{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T08:28:50Z","timestamp":1792052930177,"version":"4.4.0"},"reference-count":63,"publisher":"The Endocrine Society","issue":"12","license":[{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF20OC0065960"],"award-info":[{"award-number":["NNF20OC0065960"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Muscle mass and function are impaired in type 1 diabetes (T1D); however, the relevance to bone health is unknown. This study aimed to examine the relationship between muscle mass, muscle strength, and bone in adults with childhood onset of T1D.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study population includes 111 Danish men and women with T1D onset before age 18 years and 37 sex- and age-matched controls. Lean mass was assessed through dual-energy x-ray absorptiometry, and hand grip strength was measured using a dynamometer. Bone mineral density (BMD), bone size, and bone material strength index were assessed by dual-energy x-ray absorptiometry, high-resolution peripheral quantitative computed tomography, and microindentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Participants had a median age of 43.2 years and body mass index of 26.9\u2005kg\/m2, with no differences between groups. Total and appendicular lean mass were comparable in persons with and without T1D (P = .41 and P = .75), as was grip strength (P = .52). BMD, bone size (cortical area and perimeter), and bone material strength index did not differ between groups (P &amp;gt; .05). Within the T1D group, appendicular lean mass\/height2 was positively associated with femoral neck BMD (R2 = 0.12) and total hip BMD (R2 = 0.337). Similarly, grip strength was associated with femoral neck-BMD (R2 = 0.104), and total hip-BMD (R2 = 0.137). The associations between muscle indices and BMD measures did not differ significantly between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We observed a strong association between muscle and bone regardless of T1D status. Overall, the associations did not differ between the T1D and control groups, suggesting that the muscle-bone crosstalk is not affected by T1D.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf245","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T06:01:12Z","timestamp":1745388072000},"page":"e4011-e4022","source":"Crossref","is-referenced-by-count":2,"title":["Association Between Muscle Status and Bone Size, Density, and Strength in Type 1 Diabetes: A Cross-sectional Study"],"prefix":"10.1210","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1128-454X","authenticated-orcid":false,"given":"Inge Agnete Gerlach","family":"Brandt","sequence":"first","affiliation":[{"name":"Steno Diabetes Center North Denmark, Aalborg University , 9000 Aalborg ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, Aalborg University , 9000 Aalborg ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9046-2967","authenticated-orcid":false,"given":"Peter","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center North Denmark, Aalborg University , 9000 Aalborg ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8581-3523","authenticated-orcid":false,"given":"Torben","family":"Harsl\u00f8f","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine, Aarhus University Hospital , 8000 Aarhus ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4285-5459","authenticated-orcid":false,"given":"Claus Bogh","family":"Juhl","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University Hospital , 6700 Esbjerg ,","place":["Denmark"]},{"name":"Steno Diabetes Center Odense , 5000 Odense C ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3880-3058","authenticated-orcid":false,"given":"Nicklas H\u00f8jgaard-Hessellund","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center North Denmark, Aalborg University , 9000 Aalborg ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5608-1589","authenticated-orcid":false,"given":"Morten","family":"Frost","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Molecular Endocrinology Laboratory, University of Southern Denmark , 5230 Odense M 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