{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:46:16Z","timestamp":1782276376217,"version":"3.54.5"},"reference-count":46,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2501600"],"award-info":[{"award-number":["2021YFC2501600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2501601"],"award-info":[{"award-number":["2021YFC2501601"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2501603"],"award-info":[{"award-number":["2021YFC2501603"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91857205"],"award-info":[{"award-number":["91857205"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400779"],"award-info":[{"award-number":["81400779"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014443","name":"Noncommunicable Chronic Diseases-National Science and Technology","doi-asserted-by":"publisher","award":["2023ZD0517900"],"award-info":[{"award-number":["2023ZD0517900"]}],"id":[{"id":"10.13039\/100014443","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010755","name":"Chinese Society of Endocrinology","doi-asserted-by":"publisher","award":["13050890474"],"award-info":[{"award-number":["13050890474"]}],"id":[{"id":"10.13039\/100010755","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013104","name":"Shanghai Medical and Health Development Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013104","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014137","name":"Shanghai Shenkang Hospital Development Center","doi-asserted-by":"publisher","award":["SHDC2020CR2002A"],"award-info":[{"award-number":["SHDC2020CR2002A"]}],"id":[{"id":"10.13039\/501100014137","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014137","name":"Shanghai Shenkang Hospital Development Center","doi-asserted-by":"publisher","award":["SHDC2020CR6015"],"award-info":[{"award-number":["SHDC2020CR6015"]}],"id":[{"id":"10.13039\/501100014137","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014175","name":"Shanghai Municipal Commission of Health and Family Planning","doi-asserted-by":"publisher","award":["201840049"],"award-info":[{"award-number":["201840049"]}],"id":[{"id":"10.13039\/501100014175","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>The ubiquitin-specific protease 8 (USP8) gene mutations are the most common driver changes in Cushing disease (CD). However, few studies have investigated the association between USP8 mutation and recurrence, and the results have been inconclusive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify the predictors of recurrence and evaluate the prognostic role of USP8 mutation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One hundred and seven patients with pathologically confirmed corticotroph adenomas were included. Somatic USP8 mutations were identified using Sanger sequencing. Recurrence predictors were estimated using multivariate Cox models, followed by receiver operating characteristic curves and Kaplan\u2013Meier analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirteen patients (12.6%) experienced recurrence, with a mean follow-up period of 65 months after surgery. The recurrence rate was significantly higher in USP8-mutated tumors than in USP8 wildtype tumors (26.5% vs 5.8%; P = .009). Multivariate Cox models revealed that USP8 mutation, high postsurgical morning serum cortisol (MSC), and high 1-mg dexamethasone suppression test (DST) were associated with an increased 5-year recurrence risk. Furthermore, Kaplan\u2013Meier survival analysis showed that patients with USP8 mutation, combined with either high postsurgical MSC (&amp;gt;2.5\u2005\u03bcg\/dL) or high 1-mg DST (&amp;gt;0.78\u2005\u03bcg\/dL), were more prone to recurrence (log-rank P &amp;lt; .001). The negative predictive values were 98% and 100%, while the positive predictive values improved from 33% to 55% and from 47% to 86%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study corroborates USP8 mutational status in combination with postsurgical MSC or 1-mg DST as independent predictors of long-term remission, highlighting their potential role in stratifying patients at risk for suboptimal outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf269","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T07:24:00Z","timestamp":1748244240000},"page":"e156-e165","source":"Crossref","is-referenced-by-count":7,"title":["The USP8 Mutational Status in Combination With Postsurgical Cortisol Levels for Predicting Recurrence of Cushing Disease"],"prefix":"10.1210","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2003-7743","authenticated-orcid":false,"given":"Weiwei","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]},{"name":"Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sichang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]},{"name":"Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]},{"name":"Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingwei","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]},{"name":"Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]},{"name":"Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]},{"name":"Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]},{"name":"Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luming","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]},{"name":"Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]},{"name":"Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6027-3084","authenticated-orcid":false,"given":"Weiqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]},{"name":"Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"issue":"5","key":"2025121807424320700_dgaf269-B1","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1210\/jc.2008-0125","article-title":"The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline","volume":"93","author":"Nieman","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"issue":"9996","key":"2025121807424320700_dgaf269-B2","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0140-6736(14)61375-1","article-title":"Cushing's syndrome","volume":"386","author":"Lacroix","year":"2015","journal-title":"Lancet"},{"issue":"12","key":"2025121807424320700_dgaf269-B3","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S2213-8587(21)00235-7","article-title":"Consensus on diagnosis and management of Cushing's disease: a guideline update","volume":"9","author":"Fleseriu","year":"2021","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"10418","key":"2025121807424320700_dgaf269-B4","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1016\/S0140-6736(23)01961-X","article-title":"Cushing's syndrome","volume":"402","author":"Gadelha","year":"2023","journal-title":"Lancet"},{"issue":"7","key":"2025121807424320700_dgaf269-B5","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1210\/jc.2007-2734","article-title":"Treatment of adrenocorticotropin-dependent Cushing's syndrome: a consensus statement","volume":"93","author":"Biller","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"2025121807424320700_dgaf269-B6","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1210\/jc.2015-1818","article-title":"Treatment of Cushing's syndrome: an endocrine society clinical practice guideline","volume":"100","author":"Nieman","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"2025121807424320700_dgaf269-B7","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/s41574-023-00868-7","article-title":"An individualized approach to the management of Cushing disease","volume":"19","author":"Fleseriu","year":"2023","journal-title":"Nat Rev Endocrinol"},{"issue":"5","key":"2025121807424320700_dgaf269-B8","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1007\/s11102-022-01226-y","article-title":"Cushing's disease: risk of recurrence following trans-sphenoidal surgery, timing and methods for evaluation","volume":"25","author":"Balomenaki","year":"2022","journal-title":"Pituitary"},{"issue":"1","key":"2025121807424320700_dgaf269-B9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/ng.3166","article-title":"Mutations in the deubiquitinase gene USP8 cause Cushing's disease","volume":"47","author":"Reincke","year":"2015","journal-title":"Nat Genet"},{"issue":"3","key":"2025121807424320700_dgaf269-B10","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/cr.2015.20","article-title":"Recurrent gain-of-function USP8 mutations in Cushing's disease","volume":"25","author":"Ma","year":"2015","journal-title":"Cell Res"},{"issue":"7","key":"2025121807424320700_dgaf269-B11","doi-asserted-by":"crossref","first-page":"E997","DOI":"10.1210\/jc.2015-1453","article-title":"The gene of the ubiquitin-specific protease 8 is frequently mutated in adenomas causing Cushing's disease","volume":"100","author":"Perez-Rivas","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2025121807424320700_dgaf269-B12","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1530\/EJE-15-0689","article-title":"The USP8 mutational status may predict drug susceptibility in corticotroph adenomas of Cushing's disease","volume":"174","author":"Hayashi","year":"2016","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"2025121807424320700_dgaf269-B13","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3390\/jcm10030375","article-title":"Differential microRNA expression in USP8-mutated and wild-type corticotroph pituitary tumors reflect the difference in protein ubiquitination processes","volume":"10","author":"Bujko","year":"2021","journal-title":"J Clin Med"},{"issue":"2","key":"2025121807424320700_dgaf269-B14","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/s12020-018-1776-0","article-title":"Clinical characteristics and surgical outcome in USP8-mutated human adrenocorticotropic hormone-secreting pituitary adenomas","volume":"63","author":"Losa","year":"2019","journal-title":"Endocrine"},{"key":"2025121807424320700_dgaf269-B15","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13802","article-title":"The USP8 mutational status may predict long-term remission in patients with Cushing's disease","author":"Albani","year":"2018","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"4","key":"2025121807424320700_dgaf269-B16","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s11102-019-00973-9","article-title":"Cushing's disease due to somatic USP8 mutations: a systematic review and meta-analysis","volume":"22","author":"Wanichi","year":"2019","journal-title":"Pituitary"},{"issue":"8","key":"2025121807424320700_dgaf269-B17","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1210\/jc.2017-00161","article-title":"Somatic USP8 gene mutations are a common cause of pediatric cushing disease","volume":"102","author":"Faucz","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2025121807424320700_dgaf269-B18","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1210\/js.2017-00364","article-title":"USP8 mutations in pituitary cushing adenomas-targeted analysis by next-generation sequencing","volume":"2","author":"Ballmann","year":"2018","journal-title":"J Endocr Soc"},{"issue":"6","key":"2025121807424320700_dgaf269-B19","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1530\/EJE-19-0194","article-title":"USP8 mutations in corticotroph adenomas determine a distinct gene expression profile irrespective of functional tumour status","volume":"181","author":"Bujko","year":"2019","journal-title":"Eur J Endocrinol"},{"issue":"7","key":"2025121807424320700_dgaf269-B20","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1210\/jc.2018-02564","article-title":"Impact of USP8 gene mutations on protein deregulation in cushing disease","volume":"104","author":"Weigand","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2025121807424320700_dgaf269-B21","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1530\/EC-20-0035","article-title":"SST5 expression and USP8 mutation in functioning and silent corticotroph pituitary tumors","volume":"9","author":"Castellnou","year":"2020","journal-title":"Endocr Connect"},{"issue":"1-2","key":"2025121807424320700_dgaf269-B22","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1159\/000500688","article-title":"Ubiquitin-specific protease 8 mutant corticotrope adenomas present unique secretory and molecular features and shed light on the role of ubiquitylation on ACTH processing","volume":"110","author":"Sesta","year":"2020","journal-title":"Neuroendocrinology"},{"issue":"8","key":"2025121807424320700_dgaf269-B23","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1530\/ERC-22-0088","article-title":"Improved pasireotide response in USP8 mutant corticotroph tumours in vitro","volume":"29","author":"Albani","year":"2022","journal-title":"Endocr Relat Cancer"},{"issue":"1","key":"2025121807424320700_dgaf269-B24","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1038\/s41467-018-05275-5","article-title":"Identification of recurrent USP48 and BRAF mutations in Cushing's disease","volume":"9","author":"Chen","year":"2018","journal-title":"Nat Commun"},{"issue":"10","key":"2025121807424320700_dgaf269-B25","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1093\/neuonc\/noz109","article-title":"Driver mutations in USP8 wild-type Cushing's disease","volume":"21","author":"Sbiera","year":"2019","journal-title":"Neuro Oncol"},{"key":"2025121807424320700_dgaf269-B26","doi-asserted-by":"crossref","first-page":"1302667","DOI":"10.3389\/fendo.2024.1302667","article-title":"Relevance of mutations in protein deubiquitinases genes and TP53 in corticotroph pituitary tumors","volume":"15","author":"P\u0119kul","year":"2024","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"4","key":"2025121807424320700_dgaf269-B27","doi-asserted-by":"crossref","first-page":"M73","DOI":"10.1530\/EJE-15-0320","article-title":"Decoding the genetic basis of Cushing's disease: USP8 in the spotlight","volume":"173","author":"Theodoropoulou","year":"2015","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"2025121807424320700_dgaf269-B28","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ccell.2019.11.002","article-title":"Pangenomic classification of pituitary neuroendocrine tumors","volume":"37","author":"Neou","year":"2020","journal-title":"Cancer Cell"},{"issue":"2","key":"2025121807424320700_dgaf269-B29","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s12020-021-02903-x","article-title":"USP8, USP48, and BRAF mutations differ in their genotype-phenotype correlation in Asian Indian patients with Cushing's disease","volume":"75","author":"Abraham","year":"2020","journal-title":"Endocrine"},{"issue":"16","key":"2025121807424320700_dgaf269-B30","doi-asserted-by":"crossref","first-page":"4022","DOI":"10.3390\/cancers13164022","article-title":"Genetic profiling of a cohort of Italian patients with ACTH-secreting pituitary tumors and characterization of a novel USP8 gene variant","volume":"13","author":"Treppiedi","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"4","key":"2025121807424320700_dgaf269-B31","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00401-017-1769-8","article-title":"The 2017 World Health Organization classification of tumors of the pituitary gland: a summary","volume":"134","author":"Lopes","year":"2017","journal-title":"Acta Neuropathol"},{"issue":"1","key":"2025121807424320700_dgaf269-B32","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s12022-022-09703-7","article-title":"Overview of the 2022 WHO classification of pituitary tumors","volume":"33","author":"Asa","year":"2022","journal-title":"Endocr Pathol"},{"issue":"5","key":"2025121807424320700_dgaf269-B33","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41422-018-0019-5","article-title":"Pan-cancer analysis of somatic mutations across 21 neuroendocrine tumor types","volume":"28","author":"Cao","year":"2018","journal-title":"Cell Res"},{"key":"2025121807424320700_dgaf269-B34","doi-asserted-by":"crossref","unstructured":"Zhou W, Zheng S, Ye L, et al \u00a02025. Data from The USP8 Mutational Status in Combination with Postsurgical Cortisol Levels for Predicting Recurrence of Cushing Disease. Figshare. 10.6084\/m9.figshare.28815137.v1.","DOI":"10.1210\/clinem\/dgaf269"},{"issue":"1","key":"2025121807424320700_dgaf269-B35","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1530\/EJE-17-0634","article-title":"Somatic USP8 mutations are frequent events in corticotroph tumor progression causing Nelson's tumor","volume":"178","author":"P\u00e9rez-Rivas","year":"2018","journal-title":"Eur J Endocrinol"},{"issue":"9","key":"2025121807424320700_dgaf269-B36","doi-asserted-by":"crossref","first-page":"L73","DOI":"10.1530\/ERC-17-0054","article-title":"Expression and mutational status of USP8 in tumors causing ectopic ACTH secretion syndrome","volume":"24","author":"Perez-Rivas","year":"2017","journal-title":"Endocr Relat Cancer"},{"issue":"12","key":"2025121807424320700_dgaf269-B37","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1016\/j.gim.2022.08.021","article-title":"Genetic drivers of Cushing's disease: frequency and associated phenotypes","volume":"24","author":"Hern\u00e1ndez-Ram\u00edrez","year":"2022","journal-title":"Genet Med"},{"issue":"4","key":"2025121807424320700_dgaf269-B38","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1007\/s11102-012-0455-z","article-title":"Remission rate after transsphenoidal surgery in patients with pathologically confirmed Cushing's disease, the role of cortisol, ACTH assessment and immediate reoperation: a large single center experience","volume":"16","author":"Hameed","year":"2013","journal-title":"Pituitary"},{"issue":"2","key":"2025121807424320700_dgaf269-B39","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1530\/EJE-13-0634","article-title":"Long-term remission and recurrence rates after first and second transsphenoidal surgery for Cushing's disease: care reality in the Munich metropolitan region","volume":"170","author":"Dimopoulou","year":"2013","journal-title":"Eur J Endocrinol"},{"issue":"10","key":"2025121807424320700_dgaf269-B40","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1210\/jc.2015-2107","article-title":"Accuracy of late-night salivary cortisol in evaluating postoperative remission and recurrence in Cushing's disease","volume":"100","author":"Amlashi","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2025121807424320700_dgaf269-B41","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1530\/EJE-17-0873","article-title":"Earlier post-operative hypocortisolemia may predict durable remission from Cushing's disease","volume":"178","author":"Ironside","year":"2018","journal-title":"Eur J Endocrinol"},{"issue":"12","key":"2025121807424320700_dgaf269-B42","doi-asserted-by":"crossref","first-page":"5858","DOI":"10.1210\/jc.2003-030751","article-title":"Long-term predictive value of postsurgical cortisol concentrations for cure and risk of recurrence in Cushing's disease","volume":"88","author":"Pereira","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2025121807424320700_dgaf269-B43","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1210\/jc.2007-2013","article-title":"Late recurrences of Cushing's disease after initial successful transsphenoidal surgery","volume":"93","author":"Patil","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"2025121807424320700_dgaf269-B44","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.4158\/EP161380.OR","article-title":"Postsurgical recurrent Cushing disease: clinical benefit of early intervention in patients with normal urinary free cortisol","volume":"22","author":"Carroll","year":"2016","journal-title":"Endocr Pract"},{"key":"2025121807424320700_dgaf269-B45","doi-asserted-by":"crossref","first-page":"740","DOI":"10.3389\/fendo.2019.00740","article-title":"Hypercortisolemia recurrence in Cushing's disease; a diagnostic challenge","volume":"10","author":"Hinojosa-Amaya","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"9","key":"2025121807424320700_dgaf269-B46","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1111\/1753-0407.13432","article-title":"Association of glycemic gap with stroke recurrence in patients with ischemic stroke","volume":"15","author":"Yuan","year":"2023","journal-title":"J Diabetes"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgaf269\/63373437\/dgaf269.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/111\/1\/e156\/63373437\/dgaf269.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/111\/1\/e156\/63373437\/dgaf269.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T12:43:34Z","timestamp":1766061814000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/111\/1\/e156\/8151512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,27]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,5,27]]},"published-print":{"date-parts":[[2025,12,18]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgaf269","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,1]]},"published":{"date-parts":[[2025,5,27]]}}}