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Hertz og hustru Inger Hertz\u2019 Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006088","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006308","name":"Helga og Peter Kornings Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006308","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Henry og Astrid M\u00f8llers Fond"},{"DOI":"10.13039\/501100010371","name":"Raimond og Dagmar Ringg\u00e5rd-Bohns Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010371","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Alternate-day fasting (ADF) is a dietary regimen with prolonged fasting periods associated with metabolic and cardiovascular benefits. It remains unclear if ADF improves cardiac function and metabolism to explain these benefits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate the effects of a 3-week ADF intervention on myocardial efficiency, perfusion, and substrate metabolism in overweight\/obese individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixteen participants with overweight (body mass index: 32 \u00b1 1.9\u2005kg\/m2) completed this randomized crossover study comparing ADF with a standard diet. Dynamic cardiac positron emission tomography scans were performed using 5 tracers: [15O]water to assess myocardial blood flow and flow reserve (MFR), [11C]acetate to measure myocardial oxygen consumption (MVO2) and myocardial external efficiency (MEE), and [11C]\u03b2-hydroxybutyrate, [11C]palmitate, and [18F]fluorodeoxyglucose to assess metabolism of \u03b2-hydroxybutyrate (OHB), free fatty acid (FFA), and glucose, respectively. Blood samples were analyzed for OHB, FFA, glucose, lactate, and insulin. Blood pressure, heart rate, cardiac output, and left ventricular mass, ejection fraction, and volumes were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ADF increased circulating ketones on fasting days (peak: 0.67 \u00b1 0.09\u2005mmol\/L), which remained elevated on eating days (0.20 \u00b1 0.03\u2005mmol\/L). However, myocardial substrate metabolism remained unaltered following ADF. Blood pressure and cardiac output significantly decreased after ADF (systolic\/diastolic: 13\/9 mmHg and 0.5 L\/min, respectively; P &amp;lt; .001). MVO2 decreased by 10% (P = .01) and total left ventricular energy use by 19% (P &amp;lt; .01). Resting myocardial perfusion decreased by 9% (P &amp;lt; .05), and MFR increased by 34% (P &amp;lt; .01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A 3-week ADF regimen reduced blood pressure and MVO2, and improved MFR, suggesting ADF may provide a nonpharmacological strategy to improve cardiovascular health in individuals with overweight.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf484","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T11:32:47Z","timestamp":1756207967000},"page":"744-756","source":"Crossref","is-referenced-by-count":4,"title":["Three-week Alternate-day Fasting Improves Myocardial Flow Reserve and Reduces Oxygen Use in Overweight Individuals"],"prefix":"10.1210","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1215-2207","authenticated-orcid":false,"given":"Mette Louise Gram","family":"Kj\u00e6rulff","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine, Aarhus University , 8200 Aarhus N ,","place":["Denmark"]},{"name":"Steno Diabetes Center Aarhus, Aarhus University Hospital , 8200 Aarhus N ,","place":["Denmark"]},{"name":"Department of Nuclear Medicine and PET Centre, Aarhus University Hospital , 8200 Aarhus N ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5772-4494","authenticated-orcid":false,"given":"Thien Vinh","family":"Luong","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Aarhus University , 8200 Aarhus N ,","place":["Denmark"]},{"name":"Steno Diabetes Center Aarhus, Aarhus University Hospital , 8200 Aarhus N ,","place":["Denmark"]},{"name":"Department of Nuclear Medicine and PET Centre, Aarhus University Hospital , 8200 Aarhus N 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