{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:52:00Z","timestamp":1792547520437,"version":"4.5.0"},"reference-count":35,"publisher":"The Endocrine Society","issue":"11","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI22\/01525"],"award-info":[{"award-number":["PI22\/01525"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Postoperative outcomes of patients with normotensive pheochromocytomas are poorly documented.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We aimed to evaluate the impact of preoperative hypertension on postoperative outcomes following adrenalectomy for pheochromocytoma.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>An international retrospective study of patients undergoing adrenalectomy for pheochromocytoma in 46 centers between 2012 and 2022 was performed. Hypertensive and normotensive pheochromocytoma were defined respectively by the presence or absence of hypertension history before or at the time of pheochromocytoma diagnosis. To evaluate differences in postoperative outcomes between hypertensive and normotensive patients, propensity score matched (PSM) analysis was performed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 2016 patients with pheochromocytoma, 1034 (51.2%) had preoperative hypertension and 982 (49.8%) were normotensive. Hypertensive patients were 4.5 years older (P &amp;lt; .001), had a higher prevalence of type 2 diabetes (P &amp;lt; .001), had a higher median Charlson Comorbidity Index (2.0 vs 1.0; P &amp;lt; .001), and had an American Society of Anesthesiologists score of III to IV more frequently (41% vs 19.9%; P &amp;lt; .001) than normotensive patients. Nonadjusted analysis demonstrated that hypertensive patients had longer operative time (115.0 vs 103.5\u2005minutes; P = .026), higher rate of vasopressors at skin closure (19.7% vs 15.4%; P = .013), more perioperative blood transfusions (7.7% vs 5.0%; P = .016), and an increased complication rate (21.6% vs 17.7%; P = .029). However, after 1:1 PSM, we found that readmission, complications, and serious complications were similar between cohorts.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Patients with hypertensive pheochromocytomas have a higher risk of postoperative complications than normotensive patients due to the association of hypertension with a higher burden of comorbidities and older age. However, hypertension is not an independent risk factor of postoperative complications after pheochromocytoma surgery.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf154","type":"journal-article","created":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T16:09:36Z","timestamp":1741277376000},"page":"e3719-e3729","source":"Crossref","is-referenced-by-count":7,"title":["Postoperative Outcomes in Normotensive and Hypertensive Pheochromocytomas: An International Study"],"prefix":"10.1210","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0519-0072","authenticated-orcid":false,"given":"Marta","family":"Araujo-Castro","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Hospital Universitario Ram\u00f3n y Cajal , Madrid 28034 ,","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Ram\u00f3n y Cajal (YRICIS) , Madrid 28034 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aura","family":"Herrera","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, University Hospital Reina Sofia , Cordoba 14004 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Jilin University , Changchun, Jilin 2699 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Jilin University , Changchun, Jilin 2699 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"\u015aledzi\u0144ski","sequence":"additional","affiliation":[{"name":"Division of General, Endocrine and Transplant Surgery, Medical University of Gda\u0144sk , Gda\u0144sk 80210 ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Hellmann","sequence":"additional","affiliation":[{"name":"Division of General, Endocrine and Transplant Surgery, Medical University of Gda\u0144sk , Gda\u0144sk 80210 ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1259-2491","authenticated-orcid":false,"given":"Marco","family":"Raffaelli","sequence":"additional","affiliation":[{"name":"UOC Chirurgia Endocrina e Metabolica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Centro di Ricerca in Chirurgia Endocrina e dell'Obesit\u00e0, Universit\u00e0 Cattolica del Sacro Cuore , Rome 00136 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0865-700X","authenticated-orcid":false,"given":"Francesco","family":"Pennestr\u00ec","sequence":"additional","affiliation":[{"name":"UOC Chirurgia Endocrina e Metabolica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Centro di Ricerca in Chirurgia Endocrina e dell'Obesit\u00e0, Universit\u00e0 Cattolica del Sacro Cuore , Rome 00136 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Sywak","sequence":"additional","affiliation":[{"name":"Endocrine Surgical Unit, Royal North Shore Hospital, Northern Sydney Local Health District , Sydney, NSW 2065 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4634-5963","authenticated-orcid":false,"given":"Alexander J","family":"Papachristos","sequence":"additional","affiliation":[{"name":"Endocrine 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,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Aspinall","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Aberdeen Royal Infirmary , Aberdeen AB25 2ZN ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross","family":"Melvin","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Aberdeen Royal Infirmary , Aberdeen AB25 2ZN ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Wen Liang Lau","sequence":"additional","affiliation":[{"name":"Division of Breast & Endocrine Surgery, Department of General Surgery, Ng Teng Fong General Hospital (NTFGH), National University Health System (NUHS) , Singapore 609606 ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei Keat","family":"Cheah","sequence":"additional","affiliation":[{"name":"Division of Breast & Endocrine 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