{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:07:33Z","timestamp":1787663253379,"version":"build-2736575974"},"reference-count":121,"publisher":"The Endocrine Society","issue":"11","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Available prenatal and postnatal tests for obtaining a molecular genetic diagnosis for differences of sexual development (DSD) have largely expanded over the last decade. More importantly, the medical management of these conditions has taken a different approach, with greater emphasis on patient autonomy, holistic care, and psychosocial support. These changes are illustrated through the discussion of 2 cases with a common form of DSD. While the principles and recommendations for the diagnosis and medical management of DSD are universal in nature, they need to be translated into clinical care pathways that align with the specific sociocultural background of patients and their caregivers to ensure the best possible outcome. Considering the inherent global differences in the organization and accessibility of health care and available resources, this requires an individualized approach based on shared decision-making and clinical guidelines that are in line with local facilities and societal context.<\/jats:p>","DOI":"10.1210\/clinem\/dgaf386","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T08:04:32Z","timestamp":1751443472000},"page":"3264-3277","source":"Crossref","is-referenced-by-count":6,"title":["Approach to the Patient With a Difference of Sexual Development"],"prefix":"10.1210","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0914-2676","authenticated-orcid":false,"given":"Hannes","family":"Syryn","sequence":"first","affiliation":[{"name":"Department of Biomolecular Medicine, Ghent University , 9000 Ghent ,","place":["Belgium"]},{"name":"Center for Medical Genetics, Ghent University Hospital , 9000 Ghent ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5609-6895","authenticated-orcid":false,"given":"Elfride","family":"De Baere","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Medicine, Ghent University , 9000 Ghent ,","place":["Belgium"]},{"name":"Center for Medical Genetics, Ghent University Hospital , 9000 Ghent ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9552-4899","authenticated-orcid":false,"given":"Martine","family":"Cools","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Pediatrics, Ghent University , 9000 Ghent ,","place":["Belgium"]},{"name":"Division of Pediatric Endocrinology, Department of Pediatrics, Ghent University Hospital , Ghent 9000 ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"issue":"7","key":"2025101519585785000_dgaf386-B1","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41585-023-00754-x","article-title":"Genetic control of typical and atypical sex development","volume":"20","author":"Reyes","year":"2023","journal-title":"Nat Rev Urol"},{"issue":"7","key":"2025101519585785000_dgaf386-B2","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1136\/adc.2006.098319","article-title":"Consensus statement on management of intersex disorders","volume":"91","author":"Hughes","year":"2006","journal-title":"Arch Dis Child"},{"issue":"2","key":"2025101519585785000_dgaf386-B3","first-page":"226","article-title":"Multi-stakeholder opinion statement on the care of individuals born with differences of sex development: common ground and opportunities for improvement","volume":"98","author":"Cools","year":"2024","journal-title":"Horm Res Paediatr"},{"issue":"4","key":"2025101519585785000_dgaf386-B4","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1080\/00224499.2019.1703130","article-title":"Disorders or differences of sex development? 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