{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:12:33Z","timestamp":1788232353255,"version":"build-2803163510"},"reference-count":40,"publisher":"The Endocrine Society","issue":"12","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sociedad Espa\u00f1ola de Endocrinolog\u00eda y Nutrici\u00f3n"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>It has been proposed that the PANOMEN-3 classification may be useful to guide the prognosis and therapy of patients with pituitary tumors (PTs). However, the model has not yet been validated to date in order to assess its usefulness in routine clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of our study was to validate the classification proposed by the PANOMEN-3 group for the prediction of tumor recurrence\/progression in PTs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multicenter national case\u2013control study of patients with PTs followed for at least 5 years. Kaplan\u2013Meier curves were used to assess the time to tumor recurrence\/progression. Univariate and multivariate Cox regression analyses were used to estimate the hazard ratio (HR) and prognostic capacity of the classification proposed by the PANOMEN-3 group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1143 patients were included. Pituitary surgery was performed in 814 patients and the remaining 329 patients were followed with active surveillance or medical treatment. After a median follow-up of 8.8 years (5-29.8), 253 patients experienced tumor recurrence or biochemical\/radiological progression and were classified as cases. The other 890 patients were classified as controls. The mean follow-up from PT diagnosis to recurrence was 7.2 \u00b1 5.4 years. The diagnostic accuracy of the PANOMEN-3 model to predict recurrence\/progression was 75.6% (95% CI 0.716-0.796). Residual tumor (HR 2.20, P &amp;lt; .001), a hereditary syndrome (HR 5.15, P = .026), and active secretory status (HR 1.80, P = .021) were the most important variables in this model. Recurrence\/progression rate increased with increasing PANOMEN-3 grade (2.5% in grade 0; 10.3% in grade 1, 33.7% in grade 2, and 33.3% in grade 3; P &amp;lt; .001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The predictive model proposed by the PANOMEN-3 group may be useful to guide the prognosis and therapy of PTs in the Spanish population since it offers a good accuracy to predict tumoral\/biochemical recurrence and\/or progression in operated and nonoperated patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf252","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T06:49:15Z","timestamp":1745477355000},"page":"3391-3399","source":"Crossref","is-referenced-by-count":14,"title":["Validation and Limitations of the PANOMEN-3 Predictive Model for Tumor Recurrence and Progression in Pituitary Tumors"],"prefix":"10.1210","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0519-0072","authenticated-orcid":false,"given":"Marta","family":"Araujo-Castro","sequence":"first","affiliation":[{"name":"Department of Endocrinology & Nutrition, Hospital Universitario Ram\u00f3n y Cajal , 28034 Madrid ,","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica Ram\u00f3n y Cajal (IRYCIS) , 28034 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edelmiro","family":"Men\u00e9ndez Torre","sequence":"additional","affiliation":[{"name":"Department of Endocrinology & Nutrition, Hospital Universitario Central de Asturias , 33011 Asturias ,","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA) , 33011 Asturias ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Lozano-Aida","sequence":"additional","affiliation":[{"name":"Department of Endocrinology & Nutrition, Hospital Universitario Central de Asturias , 33011 Asturias ,","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA) , 33011 Asturias ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogelio","family":"Garc\u00eda-Centeno","sequence":"additional","affiliation":[{"name":"Department of Endocrinology & Nutrition, Hospital Universitario Gregorio Mara\u00f1\u00f3n , 28007 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Gonz\u00e1lez Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology & Nutrition, Hospital Universitario Gregorio Mara\u00f1\u00f3n , 28007 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Idrobo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology & Nutrition, Hospital Universitario Ram\u00f3n y Cajal , 28034 Madrid ,","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica Ram\u00f3n y Cajal (IRYCIS) , 28034 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estefan\u00eda","family":"Achote-Rea","sequence":"additional","affiliation":[{"name":"Department of Endocrinology & Nutrition, Hospital Universitario Ram\u00f3n y Cajal , 28034 Madrid ,","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica Ram\u00f3n y Cajal (IRYCIS) , 28034 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Irigaray Echarri","sequence":"additional","affiliation":[{"name":"Department of Endocrinology & Nutrition, Hospital Universitario Navarra , 28027 Pamplona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Dolores Moure","family":"Rodr\u00edguez-Argull\u00f3","sequence":"additional","affiliation":[{"name":"Department of Endocrinology & Nutrition, Hospital Universitario de Cruces , 48903 Bilbao ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Paja","sequence":"additional","affiliation":[{"name":"Department of Endocrinology & Nutrition, OSI Bilbao-Basurto, Hospital Universitario de Basurto , 48013 Bilbao ,","place":["Spain"]},{"name":"University of the Basque Country UPV\/EHU , 48013 Bilbao ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Guerrero-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology & Nutrition, Hospital Universitario de Bellvitge , Catalu\u00f1a L'Hospitalet de Llobregat, 08907 Barcelona \u00a0","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justo P","family":"Casta\u00f1o","sequence":"additional","affiliation":[{"name":"Maim\u00f3nides Biomedical Research Institute of C\u00f3rdoba (IMIBIC), University of Cordoba and Reina Sof\u00eda University Hospital , 14004 Cordoba ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Dolores Ollero Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Endocrinology & Nutrition, Hospital Universitario Navarra , 28027 Pamplona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Novo-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology & Nutrition, Hospital Universitario Virgen de las Nieves & Biosanitary Research Institute IBS Granada , 18014 Granada 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