{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:12:22Z","timestamp":1790611942397,"version":"4.1.0"},"reference-count":36,"publisher":"The Endocrine Society","issue":"12","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Congenital hypogonadotropic hypogonadism (CHH) in infant boys is a rare disorder that can manifest as micropenis and\/or cryptorchidism. Mini-puberty is considered a window of opportunity for CHH diagnosis and treatment. The lack of testosterone (T) elevation during this period is the gold standard for CHH diagnosis, but hormonal evaluation is not always available at this time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim was to compare inhibin B (INHB), anti-M\u00fcllerian hormone (AMH), T, LH, and FSH between infant boys (1 to 365 days) with micropenis and\/or cryptorchidism due to isolated CHH (iCHH), CHH as part of combined pituitary hormone deficiency (CPHD), or of idiopathic origin (controls) and to determine discriminating cutoffs for CHH diagnosis based on sensitivity (Se) and specificity (Sp).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter study from 7 University Hospitals in France included 138 boys aged 0 to 12 months (58 with iCHH, including 28 with a positive molecular diagnosis, 32 with CPHD, and 48 controls). Four periods of interest were studied: between 1 to 4 days, 15 to 65 days (early mini-puberty, corresponding to the T peak), 66 to 179 days (late mini-puberty), and 180 to 365 days (post mini-puberty).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of mini-puberty, the best-discriminating hormones were INHB between 1 to 4 days (Se\/Sp 100%\/75% at 150\u2005pg\/mL and 89%\/100% at 85\u2005pg\/mL) and INHB and AMH after 180 days (INHB: Se\/Sp 100%\/100% at 100\u2005pg\/mL; AMH: Se\/Sp 100%\/92% at 600\u2005pmol\/L, and 75%\/100% at 370\u2005pmol\/L). INHB and\/or AMH discriminating performances were good (area under the receiver operating characteristic curve \u2265 0.95) across all 4 periods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Inhibin B and\/or AMH can be used to diagnose CHH in boys &amp;lt; 1 year of age.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf219","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T20:41:48Z","timestamp":1744058508000},"page":"e4119-e4128","source":"Crossref","is-referenced-by-count":4,"title":["Inhibin B and AMH for Diagnosis of Hypogonadotropic Hypogonadism in Boys Under 1 Year of Age: A Case-control Study"],"prefix":"10.1210","volume":"110","author":[{"given":"Tifenn","family":"Gueguen","sequence":"first","affiliation":[{"name":"Department of Pediatric Endocrinology, University Hospital , Angers 49100 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Pediatric Endocrinology, University Hospital , Angers 49100 ,","place":["France"]},{"name":"Reference Center for Rare Pituitary Diseases, CHU Angers , Angers 49100 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Avril","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology Department, CHU Robert Debr\u00e9, Assistance Publique-H\u00f4pitaux de Paris , Paris 75019 ,","place":["France"]},{"name":"Reference Center for Rare Disease CRMR de la Croissance et du D\u00e9veloppement, CHU Robert Debr\u00e9 , Paris 75019 ,","place":["France"]},{"name":"Universit\u00e9 Paris Cit\u00e9 , Paris 75013 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Simon","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology Department, CHU Robert Debr\u00e9, Assistance Publique-H\u00f4pitaux de Paris , Paris 75019 ,","place":["France"]},{"name":"Reference Center for Rare Disease CRMR de la Croissance et du D\u00e9veloppement, CHU Robert Debr\u00e9 , Paris 75019 ,","place":["France"]},{"name":"Universit\u00e9 Paris Cit\u00e9 , Paris 75013 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"de Kerdanet","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, University Hospital , Rennes 35000 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1365-6466","authenticated-orcid":false,"given":"Najiba","family":"Lahlou","sequence":"additional","affiliation":[{"name":"Department of Hormonology, BPR Specialized Analyses , Pannes 45700 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Baron","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, University Hospital , Nantes 44000 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