigue in chronic hypoparathyroidism","volume":"67","author":"Tabacco","year":"2020","journal-title":"Endocrine"},{"issue":"3","key":"2025101519574824900_dgaf138-B14","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/jbmr.3623","article-title":"Cardiovascular autonomic neuropathy as a new complication of post-surgical chronic hypoparathyroidism","volume":"34","author":"Tabacco","year":"2019","journal-title":"J Bone Miner Res"},{"issue":"4","key":"2025101519574824900_dgaf138-B15","first-page":"374","article-title":"Central and peripheral blood pressures and arterial stiffness increase in hypoparathyroidism","volume":"64","author":"Pamuk","year":"2020","journal-title":"Arch Endocrinol Metab"},{"issue":"6220","key":"2025101519574824900_dgaf138-B16","doi-asserted-by":"crossref","first-page":"1260419","DOI":"10.1126\/science.1260419","article-title":"Proteomics. Tissue-based map of the human proteome","volume":"347","author":"Uhl\u00e9n","year":"2015","journal-title":"Science"},{"issue":"12","key":"2025101519574824900_dgaf138-B17","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1007\/s000180200015","article-title":"ERKs are the point of divergence of PKA and PKC activation by PTHrP in human skin fibroblasts","volume":"59","author":"Fortino","year":"2002","journal-title":"Cell Mol Life Sci"},{"issue":"7","key":"2025101519574824900_dgaf138-B18","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1042\/CS20070010","article-title":"Effect of parathyroid-hormone-related protein on human platelet activation","volume":"113","author":"Ortega","year":"2007","journal-title":"Clin Sci"},{"issue":"1","key":"2025101519574824900_dgaf138-B19","doi-asserted-by":"crossref","first-page":"6971","DOI":"10.1038\/s41598-024-57090-2","article-title":"NADPH oxidase 2 mediates cardiac sympathetic denervation and myocyte autophagy, resulting in cardiac atrophy and dysfunction in doxorubicin-induced cardiomyopathy","volume":"14","author":"Ma","year":"2024","journal-title":"Sci Rep"},{"issue":"9","key":"2025101519574824900_dgaf138-B20","doi-asserted-by":"crossref","first-page":"911","DOI":"10.33963\/KP.a2022.0130","article-title":"Low-grade endotoxemia and NOX2 in patients with coronary microvascular angina","volume":"80","author":"Loffredo","year":"2022","journal-title":"Kardiol Pol"},{"issue":"2","key":"2025101519574824900_dgaf138-B21","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3390\/antiox12020429","article-title":"Structure, activation, and regulation of NOX2: at the crossroad between the innate immunity and oxidative stress-mediated pathologies","volume":"12","author":"Nocella","year":"2023","journal-title":"Antioxidants"},{"issue":"34","key":"2025101519574824900_dgaf138-B22","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1093\/eurheartj\/ehab484","article-title":"2021 ESC guidelines on cardiovascular disease prevention in clinical practice","volume":"42","author":"Visseren","year":"2021","journal-title":"Eur Heart J"},{"issue":"7","key":"2025101519574824900_dgaf138-B23","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1111\/bcp.13589","article-title":"Oleuropein, a component of extra virgin olive oil, lowers postprandial glycaemia in healthy subjects","volume":"84","author":"Carnevale","year":"2018","journal-title":"Br J Clin Pharmacol"},{"issue":"30","key":"2025101519574824900_dgaf138-B24","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1093\/eurheartj\/ehz350","article-title":"Expert consensus and evidence-based recommendations for the assessment of flow-mediated dilation in humans","volume":"40","author":"Thijssen","year":"2019","journal-title":"Eur Heart J"},{"issue":"17","key":"2025101519574824900_dgaf138-B25","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1056\/NEJMc1109714","article-title":"Carotid intima-media thickness and cardiovascular events","volume":"365","author":"Inaba","year":"2011","journal-title":"N Engl J Med"},{"issue":"9","key":"2025101519574824900_dgaf138-B26","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1002\/jbmr.2501","article-title":"The epidemiology of nonsurgical hypoparathyroidism in Denmark: a nationwide case finding study","volume":"30","author":"Underbjerg","year":"2015","journal-title":"J Bone Miner Res"},{"key":"2025101519574824900_dgaf138-B27","doi-asserted-by":"crossref","first-page":"e230053","DOI":"10.20945\/2359-4292-2023-0053","article-title":"Coronary calcium score in patients with post-surgical hypoparathyroidism","volume":"68","author":"de Souza Sartori","year":"2024","journal-title":"Arch Endocrinol Metab"},{"issue":"8","key":"2025101519574824900_dgaf138-B28","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1007\/s40618-023-02271-5","article-title":"Presentation of hypoparathyroidism in Italy: a nationwide register-based study","volume":"47","author":"Cipriani","year":"2024","journal-title":"J Endocrinol Invest"},{"key":"2025101519574824900_dgaf138-B29","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.amjcard.2023.01.029","article-title":"Association of serum calcium and phosphate with incident cardiovascular disease in patients with hypoparathyroidism","volume":"194","author":"Kaul","year":"2023","journal-title":"Am J Cardiol"},{"issue":"4","key":"2025101519574824900_dgaf138-B30","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/cen.14872","article-title":"Coronary artery disease and its vascular associates in patients with chronic nonsurgical hypoparathyroidism","volume":"98","author":"Saha","year":"2023","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"11","key":"2025101519574824900_dgaf138-B31","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1002\/jbmr.1979","article-title":"Cardiovascular and renal complications to postsurgical hypoparathyroidism: a Danish nationwide controlled historic follow-up study","volume":"28","author":"Underbjerg","year":"2013","journal-title":"J Bone Miner Res"},{"issue":"3-4","key":"2025101519574824900_dgaf138-B32","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ando.2020.02.005","article-title":"PTH and cardiovascular risk","volume":"82","author":"Gruson","year":"2021","journal-title":"Ann Endocrinol (Paris)"},{"issue":"1","key":"2025101519574824900_dgaf138-B33","doi-asserted-by":"crossref","first-page":"9582319","DOI":"10.1155\/2018\/9582319","article-title":"Parathyroid hormone causes endothelial dysfunction by inducing mitochondrial ROS and specific oxidative signal transduction modifications","volume":"2018","author":"Gambardella","year":"2018","journal-title":"Oxid Med Cell Longev"},{"issue":"3","key":"2025101519574824900_dgaf138-B34","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s10353-016-0457-6","article-title":"Oxidative stress and angiogenesis in primary hyperparathyroidism","volume":"49","author":"Deska","year":"2017","journal-title":"Eur Surg"},{"issue":"1","key":"2025101519574824900_dgaf138-B35","doi-asserted-by":"crossref","first-page":"20","DOI":"10.4183\/aeb.2022.20","article-title":"Effect of parathyroidectomy on oxidative stress in patients with primary hyperparathyroidism","volume":"18","author":"Abdulrahman","year":"2022","journal-title":"Acta Endocrinol (Bucharest, Rom 2005)"},{"issue":"4","key":"2025101519574824900_dgaf138-B36","doi-asserted-by":"crossref","first-page":"4242","DOI":"10.3390\/ijms24044242","article-title":"Neuroinflammation and oxidative stress in individuals affected by DiGeorge syndrome","volume":"24","author":"Menghi","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"4","key":"2025101519574824900_dgaf138-B37","doi-asserted-by":"crossref","first-page":"F1215","DOI":"10.1152\/ajprenal.00406.2006","article-title":"Parathyroid hormone stimulates endothelial expression of atherosclerotic parameters through protein kinase pathways","volume":"292","author":"Rashid","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"issue":"10","key":"2025101519574824900_dgaf138-B38","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1093\/ndt\/gfm269","article-title":"Parathyroid hormone stimulates the endothelial nitric oxide synthase through protein kinase A and C pathways","volume":"22","author":"Rashid","year":"2007","journal-title":"Nephrol Dial Transplant"},{"issue":"11","key":"2025101519574824900_dgaf138-B39","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.3390\/jcm11113146","article-title":"Arterial stiffness in thyroid and parathyroid disease: a review of clinical studies","volume":"11","author":"Grillo","year":"2022","journal-title":"J Clin Med"},{"issue":"7","key":"2025101519574824900_dgaf138-B40","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/BF03346518","article-title":"Endothelial function and endothelial nitric oxide synthase intron 4a\/b polymorphism in primary hyperparathyroidism","volume":"32","author":"Ekmekci","year":"2009","journal-title":"J Endocrinol Invest"},{"key":"2025101519574824900_dgaf138-B41","doi-asserted-by":"crossref","first-page":"935977","DOI":"10.3389\/fmed.2022.935977","article-title":"Effects of normal reference range of phosphorus and corresponding PTH on endothelial function in CKD patients","volume":"9","author":"Lee","year":"2022","journal-title":"Front Med"},{"issue":"24","key":"2025101519574824900_dgaf138-B42","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1016\/j.jacc.2014.02.572","article-title":"Endothelial NADPH oxidase-2 promotes interstitial cardiac fibrosis and diastolic dysfunction through proinflammatory effects and endothelial-mesenchymal transition","volume":"63","author":"Murdoch","year":"2014","journal-title":"J Am Coll Cardiol"},{"issue":"8","key":"2025101519574824900_dgaf138-B43","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1210\/jc.2018-02456","article-title":"Effect of parathyroidectomy on cardiovascular risk factors in primary hyperparathyroidism: a randomized clinical trial","volume":"104","author":"Ejlsmark-Svensson","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2025101519574824900_dgaf138-B44","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1210\/clinem\/dgab157","article-title":"Meta-analysis on the effect of mild primary hyperparathyroidism and parathyroidectomy upon arterial stiffness","volume":"106","author":"Bernardi","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2025101519574824900_dgaf138-B45","doi-asserted-by":"crossref","first-page":"262","DOI":"10.4103\/2230-8210.149320","article-title":"Carotid, aorta and renal arteries intima-media thickness in patients with sporadic idiopathic hypoparathyroidism","volume":"19","author":"Meena","year":"2015","journal-title":"Indian J Endocrinol Metab"},{"issue":"5","key":"2025101519574824900_dgaf138-B46","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/cen.13418","article-title":"Is primary hyperparathyroidism a cause of endothelial dysfunction?","volume":"87","author":"Colak","year":"2017","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"6B","key":"2025101519574824900_dgaf138-B47","first-page":"887","article-title":"Intima-media thickness measurement of the carotid artery in patients with primary hyperparathyroidism. A prospective case-control study and long-term follow-up","volume":"20","author":"Lumachi","year":"2006","journal-title":"In Vivo (Brooklyn)"},{"issue":"4","key":"2025101519574824900_dgaf138-B48","doi-asserted-by":"crossref","first-page":"293","DOI":"10.4274\/tjh.2015.0087","article-title":"The effect of hyperparathyroid state on platelet functions and bone loss","volume":"33","author":"Yorulmaz","year":"2016","journal-title":"Turkish J Haematol"},{"issue":"4","key":"2025101519574824900_dgaf138-B49","doi-asserted-by":"crossref","first-page":"182","DOI":"10.4149\/endo_2014_04_182","article-title":"Assessment of mean platelet volume (MPV) in primary hyperparathyroidism: effects of successful parathyroidectomy on MPV levels","volume":"48","author":"Yilmaz","year":"2014","journal-title":"Endocr Regul"},{"key":"2025101519574824900_dgaf138-B50","doi-asserted-by":"crossref","first-page":"1295040","DOI":"10.3389\/fendo.2023.1295040","article-title":"Assessing causal associations of hyperparathyroidism with blood counts and biochemical indicators: a Mendelian randomization study","volume":"14","author":"Jiang","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"6","key":"2025101519574824900_dgaf138-B51","first-page":"612","article-title":"Multisociety consensus quality improvement revised consensus statement for endovascular therapy of acute ischemic stroke","volume":"13","author":"Sacks","year":"2018","journal-title":"Int J Stroke"},{"issue":"7","key":"2025101519574824900_dgaf138-B52","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1080\/09537104.2020.1817358","article-title":"High extracellular phosphate increases platelet polyphosphate content","volume":"32","author":"Abbasian","year":"2021","journal-title":"Platelets"},{"issue":"4","key":"2025101519574824900_dgaf138-B53","doi-asserted-by":"crossref","DOI":"10.1111\/eci.12902","article-title":"PTH, vitamin D, and the FGF-23-klotho axis and heart: going beyond the confines of nephrology","volume":"48","author":"Navarro-Garc\u00eda","year":"2018","journal-title":"Eur J Clin Invest"},{"issue":"4","key":"2025101519574824900_dgaf138-B54","doi-asserted-by":"crossref","first-page":"bvac027","DOI":"10.1210\/jendso\/bvac027","article-title":"Parathyroid hormone regulates circulating levels of sclerostin and FGF23 in a primary hyperparathyroidism model","volume":"6","author":"Nagata","year":"2022","journal-title":"J Endocr Soc"},{"issue":"3","key":"2025101519574824900_dgaf138-B55","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1507\/endocrj.K06-156","article-title":"Fibroblast growth factor-23 (FGF23) in patients with transient hypoparathyroidism: its important role in serum phosphate regulation","volume":"54","author":"Yamashita","year":"2007","journal-title":"Endocr J"},{"issue":"1","key":"2025101519574824900_dgaf138-B56","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/s12882-020-01826-5","article-title":"Interaction between serum FGF-23 and PTH in renal phosphate excretion, a case-control study in hypoparathyroid patients","volume":"21","author":"Saki","year":"2020","journal-title":"BMC Nephrol"},{"issue":"1","key":"2025101519574824900_dgaf138-B57","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/ki.2012.327","article-title":"Higher fibroblast growth factor-23 increases the risk of all-cause and cardiovascular mortality in the community","volume":"83","author":"\u00c4rnl\u00f6v","year":"2013","journal-title":"Kidney Int"},{"key":"2025101519574824900_dgaf138-B58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2017.03.042","article-title":"Fibroblast growth factor 23 as a predictor of cardiovascular and all-cause mortality in prospective studies","volume":"261","author":"Qin","year":"2017","journal-title":"Atherosclerosis"},{"issue":"10","key":"2025101519574824900_dgaf138-B59","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1210\/me.2009-0098","article-title":"Endogenous parathyroid hormone-related protein regulates the expression of PTH type 1 receptor and proliferation of vascular smooth muscle cells","volume":"23","author":"Song","year":"2009","journal-title":"Mol Endocrinol"},{"issue":"4","key":"2025101519574824900_dgaf138-B60","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1161\/01.HYP.23.4.468","article-title":"Parathyroid hormone\/adenylate cyclase coupling in vascular smooth muscle cells","volume":"23","author":"Hanson","year":"1994","journal-title":"Hypertension"},{"issue":"6","key":"2025101519574824900_dgaf138-B61","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1161\/ATVBAHA.112.300934","article-title":"Nitroglycerine-induced vasodilation for assessment of vascular function: a comparison with flow-mediated vasodilation","volume":"33","author":"Maruhashi","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgaf138\/62262385\/dgaf138.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/110\/11\/e3745\/62262385\/dgaf138.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/110\/11\/e3745\/62262385\/dgaf138.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T23:58:03Z","timestamp":1760572683000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/110\/11\/e3745\/8051508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,4]]},"references-count":61,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,3,4]]},"published-print":{"date-parts":[[2025,10,16]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgaf138","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,11]]},"published":{"date-parts":[[2025,3,4]]}}}