{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:45:47Z","timestamp":1769042747546,"version":"3.49.0"},"reference-count":48,"publisher":"The Endocrine Society","issue":"2","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Short Synacthen testing (SST) is resource intensive and may be unnecessary if adrenal sufficiency (AS) can be predicted reliably using basal cortisol (BC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This work aimed to identify the BC threshold predictive of AS and evaluate the utility of 30- and 60-minute stimulated cortisol measurements in response to SST.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This research took place at a public tertiary pathology service (PathWest) in Western Australia. Of 1216 SSTs performed, 704 adult results were eligible. Exclusions were based on incomplete data or protocol deviations. Intervention was intramuscular Synacthen 250 mcg with cortisol measured at baseline, 30, and 60 minutes. AS was defined as serum cortisol greater than 430\u2005nmol\/L at 30 minutes and\/or greater than 500\u2005nmol\/L at 60 minutes. Receiver operating characteristic analysis identified BC thresholds predicting AS with 95% specificity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 704 SSTs included, 571 (81%) demonstrated AS. BC of 335\u2005nmol\/L or greater predicted AS at either 30 or 60 minutes. In a subgroup with pituitary pathology, a lower threshold of 240\u2005nmol\/L or greater maintained 95% specificity. For samples collected after 0945\u2005hours, BC of 251\u2005nmol\/L or greater predicted AS. Applying these thresholds could have avoided 31.1% of SSTs. Nineteen patients (2.7%) passed SST solely at the 60-minute cortisol result with median cortisol of 420\u2005nmol\/L.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>BC reliably predicts AS, avoiding unnecessary SST in a substantial number of patients. Adjusted thresholds for pituitary pathology and by time of day can enhance accuracy. Both 30- and 60-minute poststimulation cortisol identified a small group who would have failed SST using a single poststimulation measurement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf424","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T11:54:49Z","timestamp":1753271689000},"page":"e398-e405","source":"Crossref","is-referenced-by-count":1,"title":["Basal Cortisol as a Predictor of Passing Short Synacthen Test and the Utility of the 60-Minute Poststimulation Cortisol"],"prefix":"10.1210","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8257-3918","authenticated-orcid":false,"given":"James D","family":"Nolan","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital , Nedlands, Perth, WA 6009 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8413-561X","authenticated-orcid":false,"given":"Suzanne J","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital , Nedlands, Perth, WA 6009 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E","family":"Henley","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital , Nedlands, Perth, WA 6009 ,","place":["Australia"]},{"name":"Medical School, The University of Western Australia , Crawley, Perth, WA 6009 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ee Mun","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital , Nedlands, Perth, WA 6009 ,","place":["Australia"]},{"name":"Department of Clinical Biochemistry, PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre , Nedlands, Perth, WA 6009 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"issue":"6","key":"2026012101525305800_dgaf424-B1","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1530\/EJE-15-1187","article-title":"Low-dose hydrocortisone replacement is associated with improved arterial stiffness index and blood pressure dynamics in severely adrenocorticotrophin-deficient hypopituitary male patients","volume":"174","author":"Behan","year":"2016","journal-title":"Eur J Endocrinol"},{"issue":"11","key":"2026012101525305800_dgaf424-B2","doi-asserted-by":"crossref","first-page":"4216","DOI":"10.1210\/jc.2009-1097","article-title":"ACTH deficiency, higher doses of hydrocortisone replacement, and radiotherapy are independent predictors of mortality in patients with acromegaly","volume":"94","author":"Sherlock","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"2026012101525305800_dgaf424-B3","doi-asserted-by":"crossref","first-page":"E1938","DOI":"10.1210\/jc.2012-2432","article-title":"Glucocorticoid replacement and mortality in patients with nonfunctioning pituitary adenoma","volume":"97","author":"Zueger","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2026012101525305800_dgaf424-B4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/cen.15074","article-title":"Redefining ITT cortisol thresholds on Abbott platforms to prevent misdiagnosis of adrenal insufficiency","volume":"101","author":"Lazarus","year":"2024","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"2","key":"2026012101525305800_dgaf424-B5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1046\/j.1365-2265.1996.555381.x","article-title":"The short Synacthen and insulin stress tests in the assessment of the hypothalamic-pituitary-adrenal axis","volume":"44","author":"Hurel","year":"1996","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"3","key":"2026012101525305800_dgaf424-B6","first-page":"838","article-title":"Comparison of the low dose short Synacthen test (1 microg), the conventional dose short Synacthen test (250 microg), and the insulin tolerance test for assessment of the hypothalamo-pituitary-adrenal axis in patients with pituitary disease","volume":"84","author":"Abdu","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2026012101525305800_dgaf424-B7","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1210\/jc.2015-1710","article-title":"Diagnosis and treatment of primary adrenal insufficiency: an Endocrine Society clinical practice guideline","volume":"101","author":"Bornstein","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"2026012101525305800_dgaf424-B8","doi-asserted-by":"crossref","first-page":"3888","DOI":"10.1210\/jc.2016-2118","article-title":"Hormonal replacement in hypopituitarism in adults: an Endocrine Society clinical practice guideline","volume":"101","author":"Fleseriu","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"2026012101525305800_dgaf424-B9","doi-asserted-by":"crossref","first-page":"bvab147","DOI":"10.1210\/jendso\/bvab147","article-title":"Improving the interpretation of afternoon cortisol levels and SSTs to prevent misdiagnosis of adrenal insufficiency","volume":"5","author":"Ramadoss","year":"2021","journal-title":"J Endocr Soc"},{"issue":"1","key":"2026012101525305800_dgaf424-B10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/cen.12373","article-title":"How good is a morning cortisol in predicting an adequate response to intramuscular Synacthen stimulation?","volume":"81","author":"Yo","year":"2014","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"7","key":"2026012101525305800_dgaf424-B11","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.eprac.2022.04.003","article-title":"New diagnostic cutoffs for adrenal insufficiency after cosyntropin stimulation using Abbott Architect cortisol immunoassay","volume":"28","author":"Zha","year":"2022","journal-title":"Endocr Pract"},{"issue":"1","key":"2026012101525305800_dgaf424-B12","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1365-2265.1987.tb03638.x","article-title":"Re-evaluation of the clinical value of the 30\u2005min ACTH test in assessing the hypothalamic-pituitary-adrenocortical function","volume":"26","author":"Lindholm","year":"1987","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"2","key":"2026012101525305800_dgaf424-B13","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1046\/j.1365-2265.2000.01028.x","article-title":"Establishment of reference values for standard dose short Synacthen test (250 microgram), low dose short Synacthen test (1 microgram) and insulin tolerance test","volume":"53","author":"Gonz\u00e1lbez","year":"2000","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"1","key":"2026012101525305800_dgaf424-B14","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1365-2265.2012.04478.x","article-title":"Determining the utility of the 60\u2005min cortisol measurement in the short Synacthen test","volume":"79","author":"Chitale","year":"2013","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2026012101525305800_dgaf424-B15","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.clinbiochem.2018.02.010","article-title":"The effect of time of day testing and utility of 30 and 60 minute cortisol values in the 250 mcg ACTH stimulation test","volume":"54","author":"Munro","year":"2018","journal-title":"Clin Biochem"},{"issue":"1132","key":"2026012101525305800_dgaf424-B16","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1136\/postgradmedj-2019-136669","article-title":"Outcomes of the short Synacthen test: what is the role of the 60\u2005min sample in clinical practice?","volume":"96","author":"Dineen","year":"2020","journal-title":"Postgrad Med J"},{"issue":"6","key":"2026012101525305800_dgaf424-B17","first-page":"519","article-title":"Sixty-minute post-Synacthen serum cortisol level: a reliable and cost-effective screening test for excluding adrenal insufficiency","volume":"48","author":"Mansoor","year":"2007","journal-title":"Singapore Med J"},{"issue":"43","key":"2026012101525305800_dgaf424-B18","doi-asserted-by":"crossref","first-page":"e22621","DOI":"10.1097\/MD.0000000000022621","article-title":"Comparing the utility of 30- and 60-minute cortisol levels after the standard short Synacthen test","volume":"99","author":"Butt","year":"2020","journal-title":"Medicine (Baltimore)"},{"issue":"8","key":"2026012101525305800_dgaf424-B19","doi-asserted-by":"crossref","first-page":"e14417","DOI":"10.1111\/ijcp.14417","article-title":"What is the value of the 60-minute cortisol measurement in the short Synacthen test (SST)?","volume":"75","author":"Michaelidou","year":"2021","journal-title":"Int J Clin Pract"},{"key":"2026012101525305800_dgaf424-B20","doi-asserted-by":"crossref","first-page":"w13987","DOI":"10.4414\/smw.2014.13987","article-title":"Utility of 30 and 60 minute cortisol samples after high-dose synthetic ACTH-1-24 injection","volume":"144","author":"Zueger","year":"2014","journal-title":"Swiss Med Wkly"},{"issue":"1138","key":"2026012101525305800_dgaf424-B21","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1136\/postgradmedj-2019-137125","article-title":"Do we need 30min cortisol measurement in the short Synacthen test?","volume":"96","author":"Kumar","year":"2020","journal-title":"Postgrad Med J"},{"issue":"5","key":"2026012101525305800_dgaf424-B22","doi-asserted-by":"crossref","first-page":"e019273","DOI":"10.1136\/bmjopen-2017-019273","article-title":"Role of sampling times and serum cortisol cut-off concentrations on the assessment of adrenal function","volume":"8","author":"Ortiz-Flores","year":"2018","journal-title":"BMJ Open"},{"issue":"5","key":"2026012101525305800_dgaf424-B23","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1111\/cen.13559","article-title":"International survey on high- and low-dose Synacthen test","volume":"88","author":"Cross","year":"2018","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2026012101525305800_dgaf424-B24","author":"Chiang","year":"2021","journal-title":"Harmonisation of Endocrine Dynamic Testing\u2014Adult (HEDTA), Version 1.9"},{"key":"2026012101525305800_dgaf424-B25","volume-title":"A Language and Environment for Statistical Computing","author":"R Development Core Team","year":"2012"},{"key":"2026012101525305800_dgaf424-B26","doi-asserted-by":"crossref","unstructured":"Nolan JD, Brown SJ, Henley DE, Lim EM. 2025. Supplementary material for: Basal cortisol as a predictor of passing Short Synacthen Test and the utility of the 60-minute post-stimulation cortisol. Zenodo. doi:10.5281\/zenodo.15669366. Published June 15, 2025.","DOI":"10.1210\/clinem\/dgaf424"},{"issue":"2","key":"2026012101525305800_dgaf424-B27","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/cen.13232","article-title":"Baseline morning cortisol level as a predictor of pituitary-adrenal reserve: a comparison across three assays","volume":"86","author":"Sbardella","year":"2017","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"5","key":"2026012101525305800_dgaf424-B28","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1111\/cen.14071","article-title":"Validated criteria for the interpretation of a single measurement of serum cortisol in the investigation of suspected adrenal insufficiency","volume":"91","author":"Mackenzie","year":"2019","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"4","key":"2026012101525305800_dgaf424-B29","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1258\/acb.2010.010008","article-title":"Can a random serum cortisol reduce the need for short Synacthen tests in acute medical admissions?","volume":"47","author":"Kadiyala","year":"2010","journal-title":"Ann Clin Biochem"},{"issue":"8","key":"2026012101525305800_dgaf424-B30","doi-asserted-by":"crossref","first-page":"949","DOI":"10.4158\/EP171861.OR","article-title":"Diagnostic accuracy of basal cortisol level to predict adrenal insufficiency in cosyntropin testing: results from an observational cohort study with 804 patients","volume":"23","author":"Struja","year":"2017","journal-title":"Endocr Pract"},{"issue":"4","key":"2026012101525305800_dgaf424-B31","doi-asserted-by":"crossref","first-page":"E216","DOI":"10.25011\/cim.v36i4.19955","article-title":"The role of morning basal serum cortisol in assessment of hypothalamic pituitary-adrenal axis","volume":"36","author":"Yip","year":"2013","journal-title":"Clin Invest Med"},{"issue":"5","key":"2026012101525305800_dgaf424-B32","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1530\/EJE-15-0608","article-title":"Adrenal suppression in patients taking inhaled glucocorticoids is highly prevalent and management can be guided by morning cortisol","volume":"173","author":"Woods","year":"2015","journal-title":"Eur J Endocrinol"},{"issue":"1156","key":"2026012101525305800_dgaf424-B33","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1136\/postgradmedj-2020-138514","article-title":"Diagnostic performance of morning serum cortisol as an alternative to short Synacthen test for the assessment of adrenal reserve; a retrospective study","volume":"98","author":"Kumar","year":"2022","journal-title":"Postgrad Med J"},{"issue":"11","key":"2026012101525305800_dgaf424-B34","doi-asserted-by":"crossref","first-page":"e0225255","DOI":"10.1371\/journal.pone.0225255","article-title":"Diagnostic performance of basal cortisol level at 0900\u20131300h in adrenal insufficiency","volume":"14","author":"Manosroi","year":"2019","journal-title":"PLoS One"},{"issue":"4","key":"2026012101525305800_dgaf424-B35","doi-asserted-by":"crossref","first-page":"bvab022","DOI":"10.1210\/jendso\/bvab022","article-title":"New cutoffs for the biochemical diagnosis of adrenal insufficiency after ACTH stimulation using specific cortisol assays","volume":"5","author":"Javorsky","year":"2021","journal-title":"J Endocr Soc"},{"issue":"5","key":"2026012101525305800_dgaf424-B36","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/cen.13405","article-title":"A time-adjusted cortisol cut-off can reduce referral rate for Synacthen stimulation test whilst maintaining diagnostic performance","volume":"87","author":"Brown","year":"2017","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"12","key":"2026012101525305800_dgaf424-B37","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1159\/000514216","article-title":"Morning serum cortisol level predicts central adrenal insufficiency diagnosed by insulin tolerance test","volume":"111","author":"Gasco","year":"2021","journal-title":"Neuroendocrinology"},{"key":"2026012101525305800_dgaf424-B38","doi-asserted-by":"crossref","first-page":"11795514221093316","DOI":"10.1177\/11795514221093316","article-title":"Pre-test cortisol levels in predicting short Synacthen test outcome: a retrospective analysis","volume":"15","author":"Ravindran","year":"2022","journal-title":"Clin Med Insights Endocrinol Diabetes"},{"issue":"11","key":"2026012101525305800_dgaf424-B39","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1210\/jc.2008-0710","article-title":"Corticotropin tests for hypothalamic-pituitary-adrenal insufficiency: a meta-analysis","volume":"93","author":"Kazlauskaite","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2026012101525305800_dgaf424-B40","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/cen.14006","article-title":"Residual endogenous corticosteroid production in patients with adrenal insufficiency","volume":"91","author":"Vulto","year":"2019","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"1","key":"2026012101525305800_dgaf424-B41","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12902-016-0117-7","article-title":"How should we interrogate the hypothalamic-pituitary-adrenal axis in patients with suspected hypopituitarism?","volume":"16","author":"Garrahy","year":"2016","journal-title":"BMC Endocr Disord"},{"issue":"2","key":"2026012101525305800_dgaf424-B42","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/cen.13048","article-title":"Recovery of adrenal function after chronic secondary adrenal insufficiency in patients with hypopituitarism","volume":"85","author":"Munro","year":"2016","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"3","key":"2026012101525305800_dgaf424-B43","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s40618-022-01926-z","article-title":"Development and internal validation of a predictive score for the diagnosis of central adrenal insufficiency when morning cortisol is in the grey zone","volume":"46","author":"Bioletto","year":"2023","journal-title":"J Endocrinol Invest"},{"issue":"1","key":"2026012101525305800_dgaf424-B44","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00701-003-0174-3","article-title":"Impact of primary surgery on pituitary function in patients with non-functioning pituitary adenomas: a study on 721 patients","volume":"146","author":"Nomikos","year":"2004","journal-title":"Acta Neurochir (Wien)"},{"issue":"4","key":"2026012101525305800_dgaf424-B45","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1210\/jc.2011-2227","article-title":"Urban FK 3rd. Estimation of maximal cortisol secretion rate in healthy humans","volume":"97","author":"Dorin","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2026012101525305800_dgaf424-B46","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1055\/s-0029-1202275","article-title":"The low-dose (1 microg) cosyntropin test for primary adrenocortical insufficiency: defining the normal cortisol response and report on first patients with Addison disease confirmed with LDT","volume":"118","author":"Pura","year":"2010","journal-title":"Exp Clin Endocrinol Diabetes"},{"issue":"2","key":"2026012101525305800_dgaf424-B47","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s11102-010-0270-3","article-title":"Comparison of low and standard dose ACTH and glucagon stimulation tests in the evaluation of hypothamo-pituitary-adrenal axis in healthy adults","volume":"14","author":"Karaca","year":"2011","journal-title":"Pituitary"},{"issue":"2","key":"2026012101525305800_dgaf424-B48","doi-asserted-by":"crossref","first-page":"EVIDoa2200182","DOI":"10.1056\/EVIDoa2200182","article-title":"Home waking salivary cortisone to screen for adrenal insufficiency","volume":"2","author":"Debono","year":"2023","journal-title":"NEJM Evid"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgaf424\/63833984\/dgaf424.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/111\/2\/e398\/63833984\/dgaf424.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/111\/2\/e398\/63833984\/dgaf424.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T06:53:23Z","timestamp":1768978403000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/111\/2\/e398\/8211069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,23]]},"references-count":48,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,7,23]]},"published-print":{"date-parts":[[2026,1,21]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgaf424","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,2]]},"published":{"date-parts":[[2025,7,23]]}}}