{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T17:52:08Z","timestamp":1776880328276,"version":"3.51.2"},"reference-count":61,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100009259","name":"Institute for Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009259","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008013","name":"University of Texas Medical Branch","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019337","name":"Clinical and Translational Science","doi-asserted-by":"publisher","award":["UL1 TR001439"],"award-info":[{"award-number":["UL1 TR001439"]}],"id":[{"id":"10.13039\/100019337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Bariatric surgery (BS) effectively reduces obesity-related risks, but its outcomes in patients with preexisting hypothyroidism are unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the impact of preexisting hypothyroidism on adverse health outcomes following BS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective cohort study utilizing the TriNetX Global Collaborative Network database, patients with obesity who underwent BS or not, with and without hypothyroidism, were propensity score-matched. Short-term outcomes comprised mortality, readmission, ICU admission, and surgical and systemic complications. Long-term outcomes included mortality, major adverse events, bone health, and metabolic, renal, and neurological outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were 5700 patients in each cohort (46.7 \u00b1 12 years, 88% female). In the short term, patients with hypothyroidism exhibited higher risks of readmission (risk ratio [RR]:\u202f1.25; CI:\u202f1.14-1.36), incisional hernia (RR:\u202f1.56; CI:\u202f1.12-2.18), and biliary diseases (RR:\u202f1.39; CI:\u202f1.05-1.86). In the long term, patients with hypothyroidism had higher risks of incident cerebrovascular events (hazard ratio [HR]:\u202f1.25; CI:\u202f1.00-1.55), diabetes (HR:\u202f1.39; CI:\u202f1.12-1.74), and dyslipidemia (HR:\u202f1.20; CI:\u202f1.02-1.42). There were also higher risks of fall (HR:\u202f1.20; CI:\u202f1.02-1.40), osteoporosis (HR:\u202f1.30; CI:\u202f1.07-1.58), polyneuropathy (HR:\u202f1.34; CI:\u202f1.08-1.66), hypoglycemia (HR:\u202f1.51; CI:\u202f1.23-1.87), as well as iron (HR:\u202f1.17; CI:\u202f1.04-1.31) and vitamin B (HR:\u202f1.34; CI:\u202f1.20-1.49) deficiencies. Hypothyroidism-associated risks of poor outcomes were higher in patients who underwent gastric bypass. Compared to the nonsurgical care, patients with hypothyroidism who underwent BS showed a lower risk of obesity-related outcomes but a higher risk of iron and vitamin B deficiencies, osteoporosis, and hypoglycemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Preexisting hypothyroidism in bariatric patients increases the risks of adverse outcomes. However, the risk of obesity-related outcomes is decreased in this population when compared to nonsurgical care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf519","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T11:43:39Z","timestamp":1758023019000},"page":"e766-e777","source":"Crossref","is-referenced-by-count":3,"title":["Adverse Outcomes in Patients With Hypothyroidism Undergoing Bariatric Surgery: A Retrospective Study Using TriNetX"],"prefix":"10.1210","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2787-6841","authenticated-orcid":false,"given":"Vandrize","family":"Meneghini","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Texas Medical Branch , Galveston, TX 77555 ,","place":["USA"]},{"name":"Center for Clinical and Epidemiological Research, Universidade de S\u00e3o Paulo , S\u00e3o Paulo, SP 05508-000 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9713-2584","authenticated-orcid":false,"given":"Fabyan Esberard de Lima","family":"Beltr\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Texas Medical Branch , Galveston, TX 77555 ,","place":["USA"]},{"name":"Department of Internal Medicine, Lauro Wanderley University Hospital, Federal University of Para\u00edba , Jo\u00e3o Pessoa, PB 58050-585 ,","place":["Brazil"]},{"name":"Department of Internal Medicine, University Center of Jo\u00e3o Pessoa (UNIPE) , Jo\u00e3o Pessoa, PB 58053-000 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4609-2767","authenticated-orcid":false,"given":"George","family":"Golovko","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Texas Medical Branch , Galveston, TX 77555 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0242-6091","authenticated-orcid":false,"given":"Riley K","family":"Watson","sequence":"additional","affiliation":[{"name":"Institute for Translational Sciences, University of Texas Medical Branch , Galveston, TX 77555 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2096-7468","authenticated-orcid":false,"given":"Sarah","family":"Samreen","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Texas Medical Branch , Galveston, TX 77555 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0328-1752","authenticated-orcid":false,"given":"Matthew D","family":"Ettleson","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Diabetes, and Metabolism, University of Chicago , Chicago, IL 60637 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6723-5678","authenticated-orcid":false,"given":"Isabela M","family":"Bense\u00f1or","sequence":"additional","affiliation":[{"name":"Center for Clinical and Epidemiological Research, Universidade de S\u00e3o Paulo , S\u00e3o Paulo, SP 05508-000 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7737-6813","authenticated-orcid":false,"given":"Antonio C","family":"Bianco","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Texas Medical Branch , Galveston, TX 77555 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2025,9,16]]},"reference":[{"issue":"1","key":"2026021918530148500_dgaf519-B1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cmet.2021.12.012","article-title":"Why does obesity cause diabetes?","volume":"34","author":"Klein","year":"2022","journal-title":"Cell Metab"},{"issue":"17","key":"2026021918530148500_dgaf519-B2","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1093\/eurjpc\/zwac187","article-title":"Obesity and cardiovascular disease: mechanistic insights and management strategies. 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