{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:45:49Z","timestamp":1793727949302,"version":"4.6.1"},"reference-count":61,"publisher":"The Endocrine Society","issue":"12","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Cervical lymph node metastases are common in papillary thyroid carcinoma (PTC), causing recurrence and poor regional control, highlighting the need for accurate diagnostics. Although fine-needle aspiration with thyroglobulin washout (FNA-Tg) shows promise, its diagnostic performance and association with serum biomarkers across settings remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the diagnostic performance of FNA-Tg for cervical lymph node metastases in PTC and its correlation with serum thyroglobin (s-Tg) and s-Tg antibody (s-Tg-Ab) levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>PubMed, Embase, Web of Science, Scopus, Cochrane Library, and Ovid Medline were searched for relevant studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Selection<\/jats:title>\n                    <jats:p>Studies enrolling PTC patients with cervical lymphadenopathy who underwent FNA-Tg pre- or postthyroidectomy were included. Studies involving non-PTC populations or lacking sufficient data for 2 \u00d7 2 diagnostic table construction were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Extraction<\/jats:title>\n                    <jats:p>Data were independently extracted by 3 researchers, and study quality was assessed by the Quality Assessment of Diagnostic Accuracy Studies-2 tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Synthesis<\/jats:title>\n                    <jats:p>FNA-Tg showed pooled sensitivity of 0.94 [95% confidence interval (CI), 0.91-0.96], specificity of 0.92 (95% CI: 0.88-0.94), and diagnostic odds ratio (DOR) of 174.20 (95% CI: 87.05-348.61), with an area under curve (AUC) of 0.98 (95% CI: 0.96-0.99). Postthyroidectomy, sensitivity increased to 0.96 (95% CI: 0.94-0.98), specificity to 0.93 (95% CI: 0.86-0.96), and DOR to 305.87 (95% CI: 127.99-730.93), with an AUC of 0.98 (95% CI: 0.97-0.99). In the group without thyroid gland present, sensitivity was 0.96 (95% CI: 0.93-0.97), specificity 0.93 (95% CI: 0.87-0.97), and DOR 300.27 (95% CI: 118.47-761.05), with an AUC of 0.98 (95% CI: 0.97-0.99). Likelihood ratio scattergrams and Fagan plots supported its discriminatory ability. FNA-Tg correlated weakly with s-Tg but not with s-Tg-Ab.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>FNA-Tg showed high diagnostic accuracy, especially after thyroidectomy, with minimal s-Tg-Ab interference, supporting its role in PTC surveillance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf467","type":"journal-article","created":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T11:21:27Z","timestamp":1755429687000},"page":"3569-3587","source":"Crossref","is-referenced-by-count":12,"title":["Diagnostic Efficiency of Thyroglobulin in Lymph Node Fine-needle Aspiration Washout: A Systematic Review and Meta-analysis"],"prefix":"10.1210","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7611-3098","authenticated-orcid":false,"given":"Chen-Yeh","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, 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