{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:25:43Z","timestamp":1790267143025,"version":"4.1.0"},"reference-count":28,"publisher":"The Endocrine Society","issue":"12","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Short-statured midpubertal boys with predicted adult height (PAHt) below the third percentile are a therapeutic challenge. Aromatase inhibitors (AI) delay estrogen-driven epiphyseal fusion and possibly enhance adult height (AHt).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the efficacy of AI treatment on AHt in midpubertal boys with a short PAHt due to advanced bone age (BA) or idiopathic short stature (ISS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Tertiary pediatric endocrine referral center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Two groups of midpubertal boys treated with AI were studied: 27 boys with fast puberty compared to matched untreated controls and 16 boys with ISS treated with GH and AI (GH&amp;AI) compared to those treated with GH only. Anthropometric measurements, BA and PAHt, were tracked. AHt was compared across groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Achieved AHt in AI-treated boys vs controls and the PAHt.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median duration of AI treatment was 2.8 years for the AI-only group and 2 years for the GH&amp;AI group. Throughout treatment, AI-treated groups gained height similarly to controls and showed a decrease in BA SD score (AI only: P = .009; GH&amp;AI: P = .029) and an improvement in PAHt (AI only: P = .003; GH&amp;AI: P = .037). Compared to controls, AI-treated children achieved greater AHt (AI only: 166.6 \u00b1 3.1\u2005cm vs 163.4 \u00b1 1.3\u2005cm, P = .003; GH&amp;AI: 167.3 \u00b1 6.1\u2005cm vs 164.9 \u00b1 3.5\u2005cm, P = .194). The difference between AHt and PAHt at baseline was more pronounced in the AI-treated groups (AI only: 3.8 \u00b1 3.5\u2005cm vs \u22120.3 \u00b1 5.0\u2005cm, P = .001; GH&amp;AI: 7.5 \u00b1 5.2\u2005cm vs 4.3 \u00b1 3.6\u2005cm, P = .050).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AI treatment extends the growth period, resulting in an AHt surpassing initial predictions. Our findings underscore the potential of AI treatment in midpubertal boys with a short PAHt due to advanced BA and in those treated with GH for ISS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf224","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T22:08:28Z","timestamp":1744063708000},"page":"e4129-e4136","source":"Crossref","is-referenced-by-count":6,"title":["Aromatase Inhibitors Treatment Alone or With GH Increases Final Height in Short-statured Pubertal Boys\u2014Real-world Data"],"prefix":"10.1210","volume":"110","author":[{"given":"Michal","family":"Yackobovitch\u2013Gavan","sequence":"first","affiliation":[{"name":"The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, National Center for Childhood Diabetes, Schneider Children's Medical Center of Israel , Petach Tikva 49202 ,","place":["Israel"]},{"name":"Department of Epidemiology and Preventive Medicine, School of Public Health, Faculty of 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