{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:14:28Z","timestamp":1771546468157,"version":"3.50.1"},"reference-count":52,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2025,8,16]],"date-time":"2025-08-16T00:00:00Z","timestamp":1755302400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100002661","name":"Fund for Scientific Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011878","name":"Flanders","doi-asserted-by":"publisher","award":["G.0332.02"],"award-info":[{"award-number":["G.0332.02"]}],"id":[{"id":"10.13039\/501100011878","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011878","name":"Flanders","doi-asserted-by":"publisher","award":["G.0662.07"],"award-info":[{"award-number":["G.0662.07"]}],"id":[{"id":"10.13039\/501100011878","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To study bone turnover markers (BTM) and sex steroids in relation to trabecular bone score (TBS) in men.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Longitudinal, population-based study in 465 healthy men, aged 25 to 45 years at baseline. Lumbar spine TBS was calculated with TBS iNsight\u00ae version 4 (v19.4.1, core module, Medimaps, Pessac, France), which adjusts for soft tissue thickness correction via dual-energy X-ray absorptiometry measurements. SHBG, C-terminal telopeptide, and procollagen type 1 N-terminal propeptide were measured using immunoassays. Total testosterone (T) and estradiol (E2) were determined by liquid chromatography-tandem mass spectrometry and free T and free E2 calculated. Statistical analyses were conducted via linear mixed-effects modeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At baseline, TBS was positively associated with free T (P = .01), free E2, and total E2 (both P &amp;lt; .001) but not with total T nor with BTM. Over a follow-up of 12.5 years, TBS declined by 1.43% (P &amp;lt; .001). Higher baseline body mass index and trunk fat were predictive of greater decreases in TBS (P = .01 and P = .02). Neither baseline levels of sex steroids and BTM nor changes therein were associated with changes in TBS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TBS already decreases in young and middle-aged healthy men, corroborating earlier studies showing early decrease of trabecular bone volume and changes in trabecular microarchitecture. Although we identified some potentially contributing determinants, the underlying mechanisms of changes in TBS and trabecular bone in young men are yet to be fully elucidated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf461","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T11:52:54Z","timestamp":1755172374000},"page":"e908-e916","source":"Crossref","is-referenced-by-count":0,"title":["Changes in Trabecular Bone Score and Their Determinants in Young and Middle-aged Men: A Longitudinal Observational Study"],"prefix":"10.1210","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7682-2189","authenticated-orcid":false,"given":"Ya\u00ebl","family":"Sertons","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Ghent University Hospital & Department of Internal Medicine and Pediatrics, Ghent University , Ghent 9000 ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2550-290X","authenticated-orcid":false,"given":"Thiberiu","family":"Banica","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Ghent University Hospital & Department of Internal Medicine and Pediatrics, Ghent University , Ghent 9000 ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Goemaere","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Ghent University Hospital & Department of Internal Medicine and Pediatrics, Ghent University , Ghent 9000 ,","place":["Belgium"]},{"name":"Unit for Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital , Ghent 9000 ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Fiers","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Ghent University Hospital , Ghent 9000 ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Marc","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Ghent University Hospital & Department of Internal Medicine and Pediatrics, Ghent University , Ghent 9000 ,","place":["Belgium"]},{"name":"Unit for Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital , Ghent 9000 ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1584-4965","authenticated-orcid":false,"given":"Bruno","family":"Lapauw","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Ghent University Hospital & Department of Internal Medicine and Pediatrics, Ghent University , Ghent 9000 ,","place":["Belgium"]},{"name":"Unit for Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital , Ghent 9000 ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2451-9419","authenticated-orcid":false,"given":"Charlotte","family":"Verroken","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Ghent University Hospital & Department of Internal Medicine and Pediatrics, Ghent University , Ghent 9000 ,","place":["Belgium"]},{"name":"Unit for Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital , Ghent 9000 ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2025,8,16]]},"reference":[{"issue":"5","key":"2026021918520098800_dgaf461-B1","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.beem.2018.05.007","article-title":"Update on osteoporosis in men","volume":"32","author":"Adler","year":"2018","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"3","key":"2026021918520098800_dgaf461-B2","doi-asserted-by":"crossref","first-page":"R75","DOI":"10.1530\/EJE-20-0034","article-title":"Management of endocrine disease: male osteoporosis: diagnosis and management\u2014should the treatment and the target be the same as for female osteoporosis?","volume":"183","author":"Porcelli","year":"2020","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"2026021918520098800_dgaf461-B3","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00198-015-3222-y","article-title":"Trabecular bone score in type 1 diabetes\u2014a cross-sectional study","volume":"27","author":"Neumann","year":"2016","journal-title":"Osteoporos Int"},{"issue":"2","key":"2026021918520098800_dgaf461-B4","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4103\/1008-682X.122356","article-title":"Androgens and estrogens in skeletal sexual dimorphism","volume":"16","author":"Laurent","year":"2014","journal-title":"Asian J Androl"},{"issue":"5","key":"2026021918520098800_dgaf461-B5","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1002\/jbmr.2734","article-title":"A meta-analysis of trabecular bone score in fracture risk prediction and its relationship to FRAX","volume":"31","author":"McCloskey","year":"2016","journal-title":"J Bone Miner Res"},{"key":"2026021918520098800_dgaf461-B6","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.bone.2015.05.016","article-title":"Trabecular bone score (TBS) as a new complementary approach for osteoporosis evaluation in clinical practice","volume":"78","author":"Harvey","year":"2015","journal-title":"Bone"},{"key":"2026021918520098800_dgaf461-B7","first-page":"S1","article-title":"Risk-equivalent\u201d t-score adjustment using lumbar spine trabecular bone score (TBS): the Manitoba BMD registry","volume":"32","author":"Leslie","year":"2017","journal-title":"J Bone Miner Res"},{"issue":"4","key":"2026021918520098800_dgaf461-B8","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.bone.2007.11.018","article-title":"Correlations between grey-level variations in 2D projection images (TBS) and 3D microarchitecture: applications in the study of human trabecular bone microarchitecture","volume":"42","author":"Pothuaud","year":"2008","journal-title":"Bone"},{"issue":"1","key":"2026021918520098800_dgaf461-B9","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00198-015-3211-1","article-title":"Bone status in glucocorticoid-treated men and women","volume":"27","author":"Leib","year":"2016","journal-title":"Osteoporos Int"},{"issue":"1","key":"2026021918520098800_dgaf461-B10","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jocd.2013.05.001","article-title":"Spine trabecular bone score subsequent to bone mineral density improves fracture discrimination in women","volume":"17","author":"Krueger","year":"2014","journal-title":"J Clin Densitom"},{"issue":"1","key":"2026021918520098800_dgaf461-B11","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jocd.2013.03.003","article-title":"Effects of Exemestane and Tamoxifen treatment on bone texture analysis assessed by TBS in comparison with bone mineral density assessed by DXA in women with breast cancer","volume":"17","author":"Kalder","year":"2014","journal-title":"J Clin Densitom"},{"issue":"11","key":"2026021918520098800_dgaf461-B12","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1002\/jbmr.499","article-title":"Bone microarchitecture assessed by TBS predicts osteoporotic fractures independent of bone density: the Manitoba study","volume":"26","author":"Hans","year":"2011","journal-title":"J Bone Miner Res"},{"issue":"5","key":"2026021918520098800_dgaf461-B13","doi-asserted-by":"crossref","first-page":"e13347","DOI":"10.1111\/ijcp.13347","article-title":"Assessment of bone quality with trabecular bone score in type 2 diabetes mellitus: a study from the FRISBEE cohort","volume":"73","author":"Baleanu","year":"2019","journal-title":"Int J Clin Pract"},{"issue":"6","key":"2026021918520098800_dgaf461-B14","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1007\/s00198-018-4468-y","article-title":"The trabecular bone score is associated with bone mineral density, markers of bone turnover and prevalent fracture in patients with end stage kidney disease","volume":"29","author":"Aleksova","year":"2018","journal-title":"Osteoporos Int"},{"issue":"3","key":"2026021918520098800_dgaf461-B15","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.bone.2006.10.023","article-title":"Geographic and other determinants of BMD change in European men and women at the hip and spine. A population-based study from the Network in Europe for Male Osteoporosis (NEMO)","volume":"40","author":"Kaptoge","year":"2007","journal-title":"Bone"},{"issue":"12","key":"2026021918520098800_dgaf461-B16","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1007\/s00198-005-2000-7","article-title":"Determinants of bone mineral density in Chinese men","volume":"16","author":"Cheung","year":"2005","journal-title":"Osteoporos Int"},{"issue":"11","key":"2026021918520098800_dgaf461-B17","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1359\/jbmr.2001.16.11.2142","article-title":"Determinants of bone mineral density in older men and women: body composition as mediator","volume":"16","author":"Pluijm","year":"2001","journal-title":"J Bone Miner Res"},{"issue":"11","key":"2026021918520098800_dgaf461-B18","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1007\/s00198-013-2384-8","article-title":"Generation and validation of a normative, age-specific reference curve for lumbar spine trabecular bone score (TBS) in French women","volume":"24","author":"Dufour","year":"2013","journal-title":"Osteoporos Int"},{"key":"2026021918520098800_dgaf461-B19","first-page":"232","article-title":"Determinants of vertebral fracture status and trabecular bone score in women with fragility fractures: a cross-sectional sub-study of NoFRACT","volume":"34","author":"Borgen","year":"2019","journal-title":"J Bone Miner Res"},{"issue":"2","key":"2026021918520098800_dgaf461-B20","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/s12020-016-0857-1","article-title":"Assessment of trabecular bone score (TBS) in overweight\/obese men: effect of metabolic and anthropometric factors","volume":"54","author":"Romagnoli","year":"2016","journal-title":"Endocrine"},{"issue":"7","key":"2026021918520098800_dgaf461-B21","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1002\/jbmr.3130","article-title":"Association of trabecular bone score (TBS) with incident clinical and radiographic vertebral fractures adjusted for lumbar spine BMD in older men: a prospective cohort study","volume":"32","author":"Schousboe","year":"2017","journal-title":"J Bone Miner Res"},{"issue":"6","key":"2026021918520098800_dgaf461-B22","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1007\/s00198-014-2685-6","article-title":"TBS result is not affected by lumbar spine osteoarthritis","volume":"25","author":"Kolta","year":"2014","journal-title":"Osteoporos Int"},{"issue":"2","key":"2026021918520098800_dgaf461-B23","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jocd.2016.11.003","article-title":"Densitometer-specific differences in the correlation between body mass index and lumbar spine trabecular bone score","volume":"20","author":"Mazzetti","year":"2017","journal-title":"J Clin Densitom"},{"issue":"3","key":"2026021918520098800_dgaf461-B24","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00198-017-4314-7","article-title":"Independent association of bone mineral density and trabecular bone score to vertebral fracture in male subjects with chronic obstructive pulmonary disease","volume":"29","author":"Watanabe","year":"2018","journal-title":"Osteoporos Int"},{"key":"2026021918520098800_dgaf461-B25","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.bone.2015.06.007","article-title":"TBS reflects trabecular microarchitecture in premenopausal women and men with idiopathic osteoporosis and low-traumatic fractures","volume":"79","author":"Muschitz","year":"2015","journal-title":"Bone"},{"issue":"4","key":"2026021918520098800_dgaf461-B26","doi-asserted-by":"crossref","first-page":"e1074","DOI":"10.1210\/clinem\/dgaa915","article-title":"Early decline of androgen levels in healthy adult men: an effect of aging per se? A prospective cohort study","volume":"106","author":"Banica","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"2026021918520098800_dgaf461-B27","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1210\/jcem.86.8.7736","article-title":"Relationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly men","volume":"86","author":"Khosla","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"2026021918520098800_dgaf461-B28","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1210\/jcem.84.10.6079","article-title":"A critical evaluation of simple methods for the estimation of free testosterone in serum","volume":"84","author":"Vermeulen","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2026021918520098800_dgaf461-B29","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1093\/ajcn\/36.5.936","article-title":"A short questionnaire for the measurement of habitual physical activity in epidemiological studies","volume":"36","author":"Baecke","year":"1982","journal-title":"Am J Clin Nutr"},{"key":"2026021918520098800_dgaf461-B30","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jchromb.2012.02.034","article-title":"Development of a highly sensitive method for the quantification of estrone and estradiol in serum by liquid chromatography tandem mass spectrometry without derivatization","volume":"893-894","author":"Fiers","year":"2012","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"2026021918520098800_dgaf461-B31","author":"TBS Report: Guidance Notes"},{"key":"2026021918520098800_dgaf461-B32","unstructured":"Sertons Y, Banica T, Lapauw B, Kaufman J-M, Goemaere S, Verroken C. 2025. Supplementary material for peer review_changes in TBS.pdf. doi:10.6084\/m9.figshare.29430362.v1."},{"issue":"1","key":"2026021918520098800_dgaf461-B33","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s11657-020-00731-6","article-title":"Longitudinal changes in bone mineral density and trabecular bone score in Korean adults: a community-based prospective study","volume":"15","author":"Park","year":"2020","journal-title":"Arch Osteoporos"},{"issue":"1","key":"2026021918520098800_dgaf461-B34","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1359\/JBMR.050916","article-title":"Effects of sex and age on bone microstructure at the ultradistal radius: a population-based noninvasive in vivo assessment","volume":"21","author":"Khosla","year":"2006","journal-title":"J Bone Miner Res"},{"issue":"2","key":"2026021918520098800_dgaf461-B35","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1359\/jbmr.071020","article-title":"A population-based assessment of rates of bone loss at multiple skeletal sites: evidence for substantial trabecular bone loss in young adult women and men","volume":"23","author":"Riggs","year":"2008","journal-title":"J Bone Miner Res"},{"issue":"2","key":"2026021918520098800_dgaf461-B36","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/jbmr.3303","article-title":"Bone turnover in young adult men: cross-sectional determinants and associations with prospectively assessed bone loss","volume":"33","author":"Verroken","year":"2018","journal-title":"J Bone Miner Res"},{"issue":"9","key":"2026021918520098800_dgaf461-B37","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1359\/jbmr.2001.16.9.1642","article-title":"Cross-sectional evaluation of bone metabolism in men","volume":"16","author":"Szulc","year":"2001","journal-title":"J Bone Miner Res"},{"issue":"11","key":"2026021918520098800_dgaf461-B38","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1002\/jbmr.124","article-title":"Association between bone turnover rate and bone microarchitecture in men: the STRAMBO study","volume":"25","author":"Chaitou","year":"2010","journal-title":"J Bone Miner Res"},{"issue":"1","key":"2026021918520098800_dgaf461-B39","first-page":"7","article-title":"Clinical use of bone markers: a challenge to variability","volume":"5","author":"Filella","year":"2024","journal-title":"Adv Lab Med"},{"issue":"6","key":"2026021918520098800_dgaf461-B40","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1210\/er.2014-1024","article-title":"Sex steroid actions in male bone","volume":"35","author":"Vanderschueren","year":"2014","journal-title":"Endocr Rev"},{"issue":"5","key":"2026021918520098800_dgaf461-B41","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/jbmr.4543","article-title":"Modest changes in sex hormones during early and middle adulthood affect bone mass and size in healthy men: a prospective cohort study","volume":"37","author":"Banica","year":"2022","journal-title":"J Bone Miner Res"},{"key":"2026021918520098800_dgaf461-B42","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.bone.2016.01.009","article-title":"Sex hormones, sex hormone binding globulin, and vertebral fractures in older men","volume":"84","author":"Cawthon","year":"2016","journal-title":"Bone"},{"issue":"7","key":"2026021918520098800_dgaf461-B43","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1359\/jbmr.2000.15.7.1405","article-title":"Hormonal and biochemical parameters and osteoporotic fractures in elderly men","volume":"15","author":"Center","year":"2000","journal-title":"J Bone Miner Res"},{"issue":"4","key":"2026021918520098800_dgaf461-B44","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1210\/jc.2009-2189","article-title":"Sex hormone-binding globulin as an independent determinant of cortical bone status in men at the age of peak bone mass","volume":"95","author":"Vanbillemont","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2026021918520098800_dgaf461-B45","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00198-017-4273-z","article-title":"Predictors of change of trabecular bone score (TBS) in older men: results from the Osteoporotic Fractures in Men (MrOS) Study","volume":"29","author":"Schousboe","year":"2018","journal-title":"Osteoporos Int"},{"issue":"1","key":"2026021918520098800_dgaf461-B46","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12891-016-0886-1","article-title":"Simulated increased soft tissue thickness artefactually decreases trabecular bone score: a phantom study","volume":"17","author":"Amnuaywattakorn","year":"2016","journal-title":"BMC Musculoskelet Disord"},{"issue":"3","key":"2026021918520098800_dgaf461-B47","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s00198-018-4405-0","article-title":"Risk-equivalent T-score adjustment for using lumbar spine trabecular bone score (TBS): the Manitoba BMD registry","volume":"29","author":"Leslie","year":"2018","journal-title":"Osteoporos Int"},{"issue":"4","key":"2026021918520098800_dgaf461-B48","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/jbmr.4774","article-title":"Contributions of clinical and technical factors to longitudinal change in trabecular bone score and bone density: a registry-based individual-level analysis","volume":"38","author":"Leslie","year":"2023","journal-title":"J Bone Miner Res"},{"issue":"7","key":"2026021918520098800_dgaf461-B49","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1093\/jbmr\/zjae073","article-title":"Effect of abdominal tissue thickness on trabecular bone score and fracture risk in adults with diabetes: the Manitoba BMD registry","volume":"39","author":"Leslie","year":"2024","journal-title":"J Bone Miner Res"},{"issue":"3","key":"2026021918520098800_dgaf461-B50","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/obr.12244","article-title":"Complex association between body weight and fracture risk in postmenopausal women","volume":"16","author":"Mpalaris","year":"2015","journal-title":"Obes Rev"},{"issue":"4","key":"2026021918520098800_dgaf461-B51","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s00198-023-06991-5","article-title":"Obesity, diabetes and risk of bone fragility: how BMAT behavior is affected by metabolic disturbances and its influence on bone health","volume":"35","author":"Guimar\u00e3es","year":"2024","journal-title":"Osteoporos Int"},{"issue":"4","key":"2026021918520098800_dgaf461-B52","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s00198-025-07421-4","article-title":"Advancing trabecular bone score (TBS): clinical performance of TBS version 4.0 with direct correction for soft tissue thickness-the osteolaus study","volume":"36","author":"Gatineau","year":"2025","journal-title":"Osteoporos Int"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgaf461\/64067941\/dgaf461.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/111\/3\/e908\/64067941\/dgaf461.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/111\/3\/e908\/64067941\/dgaf461.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T23:52:17Z","timestamp":1771545137000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/111\/3\/e908\/8236486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,16]]},"references-count":52,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,8,16]]},"published-print":{"date-parts":[[2026,2,20]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgaf461","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,3]]},"published":{"date-parts":[[2025,8,16]]}}}