{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:37:08Z","timestamp":1790102228575,"version":"4.0.1"},"reference-count":40,"publisher":"The Endocrine Society","issue":"12","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Elisabeth Foundation","award":["91716453"],"award-info":[{"award-number":["91716453"]}]},{"name":"Elisabeth Foundation","award":["024.005.010"],"award-info":[{"award-number":["024.005.010"]}]},{"DOI":"10.13039\/501100002999","name":"Dutch Ministry of Health, Welfare and Sport","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002999","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005075","name":"University Medical Center Groningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005075","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>The use of corticosteroids (CS) has been associated with higher body mass index (BMI) and waist circumference (WC) in cross-sectional studies. However, longitudinal data are scarce, particularly for locally administered forms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>We analyzed weight and waist circumference changes in 81 361 Lifelines Cohort Study participants (mean age 46.3 years, mean BMI 26.0\u2005kg\/m2, 41% male, mean follow-up 3.9 years) via linear regression. Sensitivity analyses included stratification by sex and BMI. Short-term weight changes post-start were assessed in a subset using linear mixed-effect models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found 23.8% CS users during the study period. Individuals reporting any new use of CS gained significantly more weight compared to nonusers at follow-up (\u03b2 .034\u2005kg\/year, P = .021), particularly among those initiating local CS use (\u03b2 .037\u2005kg\/year, P = .017). Use of new systemic CS was associated with increased WC (\u03b2 .200\u2005cm\/year, P &amp;lt; .001). Discontinuation of CS led to decreased WC (\u03b2 \u2212.078\u2005cm\/year, P = .028). These effects were particularly observed in female participants and individuals with BMI \u226525\u2005kg\/m2, but not in male participants and those with BMI &amp;lt; 25\u2005kg\/m2. Short-term weight-inducing effects of CS were not observed in the weeks after initiation of CS use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates that CS use, including locally administered forms, is associated with long-term increases in weight and WC, notably in female individuals and those with overweight or obesity. Discontinuing CS was linked to reductions in WC. These findings underscore the need to carefully assess chronic systemic and local CS use, as discontinuation could benefit obesity-related outcomes in certain patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf166","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T10:13:33Z","timestamp":1743588813000},"page":"e3989-e3997","source":"Crossref","is-referenced-by-count":10,"title":["Corticosteroid Use and Long-Term Changes in Weight and Waist Circumference: The Lifelines Cohort Study"],"prefix":"10.1210","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0021-5477","authenticated-orcid":false,"given":"Mostafa","family":"Mohseni","sequence":"first","affiliation":[{"name":"Obesity Center CGG, Erasmus MC, University Medical Center Rotterdam , P.O. Box 2400, 3000 CA Rotterdam ,","place":["the Netherlands"]},{"name":"Division of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam , P.O. Box 2400, 3000 CA Rotterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5134-5453","authenticated-orcid":false,"given":"Eline S","family":"van der Valk","sequence":"additional","affiliation":[{"name":"Obesity Center CGG, Erasmus MC, University Medical Center Rotterdam , P.O. Box 2400, 3000 CA Rotterdam ,","place":["the Netherlands"]},{"name":"Division of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam , P.O. Box 2400, 3000 CA Rotterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maartje J B","family":"Van der Hurk","sequence":"additional","affiliation":[{"name":"Obesity Center CGG, Erasmus MC, University Medical Center Rotterdam , P.O. Box 2400, 3000 CA Rotterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5223-1140","authenticated-orcid":false,"given":"Mesut","family":"Savas","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam , P.O. Box 2400, 3000 CA Rotterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari\u00ebtte R","family":"Boon","sequence":"additional","affiliation":[{"name":"Obesity Center CGG, Erasmus MC, University Medical Center Rotterdam , P.O. Box 2400, 3000 CA Rotterdam ,","place":["the Netherlands"]},{"name":"Division of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam , P.O. Box 2400, 3000 CA Rotterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0120-4913","authenticated-orcid":false,"given":"Elisabeth F C","family":"van Rossum","sequence":"additional","affiliation":[{"name":"Obesity Center CGG, Erasmus MC, University Medical Center Rotterdam , P.O. Box 2400, 3000 CA Rotterdam ,","place":["the Netherlands"]},{"name":"Division of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam , P.O. 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