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All participants underwent an oral glucose tolerance test. Magnetic resonance imaging\u2013derived proton density fat fraction was used to measure fat content in different visceral organs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Pancreatic interlobular fat volume, pancreatic body fat, and hepatic fat were significantly higher in PCOS patients with diabetes than in those with normal glucose tolerance (P &amp;lt; .05). Elevated pancreatic body fat (OR 2.21 [95% CI 1.01-4.85], P = .047) and hepatic average fat (OR 2.92 [95% CI 1.13-7.51], P = .026) were independently associated with higher impaired glucose regulation (IGR) risks. Only patients with elevated levels of both pancreatic body fat and hepatic average fat exhibited increased risk of IGR after multiple confounding adjustments (OR 5.49 [95% CI 1.63-18.47], P = .006). The hepatic average fat to pancreatic body fat ratio lost its significant association with IGR risk after multivariable adjustment (P = .705). The combination of pancreatic body fat and hepatic average fat with traditional risk factors (age, body mass index, waist to hip circumference ratio, serum triglycerides, and free androgen index) demonstrated a trend toward improved predictive performance for IGR, with the highest area under the curve (0.789) observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pancreatic body and hepatic fat content predict IGR and synergistically regulate glucose metabolism in PCOS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf272","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T07:51:09Z","timestamp":1747036269000},"page":"e247-e259","source":"Crossref","is-referenced-by-count":3,"title":["Pancreatic Body and Hepatic Fat Content Predict Impaired Glucose Regulation in Women With Polycystic Ovary Syndrome"],"prefix":"10.1210","volume":"111","author":[{"given":"Chang","family":"Shan","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200127 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200127 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-chen","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200127 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1306-1676","authenticated-orcid":false,"given":"Jian","family":"Zhao","sequence":"additional","affiliation":[{"name":"Ministry of Education and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200092 ,","place":["China"]},{"name":"Department of Maternal and Child Health, School of Public Health, Shanghai Jiao Tong University , Shanghai 200092 ,","place":["China"]},{"name":"School of Public Health and Emergency Management, School of Medicine, Southern University of Science and Technology , Shenzhen, Guangdong 518055 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Shanghai East Hospital, Tongji University , Shanghai 200123 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-shan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200127 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-yu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200127 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200127 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