{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T02:44:33Z","timestamp":1780109073617,"version":"3.54.0"},"reference-count":44,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFA0800801"],"award-info":[{"award-number":["2018YFA0800801"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100941"],"award-info":[{"award-number":["82100941"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300985"],"award-info":[{"award-number":["82300985"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974126"],"award-info":[{"award-number":["81974126"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200988"],"award-info":[{"award-number":["82200988"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M732309"],"award-info":[{"award-number":["2023M732309"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Paget disease of bone (PDB) is a metabolic disorder characterized by abnormal osteoclast activation. Recently, mutations in the PFN1 gene, which encodes Profilin 1, an actin-binding protein controlling actin dynamics and cell movement, have been linked to early-onset PDB. Interestingly, mutations in PFN1 (C71G, T109M, M114T, E117G, G118V, etc.) are associated with amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder affecting motor neurons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To provide insights into the underlying molecular mechanism of early-onset PDB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We observed the clinical responses to denosumab in early-onset PDB patients. Additionally, a mouse model carrying the c.335T&amp;gt;C mutation in the Pfn1 gene was generated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We reported a second Chinese family affected by early-onset PDB with malignant giant cell tumors, in which we identified the same heterozygous missense mutation (c.335T&amp;gt;C\/p. L112P) in PFN1 that we have reported previously in another family. Despite its proximity to ALS-linked PFN1 mutations, the PFN1 L112P mutation did not induce ALS in affected individuals. These early-onset PDB patients exhibited a significantly poorer response to denosumab compared to typical PDB patients. The heterozygous mice displayed PDB-like phenotypes, including skeletal deformities and focal osteoclastic lesions with giant osteoclasts, and did not show ALS-like phenotypes. We further show that mutation of Pfn1 leads to enhanced actin ring-like structures at the bone surfaces without affecting nuclear factor-\u03baB activation in osteoclast cultures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The observation of recurrent mutations highlights the causative role of PFN1 (L112P) in early-onset PDB\/giant cell tumor within the Chinese population and provides insights into the physio-pathological functions of Profilin 1.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf314","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T07:21:54Z","timestamp":1748848914000},"page":"93-106","source":"Crossref","is-referenced-by-count":1,"title":["A Missense Mutation in Close Proximity of ALS-linked\n                    <i>PFN1<\/i>\n                    Mutations Causes Only Early-onset Paget Disease of Bone"],"prefix":"10.1210","volume":"111","author":[{"given":"Rou","family":"Weng","sequence":"first","affiliation":[{"name":"Department of Osteoporosis and Bone Disease, Shanghai Clinical Research Center of Bone Disease, Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200233 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Surgery, Tangdu Hospital, The Fourth Military Medical University , Xi\u2019an, Shaanxi 710038 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Osteoporosis and Bone Disease, Shanghai Clinical Research Center of Bone Disease, Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200233 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Osteoporosis and Bone Disease, Shanghai Clinical Research Center of Bone Disease, Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200233 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Osteoporosis and Bone Disease, Shanghai Clinical Research Center of Bone Disease, Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200233 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Osteoporosis and Bone Disease, Shanghai Clinical Research Center of Bone Disease, Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200233 ,","place":["China"]},{"name":"Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University , Shanghai 200240 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baojie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Osteoporosis and Bone Disease, Shanghai Clinical Research Center of Bone Disease, Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200233 ,","place":["China"]},{"name":"Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University , Shanghai 200240 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4339-1617","authenticated-orcid":false,"given":"Zhenlin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Osteoporosis and Bone Disease, Shanghai Clinical Research Center of Bone Disease, Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200233 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"issue":"12","key":"2025121807420708000_dgaf314-B1","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1093\/rheumatology\/kew430","article-title":"Adult Paget's disease of bone: a review","volume":"56","author":"Paul Tuck","year":"2017","journal-title":"Rheumatology"},{"issue":"5","key":"2025121807420708000_dgaf314-B2","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s00223-019-00522-3","article-title":"Paget's disease of bone","volume":"104","author":"Gennari","year":"2019","journal-title":"Calcif Tissue Int"},{"issue":"S2","key":"2025121807420708000_dgaf314-B3","doi-asserted-by":"crossref","first-page":"P58","DOI":"10.1359\/jbmr.06s211","article-title":"Osteosarcoma in Paget's disease of bone","volume":"21","author":"Hansen","year":"2006","journal-title":"J Bone Miner Res"},{"issue":"3","key":"2025121807420708000_dgaf314-B4","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.bone.2008.11.002","article-title":"Sarcoma arising in Paget's disease of bone: declining incidence and increasing age at presentation","volume":"44","author":"Mangham","year":"2009","journal-title":"Bone"},{"issue":"2","key":"2025121807420708000_dgaf314-B5","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/jbmr.2349","article-title":"Clinical characteristics and evolution of giant cell tumor occurring in Paget's disease of bone","volume":"30","author":"Rendina","year":"2015","journal-title":"J Bone Miner Res"},{"key":"2025121807420708000_dgaf314-B6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2020.05.031","article-title":"The two faces of giant cell tumor of bone","volume":"489","author":"Scotto di Carlo","year":"2020","journal-title":"Cancer Lett"},{"key":"2025121807420708000_dgaf314-B7","doi-asserted-by":"crossref","first-page":"932065","DOI":"10.3389\/fcell.2022.932065","article-title":"Update on the pathogenesis and genetics of Paget's disease of bone","volume":"10","author":"Gennari","year":"2022","journal-title":"Front Cell Dev Biol"},{"issue":"S2","key":"2025121807420708000_dgaf314-B8","doi-asserted-by":"crossref","first-page":"P38","DOI":"10.1359\/jbmr.06s207","article-title":"Sequestosome 1: mutation frequencies, haplotypes, and phenotypes in familial Paget's disease of bone","volume":"21","author":"Morissette","year":"2006","journal-title":"J Bone Miner Res"},{"issue":"22","key":"2025121807420708000_dgaf314-B9","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1093\/hmg\/11.22.2735","article-title":"Domain-specific mutations in sequestosome 1 (SQSTM1) cause familial and sporadic Paget's disease","volume":"11","author":"Hocking","year":"2002","journal-title":"Hum Mol Genet"},{"key":"2025121807420708000_dgaf314-B10","doi-asserted-by":"crossref","first-page":"115224","DOI":"10.1016\/j.bone.2020.115224","article-title":"Early-onset Paget's disease of bone in a Mexican family caused by a novel tandem duplication (77dup27) in TNFRSF11A that encodes RANK","volume":"133","author":"Iwamoto","year":"2020","journal-title":"Bone"},{"issue":"4","key":"2025121807420708000_dgaf314-B11","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/ng1332","article-title":"Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein","volume":"36","author":"Watts","year":"2004","journal-title":"Nat Genet"},{"issue":"2","key":"2025121807420708000_dgaf314-B12","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ajhg.2015.12.016","article-title":"ZNF687 mutations in severe Paget disease of bone associated with giant cell tumor","volume":"98","author":"Divisato","year":"2016","journal-title":"Am J Hum Genet"},{"issue":"1-2","key":"2025121807420708000_dgaf314-B13","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jns.2009.12.008","article-title":"Late-onset autosomal dominant limb girdle muscular dystrophy and Paget's disease of bone unlinked to the VCP gene locus","volume":"291","author":"Kottlors","year":"2010","journal-title":"J Neurol Sci"},{"issue":"7442","key":"2025121807420708000_dgaf314-B14","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nature11922","article-title":"Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS","volume":"495","author":"Kim","year":"2013","journal-title":"Nature"},{"issue":"8","key":"2025121807420708000_dgaf314-B15","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1210\/clinem\/dgaa252","article-title":"Mutation of PFN1 gene in an early onset, polyostotic Paget-like disease","volume":"105","author":"Merlotti","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"2025121807420708000_dgaf314-B16","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1002\/jbmr.3964","article-title":"The loss of profilin 1 causes early onset Paget's disease of bone","volume":"35","author":"Scotto di Carlo","year":"2020","journal-title":"J Bone Miner Res"},{"issue":"6","key":"2025121807420708000_dgaf314-B17","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1002\/jbmr.4275","article-title":"Mutations in profilin 1 cause early-onset Paget's disease of bone with giant cell tumors","volume":"36","author":"Wei","year":"2021","journal-title":"J Bone Miner Res"},{"issue":"6","key":"2025121807420708000_dgaf314-B18","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s00018-016-2372-1","article-title":"Profilin1 biology and its mutation, actin(g) in disease","volume":"74","author":"Alkam","year":"2017","journal-title":"Cell Mol Life Sci"},{"issue":"8","key":"2025121807420708000_dgaf314-B19","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.tcb.2004.07.003","article-title":"The role of profilin complexes in cell motility and other cellular processes","volume":"14","author":"Witke","year":"2004","journal-title":"Trends Cell Biol"},{"issue":"6","key":"2025121807420708000_dgaf314-B20","doi-asserted-by":"crossref","first-page":"4620","DOI":"10.1016\/S0021-9258(17)41821-7","article-title":"Identification of the poly-L-proline-binding site on human profilin","volume":"269","author":"Metzler","year":"1994","journal-title":"J Biol Chem"},{"issue":"6449","key":"2025121807420708000_dgaf314-B21","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/365810a0","article-title":"The structure of crystalline profilin-beta-actin","volume":"365","author":"Schutt","year":"1993","journal-title":"Nature"},{"issue":"1","key":"2025121807420708000_dgaf314-B22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/nn.3584","article-title":"State of play in amyotrophic lateral sclerosis genetics","volume":"17","author":"Renton","year":"2014","journal-title":"Nat Neurosci"},{"issue":"7412","key":"2025121807420708000_dgaf314-B23","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nature11280","article-title":"Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis","volume":"488","author":"Wu","year":"2012","journal-title":"Nature"},{"issue":"2","key":"2025121807420708000_dgaf314-B24","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1046\/j.0009-9163.2002.00001.x","article-title":"Genetic epidemiology of amyotrophic lateral sclerosis","volume":"63","author":"Majoor-Krakauer","year":"2003","journal-title":"Clin Genet"},{"issue":"7","key":"2025121807420708000_dgaf314-B25","doi-asserted-by":"crossref","first-page":"1922.e1","DOI":"10.1016\/j.neurobiolaging.2013.01.013","article-title":"PFN1 mutations are rare in Han Chinese populations with amyotrophic lateral sclerosis","volume":"34","author":"Chen","year":"2013","journal-title":"Neurobiol Aging"},{"issue":"6","key":"2025121807420708000_dgaf314-B26","doi-asserted-by":"crossref","first-page":"1708.e1","DOI":"10.1016\/j.neurobiolaging.2012.10.009","article-title":"A novel phosphorylation site mutation in profilin 1 revealed in a large screen of US, Nordic, and German amyotrophic lateral sclerosis\/frontotemporal dementia cohorts","volume":"34","author":"Ingre","year":"2013","journal-title":"Neurobiol Aging"},{"issue":"3","key":"2025121807420708000_dgaf314-B27","doi-asserted-by":"crossref","first-page":"1602.e17","DOI":"10.1016\/j.neurobiolaging.2014.10.032","article-title":"Novel mutations support a role for Profilin 1 in the pathogenesis of ALS","volume":"36","author":"Smith","year":"2015","journal-title":"Neurobiol Aging"},{"issue":"12","key":"2025121807420708000_dgaf314-B28","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1084\/jem.20111313","article-title":"Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor \u03baB-mediated pathogenic pathways","volume":"208","author":"Swarup","year":"2011","journal-title":"J Exp Med"},{"issue":"3","key":"2025121807420708000_dgaf314-B29","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.cell.2020.09.020","article-title":"TDP-43 Triggers mitochondrial DNA release via mPTP to activate cGAS\/STING in ALS","volume":"183","author":"Yu","year":"2020","journal-title":"Cell"},{"issue":"8","key":"2025121807420708000_dgaf314-B30","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.ajpath.2023.04.008","article-title":"Profilin1 regulates trophoblast invasion and macrophage differentiation","volume":"193","author":"Chen","year":"2023","journal-title":"Am J Pathol"},{"issue":"7","key":"2025121807420708000_dgaf314-B31","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1042\/BJ20150624","article-title":"Profilin-PTEN interaction suppresses NF-\u03baB activation via inhibition of IKK phosphorylation","volume":"473","author":"Zaidi","year":"2016","journal-title":"Biochem J"},{"issue":"1","key":"2025121807420708000_dgaf314-B32","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1038\/s41467-024-46695-w","article-title":"Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia","volume":"15","author":"Funes","year":"2024","journal-title":"Nat Commun"},{"key":"2025121807420708000_dgaf314-B33","unstructured":"Weng R, Li XX, Zhang ZL, et al \u00a0Data from: A missense mutation in close proximity of ALS-linked PFN1 mutations causes only early-onset Paget's disease of bone. Supplementary information. figshare. 10.6084\/m9.figshare.29094674.v1"},{"issue":"6","key":"2025121807420708000_dgaf314-B34","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/j.stemcr.2017.04.005","article-title":"Bone size and quality regulation: concerted actions of mTOR in mesenchymal stromal cells and osteoclasts","volume":"8","author":"Wu","year":"2017","journal-title":"Stem Cell Reports"},{"issue":"26","key":"2025121807420708000_dgaf314-B35","doi-asserted-by":"crossref","first-page":"7984","DOI":"10.1073\/pnas.1424108112","article-title":"Structural basis for mutation-induced destabilization of profilin 1 in ALS","volume":"112","author":"Boopathy","year":"30 2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"2025121807420708000_dgaf314-B36","doi-asserted-by":"crossref","first-page":"e10130","DOI":"10.1002\/jbm4.10130","article-title":"Profilin 1 negatively regulates osteoclast migration in postnatal skeletal growth, remodeling, and homeostasis in mice","volume":"3","author":"Shirakawa","year":"2019","journal-title":"JBMR Plus"},{"issue":"10","key":"2025121807420708000_dgaf314-B37","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1002\/bies.20822","article-title":"Profilin, a multi-modal regulator of neuronal plasticity","volume":"30","author":"Birbach","year":"2008","journal-title":"Bioessays"},{"issue":"3","key":"2025121807420708000_dgaf314-B38","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/0022-2836(77)90166-8","article-title":"Actin polymerizability is influenced by profilin, a low molecular weight protein in non-muscle cells","volume":"115","author":"Carlsson","year":"1977","journal-title":"J Mol Biol"},{"issue":"6010","key":"2025121807420708000_dgaf314-B39","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/314472a0","article-title":"Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilactin","volume":"314","author":"Lassing","year":"1985","journal-title":"Nature"},{"issue":"4","key":"2025121807420708000_dgaf314-B40","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1074\/jbc.M805280200","article-title":"Cathepsin K activity-dependent regulation of osteoclast actin ring formation and bone resorption","volume":"284","author":"Wilson","year":"2009","journal-title":"J Biol Chem"},{"issue":"12","key":"2025121807420708000_dgaf314-B41","first-page":"Cd004956","article-title":"Bisphosphonates for Paget's disease of bone in adults","volume":"12","author":"Corral-Gudino","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"issue":"9","key":"2025121807420708000_dgaf314-B42","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1056\/NEJMoa044241","article-title":"Comparison of a single infusion of zoledronic acid with risedronate for Paget's disease","volume":"353","author":"Reid","year":"2005","journal-title":"N Engl J Med"},{"issue":"3","key":"2025121807420708000_dgaf314-B43","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/s00223-016-0150-6","article-title":"Treatment of Paget's disease of bone with denosumab: case report and literature review","volume":"99","author":"Reid","year":"2016","journal-title":"Calcif Tissue Int"},{"issue":"5","key":"2025121807420708000_dgaf314-B44","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.bone.2012.01.020","article-title":"Paget's disease of the bone after treatment with denosumab: a case report","volume":"50","author":"Schwarz","year":"2012","journal-title":"Bone"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgaf314\/63422165\/dgaf314.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/111\/1\/93\/63422165\/dgaf314.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/111\/1\/93\/63422165\/dgaf314.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T12:42:35Z","timestamp":1766061755000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/111\/1\/93\/8155654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,3]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,6,3]]},"published-print":{"date-parts":[[2025,12,18]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgaf314","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,1]]},"published":{"date-parts":[[2025,6,3]]}}}