{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:48:06Z","timestamp":1792788486601,"version":"4.5.0"},"reference-count":40,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u00d8degaard and Frimann-Dahls","award":["11984"],"award-info":[{"award-number":["11984"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Ethanol ablation (EA) is a treatment option in recurrent or persistent metastatic lymph nodes (MLNs) from papillary thyroid carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This work aimed to assess whether ultrasonographic characteristics of the MLN, history of lymph node surgery, aggressive histological subtype, or BRAFV600E mutation in the primary tumor predict long-term response from EA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Seventy-five patients who received EA at a tertiary referral center were included. We evaluated treatment response from the most recent clinically indicated examination, or a study-specific examination. BRAFV600E analysis and review of histological subtypes in the primary tumor were conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median interval from initial surgery to follow-up was 119 months (range, 39-471 months). Pure cystic MLN had a better outcome than the solid and partially cystic MLN (13\/13, 100% vs 90\/121, 74%; P = .039). Small MLNs (\u22640.5\u2005mL) had a higher response rate compared to larger lesions (71\/92, 77% vs 10\/19, 53%; P = .045). We observed no difference in EA response between patients with or without the BRAFV600E mutation (80\/99, 81% vs 17\/25, 68%; P = .181) or an aggressive subtype (22\/24, 92% vs 75\/100, 75%; P = .099) in their primary tumors. EA achieved similar rates of locoregional disease control in neck regions with or without previous lymph node surgery (66% vs 63%, P = .825).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EA was highly effective in pure cystic MLNs. Partially cystic or noncystic MLNs over 0.5\u2005mL were less responsive, though many of these MLNs still showed a lasting response. BRAFV600E mutation, aggressive histological subtype, or absence of prior lymph node surgery did not negatively affect EA response.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf298","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T08:56:22Z","timestamp":1747817782000},"page":"e185-e194","source":"Crossref","is-referenced-by-count":2,"title":["Ethanol Ablation of Metastatic Lymph Nodes in Patients With Papillary Thyroid Carcinoma\u2014Predictors of Clinical Outcome"],"prefix":"10.1210","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8325-7332","authenticated-orcid":false,"given":"P\u00e5l Stefan","family":"Frich","sequence":"first","affiliation":[{"name":"Division of Radiology and Nuclear Medicine, Department of Radiology, The Norwegian Radium Hospital, Oslo University Hospital , 0424 Oslo ,","place":["Norway"]},{"name":"Institute of Clinical Medicine, Faculty of Medicine, University of Oslo , 0318 Oslo 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