{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:34:09Z","timestamp":1790022849016,"version":"4.0.1"},"reference-count":37,"publisher":"The Endocrine Society","issue":"12","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF19OC0058872"],"award-info":[{"award-number":["NNF19OC0058872"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF18OC0052953"],"award-info":[{"award-number":["NNF18OC0052953"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>The beneficial effects of a ketogenic diet (KD) on neurodegenerative conditions such as mild cognitive impairment (MCI) and Alzheimer disease (AD) are increasingly acknowledged, with potential implications for the general population as well.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Thus, our study aimed to explore the effect of a KD on cerebral blood flow (CBF) and brain-derived neurotrophic factor (BDNF) in healthy individuals. We hypothesized that a KD would increase CBF and BDNF, thereby presenting itself as an approach to prevent cognitive decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In total, 11 cognitively healthy individuals with overweight participated in a randomized, crossover trial consisting of 2 different 3-week interventions: (i) a KD; and (ii) a standard diet (SDD). Each diet period concluded with a positron emission tomography (PET) study day, accompanied by a separate magnetic resonance imaging (MRI) scan. Blood samples were collected prior to the PET scan to measure \u03b2-hydroxybutyrate (\u03b2-OHB) and BDNF levels. CBF was assessed using a [15O]H2O PET scan co-registered with an MRI scan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A KD led to increased basal plasma \u03b2-OHB levels compared to the SDD (647 [418-724] vs 50 [50-60] \u03bcmol\/L, P &amp;lt; .05), increased CBF by 22% (P = .02), and elevated BDNF levels by 47% (P = .04). Moreover, a correlation was observed between \u03b2-OHB levels and CBF measurements across the 2 diets (R2 = 0.54, P &amp;lt; .001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Implementing a KD improved CBF and raised BDNF levels in cognitively healthy individuals, indicating that a KD should be assessed for as a potential treatment for conditions associated with reduced CBF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf207","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T07:47:55Z","timestamp":1743493675000},"page":"e4176-e4181","source":"Crossref","is-referenced-by-count":8,"title":["A 3-Week Ketogenic Diet Increases Global Cerebral Blood Flow and Brain-Derived Neurotrophic 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