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Participants included 15 people with overweight\/obesity (body mass index [BMI] 32.5 [31-34] kg\/m2, median [IQR]). There were 3 dietary interventions: (1) 2 days of isocaloric control diet (CON), (2) 2 days of CON followed by 2 days of carbohydrate restriction (\u223c60\u2005g\/day) during very-low\u2013calorie conditions (VLCDs), and (3) 2 days of CON followed by 2 days of isocaloric conditions with low carbohydrate (\u223c60\u2005g\/day), high-fat (LCHF) diet. Liver fat was measured using 1H-magnetic resonance spectroscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Liver fat was \u221216% (\u221234; 4) (median [IQR]) after LCHF relative to after CON (P = .020), but did not differ between VLCD and CON. Fasting plasma concentrations of triacylglycerol, glucose, and insulin were lower after both LCHF and VLCD than after CON. However, postprandial plasma glucose concentrations were higher and insulinogenic index lower after both LCHF and VLCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Two days of LCHF led to lower liver fat, which was not observed after VLCD. This demonstrates the dynamic regulation of liver fat and the beneficial role of substituting carbohydrates with fat to maintain energy provision. Both LCHF and VLCD had positive effects on fasting parameters for glucose metabolism; however, both diets impaired early \u03b2-cell response resulting in deterioration in glucose handling during the meal test.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf382","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T08:04:33Z","timestamp":1751443473000},"page":"449-460","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Acute Iso- and Hypocaloric Carbohydrate Restriction on Liver Fat and Glucose and Lipid Metabolism"],"prefix":"10.1210","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1708-9809","authenticated-orcid":false,"given":"Amalie","family":"London","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Copenhagen University Hospital Hvidovre , Hvidovre 2650 ,","place":["Denmark"]},{"name":"Department of Nutrition, Exercise and Sports, The August Krogh Section for Human and 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Copenhagen University Hospital Hvidovre , Hvidovre 2650 ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen 2200 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartwig Roman","family":"Siebner","sequence":"additional","affiliation":[{"name":"Danish Research Centre for Magnetic Resonance (DRCMR), Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre , Hvidovre 2650 ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen 2200 ,","place":["Denmark"]},{"name":"Department of Neurology, Copenhagen University Hospital Bispebjerg and Frederiksberg , Copenhagen 2200 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