{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T16:34:30Z","timestamp":1787157270023,"version":"build-2736575974"},"reference-count":51,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Ohio State University Comprehensive Center","award":["P30 CA016058"],"award-info":[{"award-number":["P30 CA016058"]}]},{"name":"Genomics Shared Resource","award":["P30 CA016058"],"award-info":[{"award-number":["P30 CA016058"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Rates of pediatric differentiated thyroid cancer (DTC) in the United States have been increasing while studies on this population remain limited by inconsistent age cutoffs, short follow-up periods, or relative lack of clinical data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This work aimed to report long-term outcomes in patients diagnosed with DTC at age 20 years and younger.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study was conducted of patients diagnosed with DTC at age 20 years or younger with long-term follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 155 patients were included with a median age at diagnosis of 17 years (9-20 years). The frequency of distant metastasis and larger tumor size were inversely related to age at diagnosis (overall stage P = .045; T-stage (size of the primary tumor \u00b1 invasion); P = .001). The median duration of follow-up was 16 years (1-63 years) and at last follow-up, 52.3% of patients had excellent response and disease specific mortality was 0%. There was no difference in response to therapy based on histologic subtype or birth sex; however, younger age at diagnosis was associated with worse response (P = .046). Patients with more than 50 years of follow-up (n = 9) had a median of 36 years of stability, with progression occurring in 6 out of 9 (67%) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients diagnosed with DTC as children or young adults have outstanding long-term survivorship, but may experience disease progression later in life, suggesting that long-term follow-up might be appropriate for this population. Younger age at diagnosis was identified as a risk factor for distant metastases and poorer response to therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf522","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T12:03:19Z","timestamp":1758110599000},"page":"e715-e724","source":"Crossref","is-referenced-by-count":2,"title":["Long-Term Outcomes of Patients Diagnosed With Differentiated Thyroid Cancer in Childhood and Young Adulthood"],"prefix":"10.1210","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0600-3918","authenticated-orcid":false,"given":"Anisley","family":"Valenciaga","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, The Ohio State University College of Medicine and Arthur G. 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